Alteration in plasma lipid profile in oral submucous fibrosis patients: A case control study

Kumar, Pramod; Singh, Amit; Sankhla, Bharat; Naraniya, Anjali

doi:10.4103/2278-330x.114134

Cited by 8 publications

(8 citation statements)

References 14 publications

(17 reference statements)

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“…Similarly, Gupta and Gupta [13] observed a significant decrease in plasma total cholesterol, HDL, TC, and TGL in the patients with precancerous lesions and conditions, Singh et al [14], reported a significant decrease in TC, HDLC and TGL in the oral cancer group. Kumar et al [15] and Kanthem and Guttikonda [16] found significantly decreased lipid levels in OSMF patients, Neerupakam et al [17] noted a significant decrease in the total cholesterol and HDL in oral cancer subjects, which was similar to the results of our study.…”

Section: Discussionsupporting

confidence: 91%

Alteration in Serum Lipid Profile Pattern in Oral Squamous Cell Carcinoma and Potentially Malignant Disorders

Agrawal

Nagarajappa

Bandela

et al. 2021

Pesqui. Bras. Odontopediatria Clín. Integr.

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To evaluate and compare lipid profile level in oral submucous fibrosis (OSMF), oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC) patients. Material and Methods: Thirty histopathologically diagnosed subjects each of OL, OSMF, OSCC were recruited along with 30 healthy controls. 5ml of venous blood is collected and estimated using standard diagnostic kits. Results: The mean of Total cholesterol level in controls was 219.03 mg%, in OSCC, OL and OSMF was 142.89 ± 10.21mg%, 155.44 ± 17.63 mg% and 180.60 ± 13.25 mg%, respectively. The mean low-density lipid level in controls was 137.24 mg and in OSCC, OL and OSMF groups were 109.28 ± 2.16 mg%, 126.63 ± 0.85 mg% and 119.15 ± 0.93 mg%, respectively. The mean of high-density lipid level in controls, OSCC, OL and OSMF was 42.87 ± 0.42 mg%, 36.50 ± 2.31 mg%, 21.13 ± 0.77 mg% and 28.37 ± 1.11mg%, respectively. The mean of very low density lipids level in controls, OSCC, OL and OSMF was 30.12 ± 1.51 mg%, 17.24 ± 0.80 mg%, 22.25 ± 0.93 mg% and 25.89 ± 0.43 mg%, respectively. The mean triglyceride level in controls, OSCC, OL and OSMF was 118.80 ± 9.47 mg%, 91.2 ± 3.03 mg%, 105.05 ± 2.96 mg% and 106.19 ± 3.09 mg%, respectively. Conclusion: Lipid profile levels could be early indicators of precancer and cancer.

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Section: Discussionsupporting

confidence: 91%

Alteration in Serum Lipid Profile Pattern in Oral Squamous Cell Carcinoma and Potentially Malignant Disorders

Agrawal

Nagarajappa

Bandela

et al. 2021

Pesqui. Bras. Odontopediatria Clín. Integr.

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“…Our study results coincided with the studies done by Kumar et al .,[ 15 ] in which they showed a significant decrease in TC, HDL and LDL in patients with OSMF as compared to the controls. Their study also showed no significant changes in the levels of TGs and VLDL.…”

