Alteration by Diacylglycerols of the Transport and Fatty Acid Composition of Lymph Chylomicrons in Rats

Murata, Masakazu; Hara, Kenji; Ishii, Takashi

doi:10.1271/bbb.58.1416

Cited by 102 publications

(83 citation statements)

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“…PS was used without esteri®cation or hydrogenation. DG was prepared as reported previously (Murata et al, 1994). Brie¯y, glycerol was esteri®ed with fatty acids from rapeseed oil by 1,3-speci®c lipase and puri®ed by silicic acid chromatography.…”

Section: Subjects and Experimental Designmentioning

confidence: 99%

“…Recent studies have suggested that DG consumed in larger amounts may have metabolic characteristics distinct from TG, which may produce bene®cial effects with regard to prevention and management of obesity. Experimental studies in animals and humans have shown that DG reduces postprandial triglyceridemia compared with TG control (Murata et al, 1994;Taguchi et al, 2000). In controlled feeding studies, DG reduced body weight and abdominal fat stores in Japanese men .…”

Section: Introductionmentioning

confidence: 99%

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Solubilization of phytosterols in diacylglycerol versus triacylglycerol improves the serum cholesterol-lowering effect

et al. 2001

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Objective: This study was performed to investigate the difference in the serum-cholesterol-and triglyceridelowering activities between phytosterols dissolved in diacylglycerol (PSaDG) and dispersed in triacylglycerol (PSaTG). The effects of the solvent on the concentrations of serum b-sitosterol and campesterol were examined. Design: The study had a randomised crossover design. Subjects: Twelve healthy normocholesterolemic or moderately hypercholesterolemic men aged 29 ± 50 y participated in this study. Interventions: For 2 weeks before the test period (designated as the control period), all subjects consumed control mayonnaise (PS free) daily with supper and were randomly assigned to two groups for the 2 week test period; one group was given mayonnaise containing PS (500 mgaday) dissolved in DG (10 gaday), and the other mayonnaise containing PS (500 mgaday) dispersed in TG (10 gaday). After a wash out period consuming control PS-free mayonnaise for 4 weeks, the groups were reversed for 2 weeks. Results: PSaTG feeding had no effect on the serum cholesterol level. In contrast, PSaDG feeding signi®cantly reduced the total and LDL cholesterol levels from the initial value of 5.57 to 5.31 mmolal (4.7%; P`0.05) and from 3.69 to 3.39 mmolal (7.6%; P`0.05), respectively. Moreover, the degree of total cholesterol reduction induced by PSaDG feeding in the test period was signi®cantly greater than that induced by PSaTG feeding (P`0.05). In addition, the serum b-sitosterol and campesterol concentrations did not change during the PSaTG or PSaDG feeding periods. Conclusions: Dissolution of PS in DG had a better serum cholesterol lowering effect than dissolution in TG.

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Section: Subjects and Experimental Designmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Solubilization of phytosterols in diacylglycerol versus triacylglycerol improves the serum cholesterol-lowering effect

et al. 2001

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“…Recent studies in animals and humans suggest that oral ingestion of diacylglycerol (DAG), specifically 1,3-DAG, results in lower postprandial triglyceride (TG) levels in plasma compared with levels after ingestion of triacylglycerol (TAG) with similar FA composition (1)(2)(3)(4)(5). These differences occur despite the comparable digestibility and energy content of the two emulsions (6).…”

mentioning

confidence: 99%

“…Recent studies in rodents with DAG have indicated that it may be metabolized by distinct pathways in the gastrointestinal tract when administered orally (2,7,9,17,18). In addition, several physicochemical properties of DAG with respect to the water-oil interface and emulsification have been reported to differ from those of TAG as a result of DAG's greater hydrophilicity (19).…”

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confidence: 99%

Effects of triacylglycerol and diacylglycerol oils on blood clearance, tissue uptake, and hepatic apolipoprotein B secretion in mice

Yasunaga

Saito

Zhang

et al. 2007

Journal of Lipid Research

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Prior studies have suggested that FAs liberated in the small intestine from ingested 1,3-diacylglycerol (DAG) are inefficiently incorporated into triglyceride (TG) in enterocytes, with less chylomicron TG entering the circulation postprandially. We found less TG, but more monacylglyerol and DAG, with similar total acylglycerol in newly secreted chylomicrons after oral DAG or triacylglycerol (TAG). However, clearance of DAG-chylomicrons was more rapid than that of TAG-chylomicrons; this was associated with more efficient in vitro LPL-mediated lipolysis of DAG-derived chylomicrons. Intravenously infused DAG was also cleared faster than TAG in normal mice, via both LPL-mediated lipolysis and apolipoprotein E (apoE)-dependent hepatic uptake. Infusions of TAG, but not DAG, increased plasma TG levels. Greater delivery of DAG-derived FA to the liver during infusion of DAG led to greater TG secretion versus TAG; this allowed the maintenance of similar hepatic TG levels after DAG and TAG infusions. Of note, apoB secretion was similar after DAG versus TAG, indicating the assembly of larger very low density lipoproteins after DAG. In conclusion, reduced plasma TG levels, after oral or intravenous DAG, result from more efficient clearance of DAG by both LPL lipolysis and apoE-mediated hepatic endocytosis. DAG emulsions may by useful for intravenous nutrition in people with preexisting

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“…The chylomicrons are secreted into the lymphatic system and carried by the thoracic lymphatic duct to the vena cava where they enter the circulation. Several researches were trying to demonstrate the mechanism of lipid absorption and transport using thoracic duct cannulation technique in rats (9)(10)(11)(12)(13)(14)(15).…”

Section: Discussionmentioning

confidence: 99%

Effect of Molecular Forms on Distribution of Docosahexaenoic Acid into Organs in Mice.

et al. 2003

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Alteration by Diacylglycerols of the Transport and Fatty Acid Composition of Lymph Chylomicrons in Rats

Cited by 102 publications

References 1 publication

Solubilization of phytosterols in diacylglycerol versus triacylglycerol improves the serum cholesterol-lowering effect

Solubilization of phytosterols in diacylglycerol versus triacylglycerol improves the serum cholesterol-lowering effect

Effects of triacylglycerol and diacylglycerol oils on blood clearance, tissue uptake, and hepatic apolipoprotein B secretion in mice

Effect of Molecular Forms on Distribution of Docosahexaenoic Acid into Organs in Mice.

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