Alteration of Interferon Gamma (IFN-γ) in Human Plasma with Graded Physical Activity

Vijayaraghava, Ambarish; Radhika, K

doi:10.7860/jcdr/2014/9502.4440

Cited by 18 publications

(20 citation statements)

References 22 publications

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“…Similar to the increase in IL-10, the concurrent small increase of IFN-γ in both the CME and CSE exercise groups (and unchanged in the controls) seems to be beneficial, since this biomarker is considered as an anti-inflammatory cytokine in low concentrations. Regular moderate exercise (as was the case in this study) and not intense exercise has beneficial effects on health by way of increasing satisfactory plasma IFN-γ levels [57].…”

Section: Immune Markersmentioning

confidence: 61%

The Mediating Effect of Different Exercise Programs on the Immune Profile of Frail Older Women with Cognitive Impairment

Furtado

Chupel

Minuzzi

et al. 2020

CPD

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Background: Frail individuals experience an accelerated immunosenescence, and exercise has been identified as a therapy to promote a better inflammatory environment. Objective: To analyze the effects of 28-weeks of two different exercise protocols on the functional fitness and immune profiles of institutionalized pre-frail and frail women with mild cognitive impairment. Methods: Participants residing in care homes (n=60, 81±7.84 years old) were randomized into three groups: a chair elastic band muscle-strength exercise (CSE, n=21; 81±4.79), a chair multimodal exercise (CME, n=20; 80±8.19), and a control non-exercise (CGne, n=19; 80±10.01). Both CME and CSE groups performed progressive circuit-training exercise sessions. The controls did not change their usual lifestyle. The Fried protocol and the Mini-Mental State Examination questionnaire were used to identify the frail subgroups and the participants with mild cognitive impairment. Data for anti and pro-inflammatory markers and physical fitness were analyzed pre and post-interventions. Results: After the intervention, a significant effect of time and time by group for sIgA and time by group for IL- 10 levels were found (p > 0.05). Within-group analysis showed a significant moderate decrease in the TNF-α to IL-10 ratio for the CME group and an increase in the controls (p > 0.05) and a slight reduction in the IL-6 and IL- 1β concentrations. The controls showed a negative trend towards a decrease in physical fitness and a trend for increased levels in the pro-inflammatory markers IL-6 and IL-1β. Conclusions: The evidence regarding the use of systematic and moderate long-term exercise as therapy for promoting a better balance between pro- and anti-inflammatory environments and a decrease in the inflammatory index for the CME group were the most promising results from this study.

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Section: Immune Markersmentioning

confidence: 61%

The Mediating Effect of Different Exercise Programs on the Immune Profile of Frail Older Women with Cognitive Impairment

Furtado

Chupel

Minuzzi

et al. 2020

CPD

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“…Regular Ex modulates another novel INF pathway, with a probable COVID-19 prevention activity. Ex is beneficial for maintaining the improvement of the immune status, associated with a rise in IFN-2 (γ) in the plasma [ 25 ]. Thus, regular moderate Ex seems to modulate its release and increase its levels to those necessary for the human body to maintain good health [ 26 ].…”

Section: Intervention Through Physical Exercise On the Immune Funcmentioning

confidence: 99%

“…Migration of CD4 + and CD8 + T cells (ex vivo) reduced to supernatants of human rhinovirus (HRV)-infected bronchial epithelial cell line 1 h after completing a 2 h of running with an intensity of 60% VO 2 max [ 51 ]. However, some T cells (CD4 + , CD8 + , and γδ T cells) with a higher migration capacity and more efficient power appear to fall during Ex recovery and may have gone into the peripheral blood earlier [ 25 ]. Concretely, Simpson et al [ 52 ] have observed T cells’ activation and proliferation after exercise.…”

Section: Intervention Through Physical Exercise On the Immune Funcmentioning

confidence: 99%

Physical Exercise as a Multimodal Tool for COVID-19: Could It Be Used as a Preventive Strategy?

