Alteration of gut microbial profile in patients with diabetic nephropathy

Du, Xian; Liu, Jia; Yu, Xue; Kong, Xiangyun; Lv, Chen; Li, Ziqiang; Huang, Yühong; Wang, Baohe

doi:10.1007/s12020-021-02721-1

Cited by 52 publications

(66 citation statements)

References 41 publications

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“…Much of the published research for Actinomarinales (O) has taken place in aquatic environments, and they likely play a significant role in the global C cycle [96]. Gammaproteobacteria (C) R7C24 (O) was likely misclassified as there is no information available except for a finding in a diabetes medical trial [97]. Ultimately, the bacterial ASVs associated with SSS and tilled systems likely favor nutrient-poor environments and are oligotrophic.…”

Section: Discussionmentioning

confidence: 99%

Soil Microbial Indicators within Rotations and Tillage Systems

et al. 2021

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Recent advancements in agricultural metagenomics allow for characterizing microbial indicators of soil health brought on by changes in management decisions, which ultimately affect the soil environment. Field-scale studies investigating the microbial taxa from agricultural experiments are sparse, with none investigating the long-term effect of crop rotation and tillage on microbial indicator species. Therefore, our goal was to determine the effect of rotations (continuous corn, CCC; continuous soybean, SSS; and each phase of a corn-soybean rotation, Cs and Sc) and tillage (no-till, NT; and chisel tillage, T) on the soil microbial community composition following 20 years of management. We found that crop rotation and tillage influence the soil environment by altering key soil properties, such as pH and soil organic matter (SOM). Monoculture corn lowered pH compared to SSS (5.9 vs. 6.9, respectively) but increased SOM (5.4% vs. 4.6%, respectively). Bacterial indicator microbes were categorized into two groups: SOM dependent and acidophile vs. N adverse and neutrophile. Fungi preferred the CCC rotation, characterized by low pH. Archaeal indicators were mainly ammonia oxidizers with species occupying niches at contrasting pHs. Numerous indicator microbes are involved with N cycling due to the fertilizer-rich environment, prone to aquatic or gaseous losses.

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Section: Discussionmentioning

confidence: 99%

Soil Microbial Indicators within Rotations and Tillage Systems

et al. 2021

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“…The composition of gut microbiota in the faeces of the patients with stage 3 DKD was at the middle levels between healthy controls and patients with stage 4 [64]. The gender and body mass index had slight influence on the gut microbiota profile but the main difference still came from the disease [64]. The latest 16S ribosomal deoxyribonucleic acid gene sequencing analysis showed dysbiosis of gut microbial was demonstrated in patients with diabetic mellitus and DKD, and relative abundance of some short chain fatty acids-producing bacteria was lowered in patients with DKD [65].…”

Section: Iga Nephropathymentioning

confidence: 97%

“…Recently, the study showed that faecal microbial richness and diversity in patients with DKD were decreased compared with healthy controls [64]. The composition of gut microbiota in the faeces of the patients with stage 3 DKD was at the middle levels between healthy controls and patients with stage 4 [64]. The gender and body mass index had slight influence on the gut microbiota profile but the main difference still came from the disease [64].…”

Section: Iga Nephropathymentioning

confidence: 99%

“…Functional analysis revealed the dysregulation of lipopolysaccharide biosynthesis and carbohydrate metabolism in the gut microbiome of patients with DKD [63]. Recently, the study showed that faecal microbial richness and diversity in patients with DKD were decreased compared with healthy controls [64]. The composition of gut microbiota in the faeces of the patients with stage 3 DKD was at the middle levels between healthy controls and patients with stage 4 [64].…”

Section: Iga Nephropathymentioning

confidence: 99%

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Recent advances of gut microbiota in chronic kidney disease patients

Zhao

2022

Exploration of Medicine

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Chronic kidney disease (CKD) is a worldwide public health issue and has ultimately progressed to an end-stage renal disease that requires life-long dialysis or renal transplantation. However, the underlying molecular mechanism of these pathological development and progression remains to be fully understood. The human gut microbiota is made up of approximately 100 trillion microbial cells including anaerobic and aerobic species. In recent years, more and more evidence has indicated a clear association between dysbiosis of gut microbiota and CKD including immunoglobulin A (IgA) nephropathy, diabetic kidney disease, membranous nephropathy, chronic renal failure and end-stage renal disease. The current review describes gut microbial dysbiosis and metabolites in patients with CKD thus helping to understand human disease. Treatment with prebiotics, probiotics and natural products can attenuate CKD through improving dysbiosis of gut microbiota, indicating a novel intervention strategy in patients with CKD. This review also discusses therapeutic options, such as prebiotics, probiotics and natural products, for targeting dysbiosis of gut microbiota in patients to provide more specific concept-driven therapy strategy for CKD treatment.

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“…Specifically, the Escherichia-Shigella and Prevotella_9 genera could accurately distinguish DN patients from T2DM without renal disease patients, while the Prevotella_9 genus could accurately distinguish T2DM without renal disease patients from healthy controls. Moreover, patients with stage IV DN had a higher abundance of Haemophilus and Lachnospiraceae_UCG-004 compared with patients with stage III DN, indicating that the gut microbiota was involved in the progression of DN ( Du et al, 2021 ). Further research demonstrated that the dysregulated gut microbiota inhibited adenosine 5’-monophosphate-activated protein kinase α (AMPKα) by activating G protein-coupled receptor 43 (GPR43), which in turn led to insulin resistance-mediated podocyte and kidney damage ( Lu et al, 2021 ).…”

Section: Gut Microbiota and T2dmmentioning

confidence: 99%

Gut Microbiota: An Important Player in Type 2 Diabetes Mellitus

Zhou

Sun

et al. 2022

Front. Cell. Infect. Microbiol.

112

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Type 2 diabetes mellitus (T2DM) is one of the common metabolic diseases in the world. Due to the rise in morbidity and mortality, it has become a global health problem. To date, T2DM still cannot be cured, and its intervention measures mainly focus on glucose control as well as the prevention and treatment of related complications. Interestingly, the gut microbiota plays an important role in the development of metabolic diseases, especially T2DM. In this review, we introduce the characteristics of the gut microbiota in T2DM population, T2DM animal models, and diabetic complications. In addition, we describe the molecular mechanisms linking host and the gut microbiota in T2DM, including the host molecules that induce gut microbiota dysbiosis, immune and inflammatory responses, and gut microbial metabolites involved in pathogenesis. These findings suggest that we can treat T2DM and its complications by remodeling the gut microbiota through interventions such as drugs, probiotics, prebiotics, fecal microbiota transplantation (FMT) and diets.

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Alteration of gut microbial profile in patients with diabetic nephropathy

Cited by 52 publications

References 41 publications

Soil Microbial Indicators within Rotations and Tillage Systems

Soil Microbial Indicators within Rotations and Tillage Systems

Recent advances of gut microbiota in chronic kidney disease patients

Gut Microbiota: An Important Player in Type 2 Diabetes Mellitus

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