Alterações nos níveis de colesterol, triglicerídeo e fosfolipídeo total em plasma de Callithrix jacchus (sagüi) reinfectado por Schistosoma mansoni

Ramos, Thadzia Maria de Brito; Vasconcelos, Amanda Soares de; Carvalho, Vera C. O.; Lima, Vera Lúcia de Menezes

doi:10.1590/s0037-86822004000100010

Cited by 12 publications

(9 citation statements)

References 23 publications

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“…These results are in agreement with Soares et al 25 , who showed that patients with VL had high triglycerides levels and low HDL, LDL and total cholesterol levels. Other studies of visceral leishmaniasis and other infectious diseases, such as HIV and schistosomiasis, have reported the same lipid changes 28,[51][52][53][54] . Our fi ndings show that patients with active VL, which most likely have a high parasite load, have total cholesterol levels lower than the control group, and after treatment, these levels increase.…”

Section: Discussionsupporting

confidence: 53%

Biochemical and nutritional evaluation of patients with visceral leishmaniasis before and after treatment with leishmanicidal drugs

Gatto

Abreu

Tasca

et al. 2013

Rev. Soc. Bras. Med. Trop.

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Revista da Sociedade Brasileira de Medicina Tropical 46(6):735-740, Nov-Dec, 2013http://dx.doi.org/10.1590/0037-8682-0198-2013 ABSTRACT Introduction: Visceral leishmaniasis (VL) is caused by the intracellular protozoan Leishmania donovani complex. VL may be asymptomatic or progressive and is characterized by fever, anemia, weight loss and the enlargement of the spleen and liver. The nutritional status of the patients with VL is a major determinant of the progression, severity and mortality of the disease, as it affects the clinical progression of the disease. Changes in lipoproteins and plasma proteins may have major impacts in the host during infection. Thus, our goal was evaluate the serum total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides, glucose, albumin, globulin and total protein levels, as well as the body composition, of VL patients before and after treatment. Methods: Nutritional evaluation was performed using the bioelectrical impedance analysis (BIA) to assess body composition. Biochemical data on the serum total cholesterol, HDL, LDL, triglycerides, glucose, albumin, globulin and total protein were collected from the medical charts of the patients. Results: BIA indicated that both pre-treatment and post-treatment patients exhibited decreased phase angles compared to the controls, which is indicative of disease. Prior to treatment, the patients exhibited lower levels of total body water compared to the controls. Regarding the biochemical evaluation, patients with active VL exhibited lower levels of total cholesterol, HDL, LDL and albumin and higher triglyceride levels compared to patients after treatment and the controls. Treatment increased the levels of albumin and lipoproteins and decreased the triglyceride levels. Conclusions: Our results suggest that patients with active VL present biochemical and nutritional changes that are reversed by treatment. INTRODUCTION

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Section: Discussionsupporting

confidence: 53%

Biochemical and nutritional evaluation of patients with visceral leishmaniasis before and after treatment with leishmanicidal drugs

Gatto

Abreu

Tasca

et al. 2013

Rev. Soc. Bras. Med. Trop.

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“…In studies with humans and marmosets ( Callithrix jacchus ) the plasmatic levels of total cholesterol, esterified cholesterol, triglycerides and phospholipids were significantly reduced after infection with S. mansoni [52,53]. Similar effect was observed by Doenhoff and colleagues, who reported a reduction in atherosclerosis in rats predisposed to cardiovascular disease (apoE -/- ) after infection with S. mansoni [54].…”

Section: Resultsmentioning

confidence: 60%

“…They suggested that this reduction could be due to a modulatory effect of the infection by S. mansoni on lipid metabolism in the host. On the other hand, Ramos and colleagues proposed that the cholesterol reduction could be caused by changes in the LCAT and/or ACAT (acyl-CoA-cholesterol acyl transferase) activity, synthesis or secretion produced by the liver of infected animals [52]. Taking into consideration that schistosomes are not capable of synthesizing cholesterol [55,56], the fact that sexual pairing has an effect upon so many genes related to fatty acid and cholesterol metabolism in male worms becomes even more relevant.…”