Section: Discussionmentioning

confidence: 99%

Serum lipid profile in oral submucous fibrosis: A clinico pathological study

Kanthem

Guttikonda

2015

J Oral Maxillofac Pathol

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Background:Lipids play a key role in the maintenance of cell integrity. These are major cell membrane components essential for various biological functions, including cell growth and division of normal and malignant tissues. Abnormal changes have long been associated with alterations in lipid profile.Aim:The aim of this study was to evaluate the alterations in lipid profile in oral submucous fibrosis (OSMF) patients and to compare the levels with respect to the clinical staging and histological grading.Materials and Methods:Fifty patients of OSMF, diagnosed clinically and histopathologically, were included as the study subjects. A group of 50 age and sex matched normal subjects without any oral pernicious habits were taken as controls. The serum lipid profile consisting of total cholesterol (TC), triglycerides (TGs), high density lipoprotein (HDL), very low density lipoprotein (VLDL) and low density lipoprotein (LDL) were analyzed using Erba Chem-5 Plus Analyzer.Results:Serum TC, HDL and LDL levels were significantly decreased in OSMF patients as compared to controls. As the clinical stage progresses, the TC and HDL levels were gradually reduced. All the lipid profile parameters such as TC, TG, HDL, VLDL and LDL progressively reduced as the histological grade advanced.Conclusion:The results of the present study showed that there is an inverse relationship between lipid profile and the presence of OSMF. The decreased serum lipid profile may be considered as a useful indicator for initial changes occurring in the cells of potentially malignant disorders like OSMF.

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“…18 Oral submucous fibrosis due to its malignant potential is a clinically significant disease. [9][10][11]22 As there is no definitive treatment for Oral sub-mucous fibrosis, thus focus should be placed on prevention, early diagnosis and evaluation of the malignant potential of the disease. Lipids are cell membrane components essential for various biological functions including growth and division of normal and malignant tissues they are also imperative for the structural and functional integrity of biological membranes.…”

Section: Discussionmentioning

confidence: 99%

Mean Lipid Profile among Patients Suffering from Oral Sub-mucous Fibrosis reporting in a Tertiary Care Hospital of Karachi, Pakistan: A Descriptive Study

Siddiq

Shakeel

Haider

et al. 2021

APMC

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Background: Oral Submucous Fibrosis is a potent pre-malignant condition of Oral cavity, which is prevalent in South Asian countries, due to social habit of pan, gutka, areca nut and betel quid chewing, which is mostly practiced in South-East Asia. A decreased pattern of lipid profile has been observed in literature in many precancerous conditions, this study is based on observation of lipid profile pattern among Oral submucous fibrosis patients in relation with age, gender, body mass index and duration of disease. Objective: A descriptive study to determine mean lipid profile values among oral sub-mucous fibrosis patients. Study Design: Descriptive (cross-sectional) study. Settings: Department of Oral & Maxillofacial Surgery, Abbasi Shaheed Hospital-Karachi Pakistan. Duration: 1st January 2017 till 30th June 2017, for a period of six months. Methodology: Oral Sub-mucous Fibrosis (OSMF) patients, who also met with inclusion criteria of study were selected. Lipid Profile values of TC (total cholesterol), HDL (high density lipids), LDL (low density lipids) and triglycerides were observed among OSMF patients in relation to duration of disease, their different age groups, gender and body mass index (BMI). Results: Out of 104 clinically diagnosed patients of OSMF, 34 females and 70 were males. Mean age was 38.9, most of the patients were in the age group of 20-40 years. Mean and standard deviation of TC, triglycerides, LDL and HDL was 132.19±13.29, 142.25±8.71, 101.87±17.57 and 30.43±2.56 respectively. Conclusion: Results of this study revealed that there is no significant change in pattern of lipid profile among OSMF patients in relation to their different age groups, gender and BMI, but an inverse relation does exist between lipid panel and duration of disease.

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Alteration in plasma lipid profile in oral submucous fibrosis patients: A case control study

Cited by 8 publications

References 14 publications

Alteration in Serum Lipid Profile Pattern in Oral Squamous Cell Carcinoma and Potentially Malignant Disorders

Alteration in Serum Lipid Profile Pattern in Oral Squamous Cell Carcinoma and Potentially Malignant Disorders

Serum lipid profile in oral submucous fibrosis: A clinico pathological study

Mean Lipid Profile among Patients Suffering from Oral Sub-mucous Fibrosis reporting in a Tertiary Care Hospital of Karachi, Pakistan: A Descriptive Study

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