Alteration in the liver metabolome of rats with metabolic syndrome after treatment with Hydroxytyrosol. A Mass Spectrometry And Nuclear Magnetic Resonance - based metabolomics study

Dagla, Ioanna; Benaki, Dimitra; Baira, Eirini; Lemonakis, Nikolaos; Poudyal, Hemant; Brown, Lindsay; Tsarbopoulos, Anthony; Skaltsounis, Alexios‐Léandros; Mikros, Emmanuel; Gikas, Evagelos

doi:10.1016/j.talanta.2017.09.029

Cited by 16 publications

(11 citation statements)

References 44 publications

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“…HTyr inhibits lipogenesis, both de novo fatty acids and cholesterol syntheses without an effect on cell viability and the metabolism of linoleic acid, retinol, sphingolipids and arachidonic acid, whereas glycerolipid metabolism is upregulated [77]. It was shown that HTyr has beneficial effect in hyperlipidemia as it modifies genes related with adipocyte maturation and differentiation and inhibits lipid formation [78]. HTyr was shown to be effective towards the mobilization of lipids [79].…”

Section: Hydroxytyrosolmentioning

confidence: 99%

Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health

et al. 2019

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The Mediterranean diet and olive oil as its quintessential part are almost synonymous with a healthy way of eating and living nowadays. This kind of diet has been highly appreciated and is widely recognized for being associated with many favorable effects, such as reduced incidence of different chronic diseases and prolonged longevity. Although olive oil polyphenols present a minor fraction in the composition of olive oil, they seem to be of great importance when it comes to the health benefits, and interest in their biological and potential therapeutic effects is huge. There is a growing body of in vitro and in vivo studies, as well as intervention-based clinical trials, revealing new aspects of already known and many new, previously unknown activities and health effects of these compounds. This review summarizes recent findings regarding biological activities, metabolism and bioavailability of the major olive oil phenolic compounds—hydroxytyrosol, tyrosol, oleuropein, oleocanthal and oleacein—the most important being their antiatherogenic, cardioprotective, anticancer, neuroprotective and endocrine effects. The evidence presented in the review concludes that these phenolic compounds have great pharmacological potential, however, further studies are still required.

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Section: Hydroxytyrosolmentioning

confidence: 99%

Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health

et al. 2019

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“…OO polyphenols also showed protective effects on in vitro models of obesity. Indeed, HT inhibited lipogenesis [99] and regulated genes related to adipocyte maturation and differentiation [100,101]. Similarly, Tyr downregulated lipid synthesis in primary-cultured rat-hepatocytes [102] and also exerted beneficial effects in NAFLD, increasing hepatic cystathionine β-synthase and cystathionine γ-lyase expression and hydrogen sulphide synthesis in high-fat diet-fed mice [103].…”

Section: Unsaponifiable Fractionmentioning

confidence: 99%

The Nutraceutical Value of Olive Oil and Its Bioactive Constituents on the Cardiovascular System. Focusing on Main Strategies to Slow Down Its Quality Decay during Production and Storage

et al. 2019

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Cardiovascular diseases represent the principal cause of morbidity and mortality worldwide. It is well-known that oxidative stress and inflammatory processes are strongly implicated in their pathogenesis; therefore, anti-oxidant and anti-inflammatory agents can represent effective tools. In recent years a large number of scientific reports have pointed out the nutraceutical and nutritional value of extra virgin olive oils (EVOO), strongholds of the Mediterranean diet, endowed with a high nutritional quality and defined as functional foods. In regard to EVOO, it is a food composed of a major saponifiable fraction, represented by oleic acid, and a minor unsaponifiable fraction, including a high number of vitamins, polyphenols, and squalene. Several reports suggest that the beneficial effects of EVOO are linked to the minor components, but recently, further studies have shed light on the health effects of the fatty fraction and the other constituents of the unsaponifiable fraction. In the first part of this review, an analysis of the clinical and preclinical evidence of the cardiovascular beneficial effects of each constituent is carried out. The second part of this review is dedicated to the main operating conditions during production and/or storage that can directly influence the shelf life of olive oil in terms of both nutraceutical properties and sensory quality.

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“…In Wistar rats, both HT- and in particular secoiridoid-supplemented diets (5 mg/kg/day) modulated the aorta and heart proteome compared to the standard diet, downregulating proteins related to proliferation and migration of endothelial cells and occlusion of blood vessels in the former and proteins related to heart failure in the latter [ 88 ]. In another study in rats, a high-carbohydrate high-fat diet (MS-inducing diet) + HT (20 mg/kg/day) was effective towards the mobilization of lipids as compared to only an MS-inducing diet, with branched fatty acid esters of hydroxy oleic acids lipids being regulated in the HT-supplemented group, denoting the alleviation of MS [ 89 ]. With regard to research in humans, clinical trial-derived evidence where a diet supplemented with phenol-rich olive oils or phenolic extracts is administered is increasing ( Table 1 , Figure 1 ).…”

Section: Cardiovascular Disease Metabolic Syndrome Type 2 Diabetmentioning

confidence: 99%

Pharma-Nutritional Properties of Olive Oil Phenols. Transfer of New Findings to Human Nutrition

Crespo

Tomé‐Carneiro

Dávalos

et al. 2018

Foods

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The Mediterranean diet has been long associated with improved cardiovascular prognosis, chemoprevention, and lower incidence of neurodegeneration. Of the multiple components of this diet, olive oil stands out because its use has historically been limited to the Mediterranean basin. The health benefits of olive oil and some of its components are being rapidly decoded. In this paper we review the most recent pharma-nutritional investigations on olive oil biophenols and their health effects, chiefly focusing on recent findings that elucidate their molecular mechanisms of action.

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Alteration in the liver metabolome of rats with metabolic syndrome after treatment with Hydroxytyrosol. A Mass Spectrometry And Nuclear Magnetic Resonance - based metabolomics study

Cited by 16 publications

References 44 publications

Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health

Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health

The Nutraceutical Value of Olive Oil and Its Bioactive Constituents on the Cardiovascular System. Focusing on Main Strategies to Slow Down Its Quality Decay during Production and Storage

Pharma-Nutritional Properties of Olive Oil Phenols. Transfer of New Findings to Human Nutrition

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