ALTERAÇÕES TEGUMENTARES EM DUAS DIFERENTES LINHAGENS DE Schistosoma mansoni SUBMETIDAS A TRATAMENTO COM ARTEMISININA E ÁCIDO ARTESÚNICO

Schistosomiasis is a neglected parasitic tropical disease that claims around 200,000 human lives every year. Praziquantel (PZQ), the only drug recommended by the World Health Organization for the treatment and control of human schistosomiasis, is now facing the threat of drug resistance, indicating the urgent need for new effective compounds to treat this disease. Therefore, globally, there is renewed interest in natural products (NPs) as a starting point for drug discovery and development for schistosomiasis. Recent advances in genomics, proteomics, bioinformatics, and cheminformatics have brought about unprecedented opportunities for the rapid and more cost-effective discovery of new bioactive compounds against neglected tropical diseases. This review highlights the main contributions that NP drug discovery and development have made in the treatment of schistosomiasis and it discusses how integration with virtual screening (VS) strategies may contribute to accelerating the development of new schistosomidal leads, especially through the identification of unexplored, biologically active chemical scaffolds and structural optimization of NPs with previously established activity.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

334 Leonard St

Brooklyn, NY 11211

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

ALTERAÇÕES TEGUMENTARES EM DUAS DIFERENTES LINHAGENS DE Schistosoma mansoni SUBMETIDAS A TRATAMENTO COM ARTEMISININA E ÁCIDO ARTESÚNICO

Cited by 2 publications

References 0 publications

Immunomodulating and Anti-parasitary Mechanisms of Plant Products in the Treatment of Schistosomiasis

Immunomodulating and Anti-parasitary Mechanisms of Plant Products in the Treatment of Schistosomiasis

Natural Products as Leads in Schistosome Drug Discovery

Contact Info

Product

Resources

About