Alterações na bioquímica hepática em cães com leptospirose aguda determinada por amostras do sorogrupo Icterohaemorrhagiae

Freire, Isabel Maria Alexandre; Varges, Renato; Lilenbaum, Walter

doi:10.1590/s0103-84782008005000020

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…The serovar Icterohaemorragiae is especially implicated with hepatic lesions, and the serovar Canicola mainly with renal lesions. Other serovars could affect both organs, although the lesions can be less marked than both the serovars aforementioned (Freire et al 2008, Adler & de la Pena-Moctezuma 2010. Hepatic and renal lesions found in the dogs of the present study varied among serovars and no correlation was found with a specific serovar.…”

Section: Discussioncontrasting

confidence: 63%

Differential diagnoses in 83 dogs with icterus

et al. 2020

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Icterus (jaundice) is a yellowish pigmentation resulting from the depositing of bilirubin in tissues due to its high plasmatic concentration. The pathogenesis of icterus includes metabolic changes or obstructed bilirubin excretion and it is classified as pre-hepatic, hepatic and post-hepatic. This study aimed to evaluate and classify different causes of icterus in dogs during post mortem examination. These dogs were examined from 2014 to 2017, using macroscopic and histologic exams as well as ancillary tests. Eighty-three dogs were examined macroscopically and microscopically. They were separated into groups of icterus types: 24 (28.9%) dogs had pre-hepatic icterus, 45 (54.2%) had hepatic, 13 (15.7%) pre-hepatic and hepatic and one (1.2%) had post-hepatic icterus. Many factors were identified as a cause of icterus, including infectious agents (51/83), neoplasms (13/83), hepatic degeneration (11/83), chronic hepatic diseases (6/83), and obstructive causes (1/87). Among the infectious causes, leptospirosis, ehrlichiosis and disorders suggestive of septicemia were diagnosed. Neoplasms associated with icterus were cholangiocarcinoma, hemangiosarcoma and lymphoma. Other causes of icterus included degenerative diseases, such as lipidosis and glycogen degeneration. Hepatic fibrosis (cirrhosis) as a chronic disease and cholelithiasis also produced icterus. PCR was performed to confirm leptospirosis and ehrlichiosis. Samples of total DNA were used to amplify a fragment of a gene from Leptospira interrogans and Ehrlichia canis. In some dogs, co-infection of these agents was detected. The classification and identification of icterus etiologies in dogs is very important due to the number of diseases with this alteration, where ante mortem diagnosis is not always easily performed when some of these conditions are present.

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Section: Discussioncontrasting

confidence: 63%

Differential diagnoses in 83 dogs with icterus

et al. 2020

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“…As alterações laboratoriais mais comumente encontradas nos exames complementares nos animais com leptospirose aguda são leucocitose com desvio à esquerda, anemia, trombocitopenia, altos níveis de ureia sanguínea e creatinina sérica (VAN DE MAELE et al 2008), elevação da atividade de enzimas hepáticas (FREIRE et al, 2008;COSTA et al, 2013;GREENE, 2015 (McBRIDE et al, 2005;SILVEIRA et al, 2017). Diversos estudos realizados em cães relatam que os títulos de anticorpos aglutinantes desenvolvidos pós vacinação são de baixa intensidade (ANDRÉ-FONTAINE et al, 2003;KOIZUMI & WATANABE, 2005) e possuem curta duração (BARR et al, 2005;RODRIGUES et al 2013…”

Section: Introductionunclassified

Pesquisa sorológica de sorovares de leptospiras que mais frequentemente infectam e causam doença em cães com suspeita clínica de leptospirose

Scandura

Saldanha

Hernandez

et al. 2020

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Leptospirosis is a worldwide zoonosis affecting a wide variety of mammalian species in which the canine species is considered an important host for maintaining the disease in the environment. Considering the importance of canine leptospirosis for public health, this study aims was to verify the probable serovars that most frequently infect and cause the disease in dogs with clinical suspicion of acute leptospirosis. A total of 14 blood samples were collected from dogs with clinical suspicion of acute leptospirosis treated at the Veterinary Hospital of the Methodist University of São Paulo and destined for the investigation of antileptospiras antibodies by microscopic serum agglutination technique. serum urea and creatinine, liver enzyme activity and total bilirubin concentration. The clinical laboratory findings in this study showed significant renal and hepatic impairment in the affected animals with predominance of Copenhageni serovar, in addition to the occurrence of Brastilava serovar. In Brazil serovar Copenhageni, representative of the serogroup Icterohaemorrhagiae, is considered endemic in the canine population and in humans and responsible for severe cases of the disease in these species. These results suggest the implementation of canine vaccination strategies to mitigate this trend, since most vaccines include this serovar in the formulation.

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Alterações na bioquímica hepática em cães com leptospirose aguda determinada por amostras do sorogrupo Icterohaemorrhagiae

Cited by 2 publications

References 7 publications

Differential diagnoses in 83 dogs with icterus

Differential diagnoses in 83 dogs with icterus

Pesquisa sorológica de sorovares de leptospiras que mais frequentemente infectam e causam doença em cães com suspeita clínica de leptospirose

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