Section: Resultsmentioning

confidence: 99%

Microarray analysis of gene expression induced by sexual contact in Schistosoma mansoni

et al. 2007

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Background: The parasitic trematode Schistosoma mansoni is one of the major causative agents of Schistosomiasis, a disease that affects approximately 200 million people, mostly in developing countries. Since much of the pathology is associated with eggs laid by the female worm, understanding the mechanisms involved in oogenesis and sexual maturation is an important step towards the discovery of new targets for effective drug therapy. It is known that the adult female worm only develops fully in the presence of a male worm and that the rates of oviposition and maturation of eggs are significantly increased by mating. In order to study gene transcripts associated with sexual maturation and oviposition, we compared the gene expression profiles of sexually mature and immature parasites using DNA microarrays.

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“…From animal model studies, it is generally agreed that S. mansoni infection reduces levels of plasma cholesterol and triglycerides in both rodents [11], [12] and non-human primates [13], [14]. Nevertheless, the mechanisms behind these changes and the possible consequences for human health are not well understood.…”

Section: Introductionmentioning

confidence: 99%

Human Plasma Lipid Modulation in Schistosomiasis Mansoni Depends on Apolipoprotein E Polymorphism

et al. 2014

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BackgroundSchistosomiasis mansoni is a parasitic liver disease, which causes several metabolic disturbances. Here, we evaluate the influence of Apolipoprotein E (APOE) gene polymorphism, a known modulator of lipid metabolism, on plasma lipid levels in patients with hepatosplenic schistosomiasis.Methodology/Principal FindingsBlood samples were used for APOE genotyping and to measure total cholesterol (TC), LDL-C, HDL-C and triglycerides. Schistosomiasis patients had reduced TC, LDL-C and triglycerides (25%, 38% and 32% lower, respectively; P<0.0001) compared to control individuals, whereas HDL-C was increased (10% higher; P = 0.0136). Frequency of the common alleles, ε2, ε3 and ε4, was similar (P = 0.3568) between controls (n = 108) and patients (n = 84), implying that APOE genotype did not affect susceptibility to the advanced stage of schistosomiasis. Nevertheless, while patient TC and LDL-C levels were significantly reduced for each allele (except TC in ε2 patients), changes in HDL-C and triglycerides were noted only for the less common ε2 and ε4 alleles. The most striking finding, however, was that accepted regulation of plasma lipid levels by APOE genotype was disrupted by schistosomiasis. Thus, while ε2 controls had higher TC and LDL-C than ε3 carriers, these parameters were lower in ε2 versus ε3 patients. Similarly, the inverse relationship of TG levels in controls (ε2>ε3>ε4) was absent in patients (ε2 or ε4>ε3), and the increase in HDL-C of ε2 or ε4 patients compared to ε3 patients was not seen in the control groups.Conclusion/SignificanceWe confirm that human schistosomiasis causes dyslipidemia and report for the first time that certain changes in plasma lipid and lipoprotein levels depend on APOE gene polymorphism. Importantly, we also concluded that S. mansoni disrupts the expected regulation of plasma lipids by the different ApoE isoforms. This finding suggests ways to identify new metabolic pathways affected by schistosomiasis and also potential molecular targets to treat associated morbidities.

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Alterações nos níveis de colesterol, triglicerídeo e fosfolipídeo total em plasma de Callithrix jacchus (sagüi) reinfectado por Schistosoma mansoni

Abstract: RESUMO Pouco se conhece a cerca de alterações nos lipídeos plasmáticos devido à reinfecção por

Cited by 12 publications

References 23 publications

Biochemical and nutritional evaluation of patients with visceral leishmaniasis before and after treatment with leishmanicidal drugs

Biochemical and nutritional evaluation of patients with visceral leishmaniasis before and after treatment with leishmanicidal drugs

Microarray analysis of gene expression induced by sexual contact in Schistosoma mansoni

Human Plasma Lipid Modulation in Schistosomiasis Mansoni Depends on Apolipoprotein E Polymorphism

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