“…Traditionally, this has been accomplished either through the overexpression of specific targets directly involved in the pathway (Chen et al, 2001;Irani et al, 1999) or alteration of the overall protein synthesis machinery, such as the expression of chaperone proteins (Borth et al, 2005;Davis et al, 2000;Higgins et al, 2003;Kitchin and Flickinger, 1995;Yokoyama et al, 2000) or transcriptional factors (Tigges and Fussenegger, 2006) involved in the secretory pathway. However, as illustrated in Figure 1A, a similar strategy can be implemented using RNA interference (RNAi) (Hebert et al, 2008).…”