Alteration of choroidal vascular structure in diabetic macular edema

Quantitative Assessment of Choroidal Parameters in Patients with Various Types of Diabetic Macular Oedema: A Single-Centre Cross-Sectional Analysis

“…In our present study, the LA values in the cystoid DME group were lower than in the controls, whereas the eyes with diffuse DME and DME with subretinal fluid had higher SA values than the control eyes. The CVI values did not differ significantly according to the DME type, which is in line with the results reported by Gupta et al [ 34 ] and Kase et al [ 35 ]. While we found between-group differences in LA, SA, and TCA values for eyes with various DME types, none of them had a significant effect on CVI.…”

“…Similar to our present study, those researchers also observed choroidal thinning over the entire posterior pole [ 16 ]. However, some authors have reported an increase in choroidal thickness during DME [ 15 , 25 , 34 , 35 , 42 ], while others have found no significant association between the choroidal thickness and DME [ 18 , 24 , 26 , 43 ].…”

“…Still, little is known about the association between choroidal parameters and the type of DME [ 27 , 34 , 35 ]. Our present study did not show significant differences in the choroidal thickness and volume in eyes with various DME types.…”

“…Hence, CVI can be considered a relatively stable parameter to evaluate changes in the choroidal vasculature [ 33 ]. Unlike the relationship between choroidal thickness and DME, which has been the subject of many previous studies [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ], only a few authors have analysed choroidal thickness depending on DME type [ 27 , 34 , 35 ] and even fewer have studied CVI in various DME types [ 34 , 35 ].…”

Indicators of Visual Prognosis in Diabetic Macular Oedema

“…On the contrary, other investigators have suggested that choroidal blood volume, flow and velocity decreases in diabetic eyes with DMO, which may lead to hypoxia of the outer retina, thereby leading to increase in VEGF levels [ 90 , 91 , 92 ]. The choroid in DMO is also not affected by systemic factors such as increased HbA1c, blood pressure, cholesterol or abnormal renal function [ 93 ]. At the present time, there is insufficient evidence to suggest that changes in central choroidal thickness, subfoveal choroidal thickness or choroidal vascularity index influence visual outcome in DMO [ 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 ].…”