Alteration in Salivary Function in Early HIV Infection

Lin, Alan; Johnson, D. A.; Stephan, Kevin; Yeh, Chih Ko

doi:10.1177/154405910308200912

Cited by 46 publications

(43 citation statements)

References 16 publications

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“…Notre analyse n'a pas montré de relation entre le taux de lymphocytes CD4 et la diminution du débit salivaire non stimulé. Lin et al [4] ont étudié les effets de l'infection à VIH ou stade précoce (CD4 > 200 cellules.mm −3 ) sur la fonction des glandes salivaires et la relation de ce dysfonctionnement avec la prise de médicaments sialoprives. Ils ont trouvé une diminution du débit salivaire non stimulé et stimulé au cours des premiers stades de l'infection.…”

Section: Fig 2 Subdivision Of Patients On Arv According To the Typeunclassified

“…La prévalence de l'hypofonctionnement des glandes salivaires et de la xérostomie a été retrouvée chez 2 % à 10 % des patients vivant avec le VIH (PVVIH) [1][2][3]. De nombreuses études ont rapporté une altération de la fonction des glandes salivaires et de la composition de la salive chez les PVVIH, aux stades précoce et avancé de l'infection [4,5]. Depuis quelques années, les antirétroviraux (ARV) représentent la stratégie thé-rapeutique majeure pour lutter contre l'infection au VIH.…”

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Évaluation du débit salivaire chez les personnes vivant avec le VIH sous traitement antirétroviral

Lecor

Diop

Sall

et al. 2011

Med Buccale Chir Buccale

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(Reçu le 1er avril 2011, accepté le 16 mai 2011)Mots clés : débit salivaire / hyposalivation / VIH / traitement ARV Résumé -Introduction : L'altération de la fonction sécrétoire des glandes salivaires a souvent été associée au virus de l'immunodéficience humaine (VIH). Ces dernières années, la multithérapie associant différents antirétroviraux (ARV) est devenue la modalité de gestion de choix pour la prise en charge de l'infection à VIH. L'objectif de cette étude était d'évaluer l'effet des médicaments antirétroviraux sur la sécrétion salivaire chez des patients vivant avec le VIH. Matériel et méthodes : Une étude transversale comparative a été réalisée sur 166 patients vivant avec le VIH (dont 94 sous ARV et 72 ARV naïfs) à la clinique des Maladies infectieuses et tropicales, au CHUN de Fann (Dakar). Le débit salivaire non stimulé et le pH salivaire ont été évalués dans les deux groupes de patients. Les données ont été statistiquement analysées et exploitées en utilisant le logiciel SPSS. Résultats : Le profil sérologique des patients était largement dominé par le VIH-1 avec 87,1 %. Dans la population de patients vivant avec le VIH et sous ARV, 7,4 % présentaient une xérostomie et 5,3 % avaient une hyposialie et seule l'association thérapeutique TDF+3TC+NVP (Ténofovir + Lamivudine + Névirapine) était statistiquement associée à l'hyposialie. Par ailleurs, dans la population de patients vivant avec le VIH ARV naïfs, 20,8 % présentaient une xéro-stomie et 13,9 % une hyposialie ; le taux de lymphocytes T CD4 n'était pas corrélé à l'hyposialie. Conclusion : La fonction des glandes salivaires était beaucoup plus affectée chez les patients non traités ; est-ce à dire que le traitement ARV agit positivement sur la fonction sécrétoire des glandes salivaires ? D'autres études plus fines et sur des cohortes plus importantes devraient être envisagées pour confirmer cette tendance. Key words: salivary flow rate / hyposalivation / HIV / ARV treatmentAbstract -Assessment of salivary flow in people living with HIV receiving antiretroviral therapy. Introduction: Impaired salivary gland secretory function has often been associated with immunodeficiency virus (HIV). In last years, HAART (highly active antiretroviral therapy) has become the modality of choice for managing HIV infection. The objective of this study was to evaluate the effect of antiretroviral (ARV) drugs on salivary secretion in patients with HIV. Material and methods: A comparative cross-sectional study was performed on 166 patients living with HIV (including 94 on ART and 72 ART naive) of the Clinical Infectious and of Tropical Diseases of the CHUN Fann (Dakar). Unstimulated salivary flow rate and salivary pH were evaluated in the two groups of patient. The data were statistically analyzed using the SPSS Results: The serological profile of patients was largely dominated by HIV-1 (87.1%). 7.4% of patients living with HIV on ART, had xerostomia, and 5.3% had oligoptyalism and only the combination therapy TDF +3 TC + NVP (Tenofovir + Lamivudine + Nevirapine) was sta...

