Alteration of lipid composition of rat thymus during thymic atrophy by whole-body X-irradiation

Park, Heung Soon; Kim, Sungyeul; Lee, Youngkyun; Choi, Myung Sun; Choi, Myung-Un

doi:10.1080/09553000600617189

Cited by 9 publications

(4 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have reported that radiation induces acute thymic atrophy and reduces the total number of thymocytes[18],[19], especially DP thymocytes[4]. Our results are consistent with these findings.…”

Section: Discussionsupporting

confidence: 93%

X-ray irradiation selectively kills thymocytes of different stages and impairs the maturation of donor-derived CD4+CD8+ thymocytes in recipient thymus

Cai

Jin

et al. 2012

J Biomed Res

View full text Add to dashboard Cite

The aim of the present study was to determine whether the sensitivity of thymocytes to X-ray radiation depends on their proliferative states and whether radiation impairs the maturation of donor-derived thymocytes in recipient thymus. We assigned 8-week-old C57BL/6J mice into three treatment groups: 1) untreated; 2) X-ray radiation; 3) X-ray radiation plus bone marrow transplantation with donor bone marrow cells from transgenic mice expressing enhanced green fluorescent protein (GFP) on a universal promoter. After 4 weeks, the size of the thymus, the number and proliferation of thymocytes and ratios of different stage thymocytes were analyzed by immunohistochemistry and flow cytometry. The results showed that: 1) CD4+CD8+ thymocytes were more sensitive to X-ray radiation-induced cell death than other thymocytes; 2) the proliferative capacity of CD4+CD8+ thymocytes was higher than that of other thymocytes; 3) the size of the thymus, the number of thymocytes and ratios of thymocytes of different stages in irradiated mice recovered to the normal level of untreated mice by bone marrow transplantation; 4) the ratio of GFP-positive CD4+CD8+ thymocytes increased significantly, whereas the ratio of GFP-positive CD4+ or CD8+ thymocytes decreased significantly. These results indicate that the degree of sensitivity of thymocytes to X-ray radiation depends on their proliferative states and radiation impairs the maturation of donor-derived CD4+CD8+ thymocytes in recipient thymus.

show abstract

Section: Discussionsupporting

confidence: 93%

X-ray irradiation selectively kills thymocytes of different stages and impairs the maturation of donor-derived CD4+CD8+ thymocytes in recipient thymus

Cai

Jin

et al. 2012

J Biomed Res

View full text Add to dashboard Cite

show abstract

“…A few data on changes in the lipid metabolism in the thymic cells under the action of ionizing radiation vary significantly depending on the dose, irradiation conditions, study periods, etc. (Miras et al 1968, Kolomiytseva et al 1987, Ahlers et al 1992, Kulagina 1997, Park et al 2006). …”

Section: Discussionmentioning

confidence: 93%

Modifying effects of low-intensity extremely high-frequency electromagnetic radiation on content and composition of fatty acids in thymus of mice exposed to X-rays

Gapeyev

Aripovsky

Кулагина

2015

International Journal of Radiation Biology

View full text Add to dashboard Cite

show abstract

“…Previous studies have shown that the thymus is susceptible to whole body irradiation [ 42 , 43 , 44 , 45 ]. We found that the thymus was also sensitive to BLCIR, as demonstrated by atrophy, thymic apoptosis, and abnormal T-cell development in rats receiving BLCIR.…”

Section: Discussionmentioning

confidence: 99%

Carbon Ion Irradiated Neural Injury Induced the Peripheral Immune Effects in Vitro or in Vivo

Lei

Zhao

et al. 2015

IJMS

View full text Add to dashboard Cite

Carbon ion radiation is a promising treatment for brain cancer; however, the immune system involved long-term systemic effects evoke a concern of complementary and alternative therapies in clinical treatment. To clarify radiotherapy caused fundamental changes in peripheral immune system, examinations were performed based on established models in vitro and in vivo. We found that brain-localized carbon ion radiation of neural cells induced complex changes in the peripheral blood, thymus, and spleen at one, two, and three months after its application. Atrophy, apoptosis, and abnormal T-cell distributions were observed in rats receiving a single high dose of radiation. Radiation downregulated the expression of proteins involved in T-cell development at the transcriptional level and increased the proportion of CD3+CD4−CD8+ T-cells in the thymus and the proportion of CD3+CD4+CD8− T-cells in the spleen. These data show that brain irradiation severely affects the peripheral immune system, even at relatively long times after irradiation. In addition, they provide valuable information that will implement the design of biological-based strategies that will aid brain cancer patients suffering from the long-term side effects of radiation.

show abstract

Alteration of lipid composition of rat thymus during thymic atrophy by whole-body X-irradiation

Abstract: Lipid analysis shows that the thymic atrophy by X-irradiation was accompanied by a significant change in thymic lipids. This in vivo result opens up new vistas of the role of lipids in apoptosis and phagocytosis during thymic atrophy.

Cited by 9 publications

References 28 publications

X-ray irradiation selectively kills thymocytes of different stages and impairs the maturation of donor-derived CD4+CD8+ thymocytes in recipient thymus

X-ray irradiation selectively kills thymocytes of different stages and impairs the maturation of donor-derived CD4+CD8+ thymocytes in recipient thymus

Modifying effects of low-intensity extremely high-frequency electromagnetic radiation on content and composition of fatty acids in thymus of mice exposed to X-rays

Carbon Ion Irradiated Neural Injury Induced the Peripheral Immune Effects in Vitro or in Vivo

Contact Info

Product

Resources

About