Alteration of prothrombin time in Plasmodium falciparum and Plasmodium vivax infections with different levels of severity: a systematic review and meta-analysis

Sukati, Suriyan; Wannatung, Tirawat; Duangchan, Thitinat; Kotepui, Kwuntida Uthaisar; Masangkay, Frederick Ramirez; Tseng, Ching-Ping; Kotepui, Manas

doi:10.1038/s41598-024-60170-y

Cited by 1 publication

(1 citation statement)

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“…Recent research concluded that thrombocytopenia is an excellent diagnostic marker of malaria, with 86.3% specificity and 79.5% sensitivity [ 21 ]. The effect of malaria severity on coagulation parameters is well documented [ 22 , 23 ]. A high parasitaemia load leads to anomalies in the synthesising and secretion of coagulation factors and their inhibitors and hepatic microcirculation blockage.…”

Section: Discussionmentioning

confidence: 99%

Haematological Profile in Patients With Acute Falciparum Malaria: A Hospital-Based Study

Roy,

Saha,

Ahmed

et al. 2024

Cureus

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Introduction Malaria is the most common parasitic disease affecting humans. Haematological alterations in malaria are expected, and these changes play a significant role in fatal complications. The present study aims to assess the clinical and haematological profile in patients with acute falciparum malaria and the significance of various haematological and coagulation alterations with the clinical severity of malaria. Methods The prospective cross-sectional study included 68 acute falciparum malaria cases. Thick and thin blood film microscopy and a rapid diagnostic kit were used to diagnose malaria. The cases were subjected to various haematological and biochemical investigations. Bone marrow aspiration samples were also collected. Using appropriate statistical methods, the findings were compared between severe and uncomplicated malaria cases. A p-value below 0.05 was considered significant. Results The participants’ ages ranged from 14 to 78. Most participants (n = 51, 75%) were male and belonged to the lower income group (33, 48.5%). Significant variations in mean parasite count between severe and uncomplicated malaria cases (p-value < 0.01) were observed. The severe and uncomplicated groups showed significant differences in haemoglobin (gm/dL), haematocrit, red blood cell count, reticulocyte, serum iron, and ESR levels (p-value < 0.05). The severe malaria group had considerably reduced mean platelet counts (p-value < 0.01). Only five instances (7.3%) had an appropriate erythropoietic response after day 28. Erythroid hyperplasia with dyserythropoietic alterations was most common in patients with severe anaemia and low-grade parasitaemia. Conclusion Acute falciparum malaria is often associated with haematological alterations. Anaemia and thrombocytopenia were the most expected alterations associated with disease prognosis and mortality.

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Section: Discussionmentioning

confidence: 99%