Alteration of lipid profile and value of lipids in the prediction of the length of hospital stay in COVID‐19 pneumonia patients

Chen, Qin; Huang, Meizhu; Zhao, Zhanzheng; Luo, Yun

doi:10.1002/fsn3.1907

Cited by 28 publications

(55 citation statements)

References 24 publications

(25 reference statements)

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“…Overall, our observations align with previous reports, wherein low HDL and LDL levels have been associated with disease severity and progression [ 1 , 2 ] as well as with increased length of hospitalization [ 4 ].…”

Section: Discussionsupporting

confidence: 92%

“…Several studies have explored the alterations in lipid profile in the setting of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, reporting a state of hypolipidemia during active infection [ [1] , [2] , [3] ], with normalization after recovery [ 4 ]. These changes have been attributed to inflammation, liver dysfunction, increased vascular permeability [ 3 ] and, interestingly, the interplay between cholesterol and viral replication [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Alterations in the lipid profile associate with a dysregulated inflammatory, prothrombotic, anti-fibrinolytic state and development of severe acute kidney injury in coronavirus disease 2019 (COVID-19): A study from Cincinnati, USA

Henry

Szergyuk

Oliveira

et al. 2021

Diabetes & Metabolic Syndrome: Clinical Research & Revi

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Background and aims Reduction of atherogenic lipoproteins is often the ultimate goal of nutritional interventions, however this is complicated given that hypolipidemia is frequently observed in coronavirus disease 2019 (COVID-19) patients. We aimed to explore the association of hypolipidemia with patient outcomes in terms of immunothrombosis and multiorgan injury, focusing on specialized apolipoproteins apo A1 and apo B. Methods Lipid profiles of 50 COVID-19 patients and 30 sick controls presenting to the Emergency Department (ED) were measured in this prospective observational study. The primary outcome was development of severe acute kidney injury (AKI). Need for hospitalization and ICU admission were secondary outcomes. Lipoproteins were analyzed for independent association with serum creatinine (SCr) increase ratio and correlated with a wide panel of biomarkers. Results COVID-19 cohort had significantly lower apo A1 (p = 0.006), and higher apo B/apo A1 ratio (p = 0.041). Patients developing severe AKI had significantly lower LDL-C (p = 0.021). Apo B/apo A1 was associated with 2.25-fold decrease in serum SCr increase ratio, while LDL-C with a 1.5% decrease. Hypolipidemia correlated with low plasminogen, ADAMTS13 activity/VWF:Ag, and high inflammatory biomarkers (CRP, IL-6, IL-8, IL-10), plasminogen activator inhibitor-1 (PAI-1), ED creatinine, and SCr increase ratio. Conclusion Although favored in dietetics, findings of a low LDL-C in COVID-19 patients should be alarming in light of our observations. Low apo B/apo A1 ratio and LDL-C are predictive of renal deterioration in COVID-19 patients, and low LDL-C in particular may potentially serve to indicate COVID-19 related AKI driven by disrupted fibrinolysis and a secondary thrombotic microangiopathy-like process.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Alterations in the lipid profile associate with a dysregulated inflammatory, prothrombotic, anti-fibrinolytic state and development of severe acute kidney injury in coronavirus disease 2019 (COVID-19): A study from Cincinnati, USA

Henry

Szergyuk

Oliveira

et al. 2021

Diabetes & Metabolic Syndrome: Clinical Research & Revi

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“…As expected, apolipoprotein A-I and B were also decreased ( 39 , 40 , 41 ). With recovery from COVID-19 infection the lipid levels return towards levels present prior to infection ( 28 , 29 , 30 , 42 , 43 ). As expected, the greater the severity of the illness the greater the reduction in LDL-C and/or HDL-C levels ( 29 , 31 , 32 , 33 , 34 , 35 , 36 , 38 , 42 , 44 , 45 ).…”

Section: Effect Of Infections On Lipid and Lipoproteinsmentioning

confidence: 96%

“…With recovery from COVID-19 infection the lipid levels return towards levels present prior to infection ( 28 , 29 , 30 , 42 , 43 ). As expected, the greater the severity of the illness the greater the reduction in LDL-C and/or HDL-C levels ( 29 , 31 , 32 , 33 , 34 , 35 , 36 , 38 , 42 , 44 , 45 ). LDL-C and HDL-C levels are inversely correlated with C-reactive protein (CRP) levels i.e., the higher the CRP levels the lower the LDL-C or HDL-C level ( 28 , 29 , 31 , 45 ).…”

Section: Effect Of Infections On Lipid and Lipoproteinsmentioning

confidence: 96%

The bidirectional link between HDL and COVID-19 infections

Feingold

2021

Journal of Lipid Research

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“…The COVID-19 receptor, angiotensin-converting enzyme 2 (ACE2), is considered to be a chief receptor of the viral spike protein and is important for infection [20,21]. The ACE2 protein in the biliary system, colon and liver is present at high levels [22] and the RNA shedding is well known in the GI tract [23].…”

Section: Effect Of Covid-19 On Liver Functionmentioning

confidence: 99%

COVID- 19 and abnormalities of some biochemical tests: review

Abdulbari

Al-Saadi

2021

QAJ

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Coronaviruses are a group of viruses proven to affect both respiratory and gastrointestinal diseases in varied animal and human organisms. More than 100 million people worldwide are currently believed to have been infected and more than two million people have died and induced clinical syndrome of coronavirus disease in 2019.It's (COVID-19). The purpose of this analysis was to determine whether multiple biochemical test derangements are a common feature in patients with reported COVID-19 infection, to determine the relationship between the deranged liver test and lipoprotein with COVID-19 outcome or severity, and to determine whether liver failure or dyslipidemia is a common feature of COVID-19. This review was conducted using the Web of Science, PubMed and Scopus databases. English case-series and cross-sectional papers were considered, describing the currently offered findings on the relationship between certain biomedical tests and COVID-19 infections. To summarize, COVID-19 may have a severe tendency in older patients biochemical indexes (decrease albumin, decrease LDL-c, HDL-c, and TC, increased CRP, increased AST, increased LDH and CK) could be used as indicators to predict the severity of the disease.

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Alteration of lipid profile and value of lipids in the prediction of the length of hospital stay in COVID‐19 pneumonia patients

Cited by 28 publications

References 24 publications

Alterations in the lipid profile associate with a dysregulated inflammatory, prothrombotic, anti-fibrinolytic state and development of severe acute kidney injury in coronavirus disease 2019 (COVID-19): A study from Cincinnati, USA

Alterations in the lipid profile associate with a dysregulated inflammatory, prothrombotic, anti-fibrinolytic state and development of severe acute kidney injury in coronavirus disease 2019 (COVID-19): A study from Cincinnati, USA

The bidirectional link between HDL and COVID-19 infections

COVID- 19 and abnormalities of some biochemical tests: review

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