Alteration of cyclosporine (CsA)-induced nephrotoxicity by gamma linolenic acid (GLA) and eicosapentaenoic acid (EPA) in Wistar rats

Morphake, P.; Bariéty, J; Darlametsos, I.; Tsipas, G.; Gkikas, G.; Hornysh, A.; Papanikolaou, Nikolaos

doi:10.1016/0952-3278(94)90102-3

Cited by 18 publications

(5 citation statements)

References 22 publications

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“…This magnitude is comparable to the loss in body weight in the present study after 7 days. The reason of this loss is possibly related to anorexic effect of CsA and in agreement with previous studies in rats [39][40][41]. Weight loss can also be attributed to the higher metabolic rate in response to the catabolic action of CsA [42].…”

Section: Discussionsupporting

confidence: 91%

“…There was a significant decrease in body weight of CsA treated rats which began on day 7 of the study and onward. Morphake et al, [39] showed using CsA model in rats a decrease in creatinine clearance in addition to body weight loss by almost 13% within 7 days of CsA treatment. This magnitude is comparable to the loss in body weight in the present study after 7 days.…”

Section: Discussionmentioning

confidence: 99%

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Apocynin and catalase prevent hypertension and kidney injury in Cyclosporine A-induced nephrotoxicity in rats

et al. 2020

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Oxidative stress is involved in the pathogenesis of a number of diseases including hypertension and renal failure. There is enhanced expression of nicotinamide adenine dinucleotide (NADPH oxidase) and therefore production of hydrogen peroxide (H 2 O 2) during renal disease progression. This study investigated the effect of apocynin, an NADPH oxidase inhibitor and catalase, an H 2 O 2 scavenger on Cyclosporine A (CsA) nephrotoxicity in Wistar-Kyoto rats. Rats received CsA (25mg/kg/day via gavage) and were assigned to vehicle, apocynin (2.5mmol/L p.o.), catalase (10,000U/kg/day i.p.) or apocynin plus catalase for 14 days. Renal functional and hemodynamic parameters were measured every week, and kidneys were harvested at the end of the study for histological and NADPH oxidase 4 (NOX4) assessment. Oxidative stress markers and blood urea nitrogen (BUN) were measured. CsA rats had higher plasma malondialdehyde (by 340%) and BUN (by 125%), but lower superoxide dismutase and total antioxidant capacity (by 40%, all P<0.05) compared to control. CsA increased blood pressure (by 46mmHg) and decreased creatinine clearance (by 49%, all P<0.05). Treatment of CsA rats with apocynin, catalase, and their combination decreased blood pressure to near control values (all P<0.05). NOX4 mRNA activity was higher in the renal tissue of CsA rats by approximately 63% (P<0.05) compared to controls but was reduced in apocynin (by 64%), catalase (by 33%) and combined treatment with apocynin and catalase (by 84%) compared to untreated CsA rats. Treatment of CsA rats with apocynin, catalase, and their combination prevented hypertension and restored renal functional parameters and tissue Nox4 expression in this model. NADPH inhibition and H 2 O 2 scavenging is an important therapeutic strategy during CsA nephrotoxicity and hypertension.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Apocynin and catalase prevent hypertension and kidney injury in Cyclosporine A-induced nephrotoxicity in rats

et al. 2020

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“…On the other hand, after a significant renal parenchymal injury, BUN begins to rise (Erdem et al, 2000). It was reported that nephrotoxic effect of cyclosporine was partially inhibited when the animals fed with EPO containing 9% gamma linolenic acid or fish oil supplemented with 5.6% eicosapentaenoic acid (Morphake et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Evening Primrose (Oenothera biennis) on the Some Biochemical Parameters in Rats with Gentamicin Induced Nephrotoxicity

Medineli

Mert

Irak

et al. 2021

Turkish JAF Sci.Tech.

