Alteration of Platelet Cyclic AMP (cAMP) by Ethanol

Cowan, Dale H.; Kikta, M.; Baunach, D.

doi:10.1055/s-0039-1680810

Cited by 2 publications

(1 citation statement)

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“…Ingestion of high doses of ethanol, even without significant liver disease, may induce a storage pool-type defect; decreased storage pool ADP and adenosine triphosphate (ATP) are induced by ethanol alone, and cyclic adenosine mono- phosphate (cAMP) levels are also reduced by ethanolinduced inhibition of adenylate cyclase. 98,99,101 As another insult, ethanol inhibits thromboxane A 2 synthesis. 98,99 Ethanol also inhibits monoamine oxidase but causes a 50 to 100% increase in intraplatelet serotonin; the significance of this is unknown.…”

Section: Platelet Dysfunction In Liver Diseasementioning

confidence: 99%

Platelet Function Defects: A Clinical Review

Bick¹

1992

Semin Thromb Hemost

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Platelet dysfunction, especially acquired forms, are common causes of hemorrhage, especially in association with trauma and surgery. Although the hereditary platelet function defects are generally quite rare, hereditary storage pool disease is common enough to be suspected in an individual, usually a child, with characteristic historical and clinical findings. The acquired platelet function defects, especially those resulting from drugs, are very common and should promptly be suspected in patients developing easy and spontaneous bruising, mild to moderate mucosal membrane hemorrhage, or unexplained bleeding associated with trauma or surgery. The template bleeding time is generally useful as a screening test of platelet function, but a normal template bleeding time, in the presence of a suggestive history, suggestive clinical findings, or in the patient frankly bleeding, is not reliable and platelet aggregation or lumi-aggregation should be done in appropriate clinical situations. The mainstay of therapy for essentially all these defects, if bleeding is significant, is the liberal infusion of appropriate numbers of platelet concentrates. The acquired platelet function defects, of course, should also be managed by attempts to treat or control the underlying disease, if possible, and offending drugs or potentially offending drugs should promptly be discontinued.

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Section: Platelet Dysfunction In Liver Diseasementioning

confidence: 99%