Alteration of Micronutrient Status in Compensated and Decompensated Liver Cirrhosis

Kar, Kaushik; Dasgupta, Anindya; Bhaskar, M. Vijaya; Sudhakar, K.

doi:10.1007/s12291-013-0349-5

Cited by 11 publications

(7 citation statements)

References 25 publications

(32 reference statements)

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“…A recent study compared serum trace element levels in patients with compensated versus decompensated liver cirrhosis. Zn levels were lower in the decompensated group 64 . In a placebo‐controlled trial of Zn treatment of patients with liver cirrhosis, hyperammonemia, and hypozincemia, a significant reduction in ammonia levels was observed in the treatment group 65 .…”

Section: Zn Deficiencymentioning

confidence: 93%

Zinc

Livingstone

2015

Nut in Clin Prac

221

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The essential trace element zinc (Zn) has a large number of physiologic roles, in particular being required for growth and functioning of the immune system. Adaptive mechanisms enable the body to maintain normal total body Zn status over a wide range of intakes, but deficiency can occur because of reduced absorption or increased gastrointestinal losses. Deficiency impairs physiologic processes, leading to clinical consequences that include failure to thrive, skin rash, and impaired wound healing. Mild deficiency that is not clinically overt may still cause nonspecific consequences, such as susceptibility to infection and poor growth. The plasma Zn concentration has poor sensitivity and specificity as a test of deficiency. Consequently, diagnosis of deficiency requires a combination of clinical assessment and biochemical tests. Patients receiving parenteral nutrition (PN) are susceptible to Zn deficiency and its consequences. Nutrition support teams should have a strategy for assessing Zn status and optimizing this by appropriate supplementation. Nutrition guidelines recommend generous Zn provision from the start of PN. This review covers the physiology of Zn, the consequences of its deficiency, and the assessment of its status, before discussing its role in PN.

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Section: Zn Deficiencymentioning

confidence: 93%

Zinc

Livingstone

2015

Nut in Clin Prac

221

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“…Two studies have found that magnesium concentration was not significantly different between patients with and without liver cirrhosis and no significant correlation was found with the Child-Pugh score[ 109 , 110 ]. One study found magnesium levels were significantly lower in cirrhotic patients compared to controls, but there was no difference between compensated and decompensated patients[ 111 ]. Conversely, another study demonstrated a negative correlation between serum magnesium and Child-Pugh score, and lower levels of magnesium among patients with cirrhosis compared to controls[ 112 ].…”

Section: Micronutrient Status and Recommended Supplementation In Patimentioning

confidence: 99%

Nutritional issues in patients with obesity and cirrhosis

Schiavo¹,

Busetto²,

Cesaretti³

et al. 2018

WJG

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Obesity and metabolic syndrome are considered as responsible for a condition known as the non-alcoholic fatty liver disease that goes from simple accumulation of triglycerides to hepatic inflammation and may progress to cirrhosis. Patients with obesity also have an increased risk of primary liver malignancies and increased body mass index is a predictor of decompensation of liver cirrhosis. Sarcopenic obesity confers a risk of physical impairment and disability that is significantly higher than the risk induced by each of the two conditions alone as it has been shown to be an independent risk factor for chronic liver disease in patients with obesity and a prognostic negative marker for the evolution of liver cirrhosis and the results of liver transplantation. Cirrhotic patients with obesity are at high risk for depletion of various fat-soluble, water-soluble vitamins and trace elements and should be supplemented appropriately. Diet, physical activity and protein intake should be carefully monitored in these fragile patients according to recent recommendations. Bariatric surgery is sporadically used in patients with morbid obesity and cirrhosis also in the setting of liver transplantation. The risk of sarcopenia, micronutrient status, and the recommended supplementation in patients with obesity and cirrhosis are discussed in this review. Furthermore, the indications and contraindications of bariatric surgery-induced weight loss in the cirrhotic patient with obesity are discussed.

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“…They analyzed magnesium levels in the serum of compensated (n=34) and decompensated (n=31) liver cirrhosis patients and compared with that of healthy control group (n=36) by post hoc ANOVA. Although a significant decrease in serum magnesium levels was found in cirrhosis patients overall (both Group I and 2) in comparison to the control subjects (p<0.05), no such difference was observed between the compensated and decompensated groups within the case population (p>0.05) [12].…”

Section: Discussionmentioning

confidence: 75%

Prevalence of Hypomagnesemia in Cirrhosis of Liver and Its Association With Severityof the Disease

VEENA

JAMES

2022

Asian J Pharm Clin Res

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Objectives: The objectives of the study are as follows: (1) To study the prevalence of hypomagnesemia in liver cirrhosis patients. (2) To evaluate association between hypomagnesemia and severity of liver disease. Methods: It was a cross-sectional study for 1 year. Seventy-one liver cirrhosis patients attending medicine OPD and those admitted in ward, ICU at Government Medical College, Kozhikode. Informed consent was taken from 71 liver cirrhosis patients. Samples for serum magnesium, total bilirubin, and albumin were collected from cases in blood collection tube without anticoagulant and centrifuged to get serum. Estimation of magnesium was done using colorimetric end point method. Estimation of total bilirubin was done using Diazo method and that of serum albumin with Bromocresol Green dye method. SPSS (Version 22.0) was used for analysis. Results: Among the study patients, hypomagnesemia was prevalent in majority (71.8%) of cases. The mean magnesium levels between different grades of liver cirrhosis were statistically significant at p=0.001. Levels of serum magnesium were significantly decreased with advancement of liver cirrhosis. Conclusion: Hypomagnesemia is prevalent in liver cirrhosis patients. Serum magnesium decreases significantly with severity of liver cirrhosis. A routine assessment of serummagnesium in liver cirrhosis patients may be effective in management protocol ofliver cirrhosis.

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Alteration of Micronutrient Status in Compensated and Decompensated Liver Cirrhosis

Cited by 11 publications

References 25 publications

Zinc

Zinc

Nutritional issues in patients with obesity and cirrhosis

Prevalence of Hypomagnesemia in Cirrhosis of Liver and Its Association With Severityof the Disease

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