Alteration of erythrocyte membrane Na, K‐ATPase in children with borderline or essential hypertension

Stojadinovic, Nataša D.; Petronijević, Milan R.; Pavićević, M; Mršulja, B. B.; Kostić, Milena

doi:10.1002/cbf.652

Cited by 12 publications

(7 citation statements)

References 36 publications

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“…Several studies have shown that the activity of Na + , K + -ATPase is inhibited or decreased in hypertensive subjects. 24,25 Although inhibition of Na + , K + -ATPase could explain the decreased RBC Ki levels, it would be expected to be accompanied by increased RBC Nai levels which we did not observe in our study. The fact that RBC Nai is not increased in hypertensives is supported by several studies 26,9,10 and opposed by others.…”

Section: Discussioncontrasting

confidence: 65%

Red blood cell K+ could be a marker of K+ changes in other cells involved in blood pressure regulation

Delgado

Delgado-Almeida

2003

J Hum Hypertens

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The aim of this study is to determine whether red blood cell K + content (RBC Ki ) is associated with blood pressure levels and, if so, could RBC Ki be a marker of potassium changes in other cells involved in blood pressure regulation. The study was performed on 50 untreated hypertensives, 32 of their offspring and 50 age-and sex-matched controls. Systolic (SBP) and diastolic (DBP) blood pressures, height, weight, plasma, urine and red blood cell electrolytes were measured in all subjects. RBC Ki was significantly lower in hypertensives than in offspring of hypertensives and normotensive controls. Offspring of hypertensives had significantly lower RBC Ki than normotensive controls. Plasma K + was significantly lower both in hypertensives and offspring of hypertensives when compared to normotensive controls. A significant negative correlation was found in hypertensives between RBC Ki and DBP (r ¼ À0.27, P ¼ 0.04) and in offspring of hypertensives between RBC Ki and DBP (r ¼ À0.43, P ¼ 0.02). A significant correlation was found in hypertensives between RBC Ki and plasma K + (r ¼ 0.3, P ¼ 0.02). A positive correlation with borderline significance was found in hypertensives between RBC Ki and ionized Ca 2+ (r ¼ 0.2, P ¼ 0.1). In conclusion, our results support the hypothesis that RBC Ki is associated with blood pressure levels and that the measurement of RBC Ki levels may represent a biochemical marker for K + changes in other cells involved in blood pressure regulation. Further studies are necessary to explain the exact mechanisms of reduced RBC Ki levels in hypertensive patients and their offspring.

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Section: Discussioncontrasting

confidence: 65%

Red blood cell K+ could be a marker of K+ changes in other cells involved in blood pressure regulation

Delgado

Delgado-Almeida

2003

J Hum Hypertens

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“…In adult patients suffering from essential hypertension, an increased intracellular Na + concentration, lowered Na,K-ATPase activity together with higher peroxidation of lipids were documented in erythrocytes [ 22 , 23 , 24 , 25 ], and almost the same was shown in patients with prehypertension [ 26 ]. Similarly, in the samples from hypertensive children, the Na,K-ATPase enzyme was also significantly inhibited, as indicated by kinetic studies showing a decrease of V max value presumably due to alterations of the antioxidant status [ 27 ].…”

Section: Erythrocyte Nak-atpase and Deformability In Various Patho/physiological Situationsmentioning

confidence: 99%

Erythrocyte Deformability and Na,K-ATPase Activity in Various Pathophysiological Situations and Their Protection by Selected Nutritional Antioxidants in Humans

Radošinská

Vrbjar

2021

IJMS

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The physicochemical and functional properties of erythrocytes are worsened in a variety of diseases. Erythrocyte deformability refers to their ability to adjust their shape according to external forces exerted against them in the circulation. It is influenced by the functionality of the Na,K-ATPase enzyme, which is localized in their membranes. The proposed review is focused on knowledge regarding changes in erythrocyte Na,K-ATPase activity, and their impact on erythrocyte deformability in various pathophysiological situations observed exclusively in human studies, as well as on the potential erytroprotective effects of selected natural nutritional antioxidants. A clear link between the erythrocyte properties and the parameters of oxidative stress was observed. The undesirable consequences of oxidative stress on erythrocyte quality and hemorheology could be at least partially prevented by intake of diverse antioxidants occurring naturally in foodstuffs. Despite intensive research concerning the effect of antioxidants, only a small number of investigations on erythrocyte properties in humans is available in databases. It is worth shifting attention from animal and in vitro experiments and focusing more on antioxidant administration in human studies in order to establish what type of antioxidant, in what concentration, and in which individuals it may provide a beneficial effect on the human organism, by protecting erythrocyte properties.

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“…An increased free radical activity and alterations of antioxidant status have been previously reported in essential and pediatric hypertension, 5,41 in women with pregnancy-induced hypertension, 42 and in other cardiovascular diseases. 35,43 Conversely, Ceriello et al 6 reported that glutathione infusion lowered blood pressure in hypertensive but not in diabetic hyperglycemic subjects.…”

Section: Barbagallo Et Almentioning

confidence: 80%

Effects of Glutathione on Red Blood Cell Intracellular Magnesium

et al. 1999

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Abstract-Recent evidence suggests that the endogenous antioxidant glutathione may play a protective role in cardiovascular disease. To directly investigate the role of glutathione in the regulation of glucose metabolism in hypertension, we studied the acute effects of in vivo infusions of this antioxidant (alone or in combination with insulin) on whole body glucose disposal (WBGD) using euglycemic glucose clamp and the effects on total red blood cell intracellular magnesium (RBC-Mg) in hypertensive (nϭ20) and normotensive (nϭ30) subjects. The relationships among WBGD, circulating reduced/oxidized glutathione (GSH/GSSG) levels, and RBC-Mg in both groups were evaluated. The in vitro effects of glutathione (100 mol/L) on RBC free cytosolic magnesium (Mg i ) were also studied.

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Alteration of erythrocyte membrane Na, K‐ATPase in children with borderline or essential hypertension

Cited by 12 publications

References 36 publications

Red blood cell K+ could be a marker of K+ changes in other cells involved in blood pressure regulation

Red blood cell K+ could be a marker of K+ changes in other cells involved in blood pressure regulation

Erythrocyte Deformability and Na,K-ATPase Activity in Various Pathophysiological Situations and Their Protection by Selected Nutritional Antioxidants in Humans

Effects of Glutathione on Red Blood Cell Intracellular Magnesium

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