Fernández-Lázaro

González-Bernal

Sánchez-Serrano³

et al. 2020

IJERPH

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or coronavirus disease 2019 (COVID-19) is a novel coronavirus not previously recognized in humans until late 2019. On 31 December 2019, a cluster of cases of pneumonia of unspecified etiology was reported to the World Health Organization in China. The availability of adequate SARS-CoV-2 drugs is also limited, and the efficacy and safety of these drugs for COVID-2019 pneumonia patients need to be assessed by further clinical trials. For these reasons, there is a need for other strategies against COVID-19 that are capable of prevention and treatment. Physical exercise has proven to be an effective therapy for most chronic diseases and microbial infections with preventive/therapeutic benefits, considering that exercise involves primary immunological mediators and/or anti-inflammatory properties. This review aimed to provide an insight into how the implementation of a physical exercise program against COVID-19 may be a useful complementary tool for prevention, which can also enhance recovery, improve quality of life, and provide immune protection against SARS-CoV-2 virus infection in the long term. In summary, physical exercise training exerts immunomodulatory effects, controls the viral gateway, modulates inflammation, stimulates nitric oxide synthesis pathways, and establishes control over oxidative stress.

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“…Work from our laboratory shows that exposure of rats to an environmental enrichment paradigm triggers release of serum-derived extracellular vesicles (EVs) that promote myelination/remyelination and reduce measures of oxidative stress [5,6]. Analogous EVs can be produced ex vivo by stimulating bone marrow-derived dendritic cell cultures with interferon gamma (IFNγ), a pro-inflammatory cytokine that is phasically increased with environmental enrichment [7].…”

Section: Introductionmentioning

confidence: 99%

IFNγ-stimulated dendritic cell extracellular vesicles can be nasally administered to the brain and enter oligodendrocytes

2021

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Extracellular vesicles secreted from IFNγ-stimulated rat dendritic cells (referred to here as IFNγ-DC-EVs) contain miRNAs which promote myelination (including but not limited to miR-219), and preferentially enter oligodendrocytes in brain slice cultures. IFNγ-DC-EVs also increase myelination when nasally administered to naïve rats. While we can infer that these extracellular vesicles enter the CNS from functional studies, here we demonstrate biodistribution throughout the brain after nasal delivery by way of imaging studies. After nasal administration, Xenolight DiR-labelled IFNγ-DC-EVs were detected 30 minutes later throughout the brain and the cervical spinal cord. We next examined cellular uptake of IFNγ-DC-EVs by transfecting IFNγ-DC-EVs with mCherry mRNA prior to nasal administration. mCherry-positive cells were found along the rostrocaudal axis of the brain to the brainstem. These cells morphologically resembled oligodendrocytes, and indeed cell-specific co-staining for neurons, astrocytes, microglia and oligodendrocytes showed that mcherry positive cells were predominantly oligodendrocytes. This is in keeping with our prior in vitro results showing that IFNγ-DC-EVs are preferentially taken up by oligodendrocytes, and to a lesser extent, microglia. To confirm that IFNγ-DC-EVs delivered cargo to oligodendrocytes, we quantified protein levels of miR-219 mRNA targets expressed in oligodendrocyte lineage cells, and found significantly reduced expression. Finally, we compared intranasal versus intravenous delivery of Xenolight DiR-labelled IFNγ-DC-EVs. Though labelled IFNγ-DC-EVs entered the CNS via both routes, we found that nasal delivery more specifically targeted the CNS with less accumulation in the liver. Taken together, these data show that intranasal administration is an effective route for delivery of IFNγ-DC-EVs to the CNS, and provides additional support for their development as an EV-based neurotherapeutic that, for the first time, targets oligodendrocytes.

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Alteration of Interferon Gamma (IFN-γ) in Human Plasma with Graded Physical Activity

Cited by 18 publications

References 22 publications

The Mediating Effect of Different Exercise Programs on the Immune Profile of Frail Older Women with Cognitive Impairment

The Mediating Effect of Different Exercise Programs on the Immune Profile of Frail Older Women with Cognitive Impairment

Physical Exercise as a Multimodal Tool for COVID-19: Could It Be Used as a Preventive Strategy?

IFNγ-stimulated dendritic cell extracellular vesicles can be nasally administered to the brain and enter oligodendrocytes

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