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In this study, it was aimed to investigate the effect of evening primrose oil (EPO) on some biochemical parameters on nephrotoxicity induced by gentamicin (GM) in rats. The rats used in the study were randomly divided into 4 groups each consisting of 8 rats. The control group, EPO group, GM group and GM+ EPO group. The blood samples were taken 24 hours after the 8-day trial and kidneys were removed and saved for histopathological and PGE2 analysis. The serum creatinine, BUN, calcitriol, Ca, Na, Cl, K and P analyzes were performed via autoanalyser. PGE2 analysis was performed in kidney tissue via ELISA. Histopathological examination of the kidney tissues was performed. The levels of creatinine, BUN and Cl were significantly decreased and PGE2 and Ca increased in GM + EPO compared to GM group. The changes in the biochemical parameters examined and the histopathological findings obtained, it can be said that the EPO weakens the nephrotoxic damage caused by GM and has the protective effects on the kidney.

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“…The combination of primrose oil and fish oil has been shown to have the following effects: inhibition of bone resorption (22), decrease in malignancy of mammary carcinomas of rats (23,24), favorable reduction of plasma cholesterol and TG levels in the nephrotic syndrome (25), modulation of the renal syndrome induced by cyclosporine (26), alleviation of gastric hemorrhage caused by aspirin (27), reduction of intrarenal calcification (28), amelioration of radiation damage to the skin (29), and amelioration of lung injury induced by endotoxin (30). Decreased ex vivo conversion from AA to T X B 2 was observed in human platelets after the administration of both GLA and EPA in spite of increased AA content of the platelets (31).…”

Section: Discussionmentioning

confidence: 99%

Dietary effect of a symmetrical triacylglycerol, 1,3‐biseicosapentaenoyl‐2‐γ‐linolenoyl glycerol, on fatty acid composition of guinea pigs

Ohba

Akahane

Wakabayashi

et al. 1997

Lipids

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The dietary effect of 1,3-biseicosapentaenoyl-2-gamma-linolenoyl glycerol (STG) on the fatty acid composition of guinea pigs was examined and compared with that of an eicosapentaenoic acid ethyl ester (EPA-E) and of a soybean oil (SBO) diet. In terms of content of plasma lipid, EPA-E had a greater hypolipidemic effect than STG. On the other hand, in terms of EPA incorporation, contents of EPA in liver lipid were almost the same in the STG and EPA-E groups. Considering that the amount of EPA administered in the EPA-E group was almost 1.5 times that of the STG group, EPA may be absorbed more effectively as the glycerol ester than as the ethyl ester in guinea pigs. In all the tissue lipids, the STG group had a higher unsaturation index (UI) than the EPA-E group even though there is a lower UI in the STG diet than the EPA-E diet. These results suggest that greater amounts of desaturase products as a whole were synthesized in the STG group than in the other two groups. The dihomo-gamma-linolenic acid/arachidonic acid (DGLA/AA) ratio in plasma total lipids in the STG group was 3.5 times that of SBO group, and the DGLA/AA ratio in the EPA-E group was half that of the SBO group. In liver lipid, the ratios of DGLA/AA and EPA/AA in the STG group were 0.687 and 0.488 (phosphatidylcholine fraction) and 0.237 and 0.752 (phosphatidylethanolamine fraction), respectively. The ratio of DGLA/AA as well as the high EPA/AA ratio obtained in the present study with the STG diet may lead to physiological alterations, including enhanced synthesis of 1- and 3-series eicosanoids.

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Alteration of cyclosporine (CsA)-induced nephrotoxicity by gamma linolenic acid (GLA) and eicosapentaenoic acid (EPA) in Wistar rats

Cited by 18 publications

References 22 publications

Apocynin and catalase prevent hypertension and kidney injury in Cyclosporine A-induced nephrotoxicity in rats

Apocynin and catalase prevent hypertension and kidney injury in Cyclosporine A-induced nephrotoxicity in rats

The Effect of Evening Primrose (Oenothera biennis) on the Some Biochemical Parameters in Rats with Gentamicin Induced Nephrotoxicity

Dietary effect of a symmetrical triacylglycerol, 1,3‐biseicosapentaenoyl‐2‐γ‐linolenoyl glycerol, on fatty acid composition of guinea pigs

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