Alteration of prognostic efficacy of albumin‐bilirubin grade and Child‐Pugh score according to liver fibrosis in hepatocellular carcinoma patients with Child‐Pugh A following hepatectomy

Miyata, Tatsunori; Yamashita, Yo‐ichi; Arima, Kei; Higashi, Taishi; Hayashi, Hiromitsu; Imai, Katsunori; Nitta, Hidetoshi; Chikamoto, Akira; Beppu, Teruhiko; Baba, Hideo

doi:10.1002/ags3.12498

Cited by 8 publications

(2 citation statements)

References 29 publications

(65 reference statements)

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“…The ALBI grade is divided into three levels. The higher the ALBI grade, the worse the liver function (39,40). After analyzing the relationship between MC1 value and (D) ROC curve analysis of MC1 was performed to differentiate healthy individuals from CRC patients.…”

Section: The Prognostic Role Of Mc1 In Crc Patientsmentioning

confidence: 99%

Circulating Glycan Monosaccharide Composite-Based Biomarker Diagnoses Colorectal Cancer at Early Stages and Predicts Prognosis

Wang

Huang

et al. 2022

Front. Oncol.

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IntroductionEarly diagnosis could lead to a cure of colorectal cancer (CRC). Since CRC is related to aging and lifestyles, we tested if the environmental information-enriched monosaccharide composite (MC) of circulating glycans could serve as an early diagnostic biomarker for CRC. Meanwhile, we evaluated its role in predicting prognosis.MethodsHPAEC-PAD was used to quantify glycan monosaccharide compositions from a total of 467 serum samples including CRC patients, colorectal adenoma (CRA) patients and healthy individuals. Two diagnostic model was constructed by logistic regression analysis. The diagnostic performance of the two models was verified in the retrospective validation group and the prospective validation group. The prognostic performance of the model was assessed by survival analysis.ResultsThe concentrations of monosaccharides in serum were significantly higher in CRA and CRC patients than in healthy individuals. Two diagnostic models were constructed: MC1 was used to distinguish between healthy individuals and CRC; MC2 was used to distinguish between healthy individuals and CRA. Area under receptor operating characteristic curve (AUC) of MC2 and MC1 was 0.8025 and 0.9403 respectively. However, the AUC of CEA between healthy individuals and CRC was 0.7384. Moreover, in early stage of CRC (without lymph node metastasis), the positive rates of CEA and MC1 were 28% and 80%, respectively. The follow-up data showed that the increased MC1 value was associated with poor survival in patients with CRC (p=0.0010, HR=5.30).DiscussionThe MC1 model is superior to CEA in the diagnosis of CRC, especially in the early diagnosis. MC1 can be used for predicting prognosis of CRC patients, and elevated MC1 values indicate poor survival.

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Section: The Prognostic Role Of Mc1 In Crc Patientsmentioning

confidence: 99%

Circulating Glycan Monosaccharide Composite-Based Biomarker Diagnoses Colorectal Cancer at Early Stages and Predicts Prognosis

Wang

Huang

et al. 2022

Front. Oncol.

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“…Hepatocellular carcinoma (HCC) is the sixth most common cancer in the world and is the fourth leading cause of cancer-related deaths 1 – 3 . Treatment strategies for HCC have significantly evolved with advances in diagnostic modalities, surgical techniques, and systemic therapies 1 , 2 , 4 .…”

Section: Introductionmentioning

confidence: 99%

RNF31 promotes proliferation and invasion of hepatocellular carcinoma via nuclear factor kappaB activation

Hoshino,

Nakazawa,

Yokobori

et al. 2024

Sci Rep

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RNF31 is a multifunctional RING finger protein implicated in various inflammatory diseases and cancers. It functions as a core component of the linear ubiquitin chain assembly complex (LUBAC), which activates the nuclear factor kappaB (NF-κB) pathway via the generation of the Met1-linked linear ubiquitin chain. We aimed to clarify the role of RNF31 in the pathogenesis of hepatocellular carcinoma (HCC) and its relevance as a therapeutic target. High RNF31 expression in HCC, assessed by both immunohistochemistry and mRNA levels, was related to worse survival rates among patients with HCC. In vitro experiments showed that RNF31 knockdown in HCC cell lines led to decreased cell proliferation and invasion, as well as suppression of tumor necrosis factor (TNF)-α-induced NF-κB activation. Treatment with HOIPIN-8, a specific LUBAC inhibitor that suppresses RNF31 ubiquitin ligase (E3) activity, showed similar effects, resulting in decreased cell proliferation and invasion. Our clinical and in vitro data showed that RNF31 is a prognostic factor for HCC that promotes tumor aggressiveness via NF-κB activation.

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The complication-overall survival (CompOS) risk tool predicts risk of a severe postoperative complications relative to long-term survival among patients with primary liver cancer

Endo,

Tsilimigras,

Woldesenbet

et al. 2024

Journal of Gastrointestinal Surgery

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Alteration of prognostic efficacy of albumin‐bilirubin grade and Child‐Pugh score according to liver fibrosis in hepatocellular carcinoma patients with Child‐Pugh A following hepatectomy

Cited by 8 publications

References 29 publications

Circulating Glycan Monosaccharide Composite-Based Biomarker Diagnoses Colorectal Cancer at Early Stages and Predicts Prognosis

Circulating Glycan Monosaccharide Composite-Based Biomarker Diagnoses Colorectal Cancer at Early Stages and Predicts Prognosis

RNF31 promotes proliferation and invasion of hepatocellular carcinoma via nuclear factor kappaB activation

The complication-overall survival (CompOS) risk tool predicts risk of a severe postoperative complications relative to long-term survival among patients with primary liver cancer

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