Alteration in serum klotho levels in anorexia nervosa patients

Wolf, Ido; Stein, Dan J.; Shahmoon, Shiri; Ziv, Shimrit Ilana; Hemi, Rina; Kanety, Hannah; Rubinek, Tami; Modan‐Moses, Dalit

doi:10.1016/j.clnu.2015.07.013

Cited by 10 publications

(5 citation statements)

References 36 publications

(54 reference statements)

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“…It cannot be excluded that genetic polymorphisms of the Klotho gene also contribute to such physical states [ 62 , 63 ], even in relatively young and healthy individuals [ 58 ]. Gender and BMI were not significant modifiers in our study, which has also been demonstrated in several human studies [ 8 , 64 ], as well as animal studies [ 65 ]. Further large-scale prospective studies are required to verify our findings in different groups of healthy individuals.…”

Section: Discussionsupporting

confidence: 89%

Association between Serum Soluble α-Klotho and Urinary Albumin Excretion in Middle-Aged and Older US Adults: NHANES 2007–2016

Chang

Zheng

et al. 2023

JCM

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(1) Background: Preclinical and clinical studies on the anti-aging effect of α-Klotho are emerging. Urinary albumin excretion (UAE) is a well-known biomarker of kidney injury and generalized damage in the cardiovascular system. However, the potential relationship between α-Klotho and UAE is limited and controversial. This study aimed to quantify this relationship in the general middle-aged and elderly population from the National Health and Nutrition Survey (NHANES) 2007–2016. (2) Methods: Serum α-Klotho was measured by enzyme-linked immunosorbent assay. UAE was assessed by the albumin-to-creatinine ratio (ACR). After adjusting for several confounding variables, the relationship between α-Klotho and ACR was analyzed by weighted multivariable logistic regression, subgroup analysis, and interaction tests. A generalized additive model (GAM) with smooth functions using the two-piecewise linear regression model was used to examine the potential nonlinear relationship between α-Klotho and ACR. (3) Results: Among 13,584 participants aged 40–79 years, we observed an independent and significant negative correlation between α-Klotho and ACR (β = −12.22; 95% CI, −23.91, −0.53, p = 0.0448) by multivariable logistic regression analysis, especially in those with age ≥ 60 years, pulse pressure (PP) ≥ 60 mmHg, hypertension or diabetes. We further discovered the nonlinear relationship between α-Klotho and ACR by GAM, revealing the first negative and then positive correlations with an inflection point of 9.91 pg/mL between α-Klotho and ACR. (4) Conclusions: A dose-response relationship between α-Klotho and ACR was demonstrated, and the negative correlation therein indicated that α-Klotho has potential as a serum marker and prophylactic or therapeutic agent despite its metabolic and effective mechanisms needing to be further explored.

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Section: Discussionsupporting

confidence: 89%

Association between Serum Soluble α-Klotho and Urinary Albumin Excretion in Middle-Aged and Older US Adults: NHANES 2007–2016

Chang

Zheng

et al. 2023

JCM

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“…However, other studies suggest a close relationship between Klotho levels and body weight, especially in patients with obesity or anorexia nervosa. 31,32 Some possible hypotheses to explain such contrasting results could be: (i) the local administration in the CNS in our study, rather than systemic intravenous administration, (ii) 6 months of klotho overexpression is not enough time to observe general physical effects; and/or (iii) the vector dose injected is not sufficient to increase Klotho levels in plasma up to concentrations affecting the skeletal muscle.…”

Section: Discussionmentioning

confidence: 73%

Secreted αKlotho isoform protects against age-dependent memory deficits

et al. 2017

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αKlotho is a gene regulator of aging, increasing life expectancy when overexpressed and accelerating the development of aging phenotypes when inhibited. In mice, expression levels of the secreted isoform Klotho (s-KL) are very high in the brain, suggesting that s-KL activity may have an important role in the nervous system. Here we study the functional relevance at behavioural level of modifying s-KL levels in the aging brain. We used AAVrh10 vectors to deliver and sustained expression of s-KL in 6-and 12-monthold wild-type C57BL/6J males. This study demonstrates for we believe the first time in vivo that 6 months after a single injection of s-KL into the central nervous system, long-lasting and quantifiable enhancement of learning and memory capabilities are found. More importantly, cognitive improvement is also observable in 18-month-old mice treated once, at 12 months of age. These findings demonstrate the therapeutic potential of s-KL as a treatment for cognitive decline associated with aging.

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“…Lastly, though this paper is limited by a definition of bone disease that is very broad, future studies should assess the relationship between iron status and bone health as both iron deficiency and iron overload are currently being studied as factors that may impact bone health [43][44][45][46][47][48][49][50]. It is likely that the broad definition of bone disease and small number of assessments of bone health underestimated correlations between bone health and iron dynamics in this cohort.…”

Section: Discussionmentioning

confidence: 99%

Anemia of Inflammation in Patients with Intestinal Failure on Home Parenteral Nutrition

Namjoshi¹,

Farkas

Jackson

et al. 2020

SN Compr. Clin. Med.

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Anemia is common in intestinal failure (IF), but it is unknown if anemia in IF is due to iron deficiency or another etiology. Understanding iron status is important, as deficiency and overload are both associated with multisystem morbidity and mortality. The objective was to determine the etiology of anemia in a cohort of patients with IF and characterize iron status with respect to multisystem outcomes. This was a single center retrospective cohort analysis of iron parameters from August 1998 to March 2018 in 54 IF patients (355 person years). Thirty-eight percent of measurements showed iron deficiency, 36% anemia of inflammation, 21% indeterminate iron status, and 5% suggested iron overload. Mean direct and total bilirubin were elevated when ferritin was > 200 ng/mL and in inflamed and overloaded patients compared with iron-deficient patients. For every 10% increase in Tsat, bilirubin increased by 0.58 mg/dL from baseline (p = 0.003). Tsat > 50% had a mean positive culture probability of 60%. The probability of renal disease increased over time and average GFR decreased over time (−3.14 ± 1.37 mL/min per 1.73 m 2), and nearly one in five patients in this study had chronic kidney disease (CKD). Patients with IF are at risk for both iron deficiency anemia as well as anemia of inflammation, with at a portion of patients with anemia of inflammation and overload having elevated risk of cholestasis, CKD, and infection compared to their peers. Careful assessment of inflammation, risk of infection, and renal function should be performed prior to dosing iron to ensure safe and effective delivery of this essential micronutrient. Future directions include determination of extra-renal sources of inflammation in IF.

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Alteration in serum klotho levels in anorexia nervosa patients

Cited by 10 publications

References 36 publications

Association between Serum Soluble α-Klotho and Urinary Albumin Excretion in Middle-Aged and Older US Adults: NHANES 2007–2016

Association between Serum Soluble α-Klotho and Urinary Albumin Excretion in Middle-Aged and Older US Adults: NHANES 2007–2016

Secreted αKlotho isoform protects against age-dependent memory deficits

Anemia of Inflammation in Patients with Intestinal Failure on Home Parenteral Nutrition

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