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Section: Fig 2 Subdivision Of Patients On Arv According To the Typeunclassified

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Évaluation du débit salivaire chez les personnes vivant avec le VIH sous traitement antirétroviral

Lecor

Diop

Sall

et al. 2011

Med Buccale Chir Buccale

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“…Dentre as manifestações bucais presentes em indivíduos HIV positivos, a xerostomia aparece como uma das mais frequentes, podendo levar a uma redução na qualidade de vida dessa população. O papel da saliva é de grande importância na manutenção da saúde da cavidade bucal 8 . Há uma estimativa de que 5% dos pacientes HIV positivos desenvolveram aumento bilateral das glândulas salivares, enquanto 10% a 30% apresentaram xerostomia, sendo esta um importante fator de contribuição para o aumento da incidência de cárie dentária em indivíduos infectados pelo HIV.…”

Section: Introductionunclassified

“…Tanto a xerostomia como a hipofunção da glândula salivar têm sido frequentemente associadas ao HIV, porém não há dados conclusivos 8,9 . Buscando contribuir para o esclarecimento desse tema, o presente estudo teve por objetivo revisar sistematicamente a associação entre xerostomia e a infecção pelo HIV/AIDS.…”

Section: Introductionunclassified

Xerostomia related to HIV infection /AIDS: a critical review

Tinós

Sales-Peres

2014

Rev. odontol. UNESP

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ResumoIntrodução: A presença de manifestações bucais em indivíduos HIV positivos é bastante comum, sendo que a xerostomia aparece como um dos problemas mais frequentes, podendo levar a uma redução na qualidade de vida dessa população. Objetivo: Este estudo objetivou realizar uma revisão crítica sobre a relação entre xerostomia e a infecção pelo HIV, a fim de despertar a atenção do cirurgião-dentista quanto à importância da atenção odontológica dirigida a esses pacientes. Material e método: Foram incluídos artigos publicados no período entre 2000 e 2009, indexados na base de dados PUBMED. Os descritores utilizados foram HIV e xerostomia, sendo adotados como critérios de exclusão: a ausência dos referidos descritores associados, a não localização do texto completo, os artigos baseados em estudos de caso ou série de casos, e a ausência do resumo na base de dados. Resultado: Com base nos estudos incluídos na revisão, pode-se afirmar que a xerostomia é uma manifestação comum da infecção pelo HIV, predispondo o paciente a vários outros problemas bucais. Dentre os fatores de risco para a sua ocorrência, foram relacionados: as baixas contagens de células T CD4+, a alta carga viral plasmática, o uso de alguns medicamentos e a terapia antirretroviral. Conclusão: A infecção pelo HIV/AIDS pode alterar as glândulas salivares. Além disso, importantes fatores de risco foram considerados para ocorrência de xerostomia: a presença da didanosina e da classe de medicamentos que corresponde aos inibidores de protease na terapia antirretroviral.Descritores: AIDS; HIV; saliva; terapia antirretroviral de alta atividade; xerostomia. Abstract Introduction:The presence of oral manifestations in HIV positive individuals is quite common. Xerostomia appears as one of the most frequent problems and may lead to a reduction in the quality of life of this population. Objective: This study was a critical review of the relationship between xerostomia and HIV infection, to attract the attention of dentists on the importance of dental care to these patients. Material and method: We included articles published between 2000 and 2009, indexed in PUBMED database. The descriptors used were "HIV" and "xerostomia", the exclusion criteria adopted were: the absence of these descriptors associated, non-location of the full-text, articles based on case studies or case series and the absence of the abstract in the database. Result: Based on studies in the review, it can be said that the xerostomia is a common manifestation of HIV infection, predisposing the patient to several other oral problems. Among the risk factors for its occurrence it was reported: low counts of CD4+ T cells, high plasma viral load, the use of some medications and antiretroviral therapy. Conclusion: The HIV/ AIDS can change the salivary glands, and were considered important risk factors for the occurrence of xerostomia the presence of didanosine and the drug class which corresponds to protease inhibitors in antiretroviral therapy.

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“…account for significant morbidity during the progression of HIV disease (Lin et al, 2003). Typically, HIV-SGD presents a unilateral or bilateral diffuse soft swelling resulting in facial disfigurement, and may be associated with pain.…”

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confidence: 99%

Viruses and Salivary Gland Disease (SGD)

Jeffers

Webster-Cyriaque

2011

Adv Dent Res.

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Viral infections are often associated with salivary gland pathology. Here we review the pathogenesis of HIV-associated salivary gland disease (HIV-SGD), a hallmark of diffuse infiltrative lymphocytosis syndrome. We investigate the presence and contributions of viral diseases to the pathogenesis of salivary gland diseases, particularly HIV-SGD. We have detected BK viral shedding in the saliva of HIV-SGD patients consistent with viral infection and replication, suggesting a role for oral transmission. For further investigation of BKV pathogenesis in salivary glands, an in vitro model of BKV infection is described. Submandibular (HSG) and parotid (HSY) gland salivary cell lines were capable of permissive BKV infection, as determined by BKV gene expression and replication. Analysis of these data collectively suggests the potential for a BKV oral route of transmission and salivary gland pathogenesis within HIV-SGD.

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Alteration in Salivary Function in Early HIV Infection

Cited by 46 publications

References 16 publications

Évaluation du débit salivaire chez les personnes vivant avec le VIH sous traitement antirétroviral

Évaluation du débit salivaire chez les personnes vivant avec le VIH sous traitement antirétroviral

Xerostomia related to HIV infection /AIDS: a critical review

Viruses and Salivary Gland Disease (SGD)

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