Alteration of muscle fiber composition linking to insulin resistance and hypertension in fructose-fed rats

Higashiura, Katsuhiro; Ura, Nobuyuki; Takada, Tatsuro; Agata, Jun; Yoshida, Hiroyuki; Miyazaki, Yoshinori; Shimamoto, Kazuaki

doi:10.1016/s0895-7061(99)00025-4

Cited by 35 publications

(32 citation statements)

References 25 publications

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“…This report suggested the possibility that the decrease in glycogen content in the fibers during starvation led to conversion of muscle fiber type in response to the extreme nutritional environment. Recently Higashiura et al (14) reported that high fructose-fed rats (insulin-resistance diabetogenic diet) increased the percentage of type IIa at the expense of a decrease in type I in soleus, suggesting the alteration of muscle fiber composition linkage to insulin resistance and hypertension. Kikuzawa et al reported that ingestion of L-arabinose increased type I fibers in the rectus femoris muscle in rats (40).…”

Section: Discussionmentioning

confidence: 99%

“…They only suggested the physiological role of carnitine as a buffer agent neutralizing the excess acetyl group occurring during prolonged exercise in type I fibers. To our knowledge, few studies have been so far conducted on the effect of nutrients such as carnitine on muscle fiber type transformation, although undernutrition has been shown to induce an increase in the proportion of slow type fiber (13)(14)(15).…”

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confidence: 99%

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Beef Extract Supplementation Increases Leg Muscle Mass and Modifies Skeletal Muscle Fiber Types in Rats

Yoshihara

Wakamatsu

Kawabata

et al. 2006

J Nutr Sci Vitaminol

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SummaryThe objective of this research was to investigate the effects of beef extract on fat metabolism, muscle mass and muscle fiber types in rats. We also investigated the synergetic effect of endurance exercise. Twenty-four male rats weighing about 270 g were assigned to two diets containing 0 or 6% beef extract (BE). Half the rats fed each diet were subjected to compulsory exercise (CE) for 30 min every other day. After 4 weeks feeding, the blood was collected and various organs were dissected. The muscle fiber type of the soleus and extensor digitorum longus (EDL) muscles were evaluated by histochemical and electrophoretical analyses. Rats supplemented with BE showed a decrease in fat content in liver and abdomen and an increase in the activity of carnitine palmitoyl transferase II in liver. BE as well as exercise increased the relative weights of both soleus and EDL. BE alone and BE plus CE did not affect the distribution of muscle fiber types in soleus. BE without exercise decreased in type IIb of EDL from 54% to 44% with compensatory increase in type IIa from 41% to 49% and type I from 5% to 7% compared with the nonsupplemented, nonexercised control group. No synergetic effect on a fast to slow fiber conversion due to the combination of BE and CE was detected. Thus, BE supplement increased muscle mass and slow type fiber in EDL. The effects of BE supplement on muscle characteristics were similar to those of exercise. Key Words beef extract, fat metabolism, muscle fiber type, muscle mass, L -carnitine A great deal of research has been done to elucidate the general nutritional value of beef on the growth of human subjects and the effects of protein quality and exercise on the growth and protein metabolism of animals and human beings ( 1-3 ). However, existing information about the nutritional effects of beef extract on muscle metabolism is not sufficient.Skeletal muscle is composed of at least three fiber types on the basis of their contractile and energy metabolic properties; type I fibers exhibit an aerobic energy metabolism (slow-twitch fiber), type IIb fibers are predominantly glycolytic (fast-twitch fiber) and type IIa fibers are the intermediate type exhibiting both oxidative and glycolytic metabolisms. Lipids are easily accumulated in type I fibers ( 4 ), while glycogen depletion occurs primarily in the type II ( 5 ). It is well known that cross-reinnervation, electrical stimulation or exercise evokes the fiber type conversion, although the molecular mechanisms mediating the transformation are not clearly elucidated ( 6 , 7 ). This means that skeletal muscle cells possess a capacity to respond and adapt to metabolic changes imposed by physical stimulation or neural stimulation. Concretely, endurance exercise requiring the consumption of oxygen stimulates a shift to the slow twitch, oxidative muscle fibers ( 8 ). The fiber types of adult skeletal muscle are closely related to energy metabolic characteristics as described above. Nutrition-induced regulation in mRNA levels for a number of metabolic gene...

