Alteration in gut microbiota associated with hepatitis B and non-hepatitis virus related hepatocellular carcinoma

Liu, Qisha; Fan, Liancheng; Zhuang, Yaoyao; Xu, Jian; Wang, Jianwei; Mao, Xuhua; Zhang, Yewei; Liu, Xingyin

doi:10.1186/s13099-018-0281-6

Cited by 162 publications

(163 citation statements)

References 59 publications

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“…Therefore, intestinal overgrowth of E coli may contribute to the process of hepatocarcinogenesis [106]. Recently, non-HBV/HCV-HCC patients harbored more potential pro-inflammatory bacteria (Escherichia-Shigella, Enterococcus) and reduced levels of Faecalibacterium, Ruminococcus, Ruminoclostridium which results in decrease potential of antiinflammatory short-chain fatty acids [107]. In a previous report, phylum Actinobacteria was increased in early HCC versus cirrhosis.…”

Section: Gut Microbiota and Hepatocellular Carcinomamentioning

confidence: 97%

Role of Gut-Microbiota in Hepatocarcinogenesis

Gupta¹,

Youn²,

Shin³

et al. 2019

Preprint

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Hepatocellular carcinoma (HCC), one of the leading causes of death worldwide, has a causal nexus with liver injury, inflammation, and regeneration that accumulate over decades. Observations from recent studies have accounted for the involvement of the gut-liver axis in the pathophysiological mechanism responsible for HCC. The human intestine nurtures a diversified colony of microorganisms residing in the host ecosystem. The intestinal barrier is critical for conserving the normal physiology of the gut microbiome. Therefore, a rupture of this barrier or dysbiosis cause the intestinal microbiome to serve as the main source of portal-vein endotoxins such as lipopolysaccharide, in the progression of hepatic diseases. Indeed, increased bacterial translocation is a key sign of HCC. Considering the limited number of clinical studies on HCC with respect to the microbiome, we focus on the clinical as well as animal studies involving the gut microbiota with the current understandings of the mechanism by which the intestinal dysbiosis promotes hepatocarcinogenesis. Future research might offer mechanistic insights into the specific phyla targeting the leaky gut, as well as microbial dysbiosis, and their metabolites, as key pathways that drive HCC-promoting microbiome-mediated liver inflammation and fibrosis, thereby restoring the gut barrier function.

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Section: Gut Microbiota and Hepatocellular Carcinomamentioning

confidence: 97%

Role of Gut-Microbiota in Hepatocarcinogenesis

Gupta¹,

Youn²,

Shin³

et al. 2019

Preprint

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“…Likewise, according to an Egyptian study, there was a high percentage of Bacteroidetes and a low percentage of Bifidobacterium in hepatitis C virus (HCV) patients [78]. Similarly, in HBV patients, there were increases in Escherichia, Shigella, and Enterococcus and decreases in Bifidobacterium, Faecalibacterium, Ruminococcus, and Ruminiclostridium [79].…”

Section: Microbiota Effects On Chronic Hepatitis B and Cmentioning

confidence: 99%

Interaction of the microbiota with the human body in health and diseases

Altveş

Yıldız

Vural

2020

Bioscience of Microbiota, Food and Health

305

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The human body contains many microorganisms, including a large number of bacteria, viruses, fungi, and protozoa, which are referred to as the microbiota. Compared with the number of cells comprising the human body, that of the microbiota has been found to be much larger. The microbiome is defined as microorganisms and their genomes have been shown to contain about 100 times more genes than the human genome. The microbiota affects many vital functions in the human body. It contributes to regulation of the immune system, digestion of food, production of vitamins such as B12 and K, metabolization of xenobiotic materials, and many other tasks. Many factors affect the microbiota biodiversity, such as diet, medicines including antibiotics, relationships with the environment, pregnancy, and age. Studies have shown that the lack of microbiota diversity leads to many diseases like autoimmune diseases such as diabetes type I, rheumatism, muscular dystrophy, problems in blood coagulation due to lack of vitamin K, and disturbances in the transfer of nerve cells due to lack of vitamin B12, in addition to its involvement in a number of conditions such as cancer, memory disorders, depression, stress, autism, and Alzheimer's disease. The aim of this review is to summarize the latest studies discussing the relationship between the microbiota and the human body in health and diseases.

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“…[38] Also, Liu et al found in his study on patients with different causes of HCC, decreased level of Faecalibacterium resulting in reduction of the level of anti-in ammatory short-chain fatty acids. [39] The family Enterobacteriaceae includes a medically important species such as Salmonella, Escherichia coli, Yersinia pestis, Klebsiella, Shigella, Proteus, Enterobacter, Serratia, and Citrobacter. Many members of this family are normally present in human as a gut microbiota.…”

Section: Variablesmentioning

confidence: 99%

Gut Microbiota Characterization in Patients with HCC Post Chronic HCV Infection

Montasser¹,

Osman²,

Abozaid³

et al. 2020

Preprint

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Aim: Dysbiosis of gut microbiota favors chronic hepatic inflammation with subsequent hepatic carcinogenesis. The current study aimed to evaluate the role of gut dysbiosis in the development of hepatocellular carcinoma in patients with chronic HCV infection.Methods: This descriptive cross-sectional cohort study carried out on 400 subjects recruited from the Internal Medicine Department and Tropical Medicine and Gastroenterology Department of Helwan and South Valley University Hospitals in Egypt. The study period was from January 2017 till January 2020. The subjects were divided clinically into three groups. Group I: One hundred patients with HCC, evaluated by Child Pugh, TNM and BCLC scoring systems. Group II: 200 chronic hepatitis C virus-infected patients. All patients infected with hepatitis C virus genotype 4. Group III: One hundred healthy control subjects with negative hepatitis marker and normal abdominal ultrasound. PCR of stool Microbiota, complete blood counts, complete liver function tests, INR, HCV antibodies and HBsAg were done for all included subjects. HCV PCR assessment and alpha-fetoprotein (AFP) were done for all patients.Results: No statistically significant difference was detected between HCC patients and control (p-value > 0.05) as regard Bacteroides fragilis & Akkermansia muciniphila. Faecalibacterium prausnitzii was less detected in HCC patients (51%), opposite to 70% of healthy control. With Statistically significant difference (p-value < 0.05). Bifidobacterium was less detected in HCC patients (43%), opposite to (76%) of healthy control. With highly statistically significant difference (p-value < 0.001). Lactobacillus & Enterobacteriaceae was more detected in HCC patients (80%) and (81%), in. Opposite to (36%) and (58%) in healthy control, respectively. With highly statistically significant difference (p-value < 0.001). no significant difference was detected between gut-microbiota and HCC progression with respect to Child or TNM systems. However, a significant difference was detected between number of positive stool isolate of Bacteroid Fragilis and BCLC staging system; where it was isolated from 66.7% of patients with BCLC stage IV opposite to 10.7% of patients with BCLC stage I.Conclusion: A characteristic pattern of Bifidobacterium, Lactobacillus and Enterobacteriaceae species in patients with chronic HCV and HCC was detected. Alteration of gut microbiota may be accused as a predisposing factor for liver disease progression.

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Alteration in gut microbiota associated with hepatitis B and non-hepatitis virus related hepatocellular carcinoma

Cited by 162 publications

References 59 publications

Role of Gut-Microbiota in Hepatocarcinogenesis

Role of Gut-Microbiota in Hepatocarcinogenesis

Interaction of the microbiota with the human body in health and diseases

Gut Microbiota Characterization in Patients with HCC Post Chronic HCV Infection

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