Alteration of the Expression and Functional Activities of Myosin II Isoforms in Enlarged Hyperplastic Prostates
Xiao Wang,
Weixiang He,
Hui Chen
et al.
Abstract:Introduction: Benign prostatic hyperplasia (BPH) is a common pathologic process in aging men, and the contraction of the prostatic smooth muscles (SMs) in the stroma plays a vital role in this pathogenesis, leading to lower urinary tract symptoms (LUTSs). The isoforms of both the SM myosin (SMM) and non-muscle myosin (NMM) are associated with the contraction type of the prostatic SMs, but the mechanism has not been fully elucidated. Methods: We collected prostate tissues from 30 BPH patients receiving surgical… Show more
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