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Beef Extract Supplementation Increases Leg Muscle Mass and Modifies Skeletal Muscle Fiber Types in Rats

Yoshihara

Wakamatsu

Kawabata

et al. 2006

J Nutr Sci Vitaminol

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“…[135][136][137] Interestingly, expression of slow-twitch fibers was decreased in type 2 diabetes, which partially contributed to attenuated FAO and insulin sensitivity. [138][139][140] Since rexinoids increased FAO, we further tested the effects of these drugs on fiber-type expression in skeletal muscles of db/db mice. Indeed, treatment of db/db mice with rexinoids increased the expression of slow-twitch biomarkers such as myoglobin and troponin I slow (Narkar et al, unpublished observations).…”

Section: Regulation Of Genes Related To Oxidative Slow-twitch Phenotypementioning

confidence: 99%

Retinoid X receptors: X-ploring their (patho)physiological functions

Szántó

Narkar²,

Shen³

et al. 2004

Cell Death Differ

251

242

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Retinoid X receptor (RXR) belongs to a family of ligandactivated transcription factors that regulate many aspects of metazoan life. A class of nuclear receptors requires RXR as heterodimerization partner for their function. This places RXR in the crossroad of multiple distinct biological pathways. This and the fact that the debate on the endogenous ligand requirement for RXR is not yet settled make RXR still an enigmatic transcription factor. Here, we review some of the biology of RXR. We place RXR into the evolution of nuclear receptors, review structural details and ligands of the receptor. Then processes regulated by RXR are discussed focusing on the developmental roles deduced from studies on knockout animals and metabolic roles in diseases such as diabetes and atherosclerosis deduced from pharmacological studies. Finally, aspects of RXR's involvement in myeloid differentiation and apoptosis are summarized along with issues on RXR's suitability as a therapeutic target.

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“…Insulin resistance in skeletal muscle is thought to contribute to the development of hypertension. [26][27][28][29][30][31] On the other hand, recent studies have shown that IR can occur separately in the liver and in skeletal muscles. 32 Current clinical indexes of insulin sensitivity (IS) are not specific to IS in the liver or that in the skeletal muscle.…”

Section: Introductionmentioning

confidence: 99%

Matsuda–DeFronzo insulin sensitivity index is a better predictor than HOMA-IR of hypertension in Japanese: the Tanno–Sobetsu study

et al. 2011

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Here we examined whether the Matsuda-DeFronzo insulin sensitivity index (ISI-M) is more efficient than the homeostasis model assessment of insulin resistance (HOMA-IR) for assessing risk of hypertension. Cross-sectional and longitudinal analyses were conducted using normotensive subjects who were selected among 1399 subjects in the Tanno-Sobetsu cohort. In the cross-sectional analysis (n ¼ 740), blood pressure (BP) level was correlated with HOMA-IR and with ISI-M, but correlation coefficients indicate a tighter correlation with ISI-M. Multiple linear regression analysis adjusted by age, sex, body mass index (BMI) and serum triglyceride level (TG) showed contribution of ISI-M and fasting plasma glucose, but not of HOMA-IR. In the longitudinal analysis (n ¼ 607), 241 subjects (39.7%) developed hypertension during a 10-year follow-up period, and multiple logistic regression indicated that age, TG, systolic BP and ISI-M, but not HOMA-IR, were associated with development of hypertension. In subjects o60 years old, odds ratio of new-onset hypertension was higher in the low ISI-M group (ISI-M, less than the median) than in the high ISI-M group for any tertile of BMI. In conclusion, ISI-M is a better predictor of hypertension than is HOMA-IR. Non-hepatic IR may be a determinant, which is independent of TG, BP level and BMI, of the development of hypertension.

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Alteration of muscle fiber composition linking to insulin resistance and hypertension in fructose-fed rats

Cited by 35 publications

References 25 publications

Beef Extract Supplementation Increases Leg Muscle Mass and Modifies Skeletal Muscle Fiber Types in Rats

Beef Extract Supplementation Increases Leg Muscle Mass and Modifies Skeletal Muscle Fiber Types in Rats

Retinoid X receptors: X-ploring their (patho)physiological functions

Matsuda–DeFronzo insulin sensitivity index is a better predictor than HOMA-IR of hypertension in Japanese: the Tanno–Sobetsu study

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