Alteration of biochemical parameters related with exposure to lead in heavy alcohol drinkers

López, Clara; Vallejo, Norma E.; Piñeiro, Adriana; Uicich, Raúl; Damin, Carlos Fabián; Sarchi, María Inés; Lepori, Edda C. Villaamil; Roses, Otmaro Enrique

doi:10.1006/phrs.2001.0899

Cited by 6 publications

(2 citation statements)

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“…Inter-individual variation in blood Pb level is affected by various lifestyle and behavioral factors (i.e., smoking, drinking, dietary intake, and physical activity), as well as exposure dose [ 7 , 9 , 12 – 14 ]. In addition, genetic differences related to Pb toxicokinetics and toxicodynamics influence the body burden and toxic effects of this metal [ 13 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Exome-wide association study identifies genetic polymorphisms of C12orf51, MYL2, and ALDH2 associated with blood lead levels in the general Korean population

et al. 2017

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BackgroundLead (Pb) is a ubiquitous toxic metal present in the environment that poses adverse health effects to humans. Inter-individual variation in blood Pb levels is affected by various factors, including genetic makeup. However, limited data are available on the association between genetic variation and blood Pb levels. The purpose of this study was to identify the genetic markers associated with blood Pb levels in the Korean population.MethodsThe study subjects consisted of 1,483 healthy adults with no history of occupational exposure to Pb. We measured blood Pb levels and calculated probable daily intake of Pb according to dietary data collected using 24-hour recall. We conducted exome-wide association screening using Illumina Human Exome-12v1.2 platform (n = 500) and a replication analysis using VeraCode Goldengate assay (n = 1,483).ResultsAmong the 244,770 single nucleotide polymorphisms (SNPs) tested, 12 SNPs associated with blood Pb level were identified, with suggestive significance level (P < 1 × 10−4). In the Goldengate assay for replication, three SNPs (C12orf51 rs11066280, MYL2 rs12229654, and ALDH2 rs671) were associated with statistically suggestively significant differences in blood Pb levels. When stratified by drinking status, a potential association of C12orf51 rs11066280, MYL2 rs12229654, and ALDH2 rs671 with blood Pb level was observed only in drinkers. A marginally significant gene-environment interaction between ALDH2 rs671 and alcohol consumption was observed in relation to blood Pb levels. The effects of the three suggestively significant SNPs on blood Pb levels was dependent on daily calcium intake amounts.ConclusionsThis exome-wide association study indicated that C12orf51 rs11066280, MYL2 rs12229654, and ALDH2 rs671 polymorphisms are linked to blood Pb levels in the Korean population. Our results suggest that these three SNPs are involved in the determination of Pb levels in Koreans via the regulation of alcohol drinking behavior, and that their negative effects may be compensated by appropriate calcium intake.Electronic supplementary materialThe online version of this article (doi:10.1186/s12940-017-0220-x) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Exome-wide association study identifies genetic polymorphisms of C12orf51, MYL2, and ALDH2 associated with blood lead levels in the general Korean population

et al. 2017

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“…Lead concentration in wines deserves special consideration because of its toxicity and cumulative character. Consumption of alcoholic beverages, especially wines, can infl uence the concentration of Pb in blood (7)(8)(9)(10). Long-term consumption of wine with high Pb levels could lead to chronic poisoning.…”

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confidence: 99%

Determination of Lead in Croatian Wines by Graphite Furnace Atomic Absorption Spectrometry

Tariba

Pizent²,

Kljaković-Gašpić³

2011

Archives of Industrial Hygiene and Toxicology

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A method has been developed for direct determination of lead in wine by graphite furnace atomic absorption spectrometry (GFAAS) with Zeeman-effect background correction. The thermal behaviour of Pb during pyrolysis and atomisation stages was investigated without matrix modifi er and in the presence of Pd(NO 3 ) 2 , Pd(NO 3 ) 2 + Mg(NO 3 ) 2 x 6H 2 O, and NH 4 H 2 PO 4 + Mg(NO 3 ) 2 x 6H 2 O as matrix modifi ers. A simple 1:1 dilution of wine samples with Pd(NO 3 ) 2 as a matrix modifi er proved optimal for accurate determination of Pb in wine. Mean recoveries were 106 % for red and 114 % for white wine, and the detection limit was 3 μg L -1 . Within-run precision of measurements for red and white wine was 2.1 % and 1.8 %, respectively. in home-made wines. There were no statistically signifi cant differences (P<0.05) in Pb concentration between commercial and home-made wines or between red and white wines.

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Occupational and Environmental Hepatotoxicity

Schiano¹,

Hunt²

2006

Zakim and Boyer's Hepatology

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Alteration of biochemical parameters related with exposure to lead in heavy alcohol drinkers

Cited by 6 publications

References 16 publications

Exome-wide association study identifies genetic polymorphisms of C12orf51, MYL2, and ALDH2 associated with blood lead levels in the general Korean population

Exome-wide association study identifies genetic polymorphisms of C12orf51, MYL2, and ALDH2 associated with blood lead levels in the general Korean population

Determination of Lead in Croatian Wines by Graphite Furnace Atomic Absorption Spectrometry

Occupational and Environmental Hepatotoxicity

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