Alterações farmacocinéticas de antimicrobianos em situações especiais: uma revisão narrativa

Sousa, Camila Tavares; Frade, Virgínia Paula; Vieira, Letícia; Sales, Thaís Lorenna Souza; Gomes, Gabrielle Kéfrem Alves; Sanches, Cristina

doi:10.24220/2318-0897v27n3a4014

Cited by 4 publications

(8 citation statements)

References 103 publications

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“…Studies of essential oils containing spathulenol as a major compound have reported some biological activities, such as antiproliferative, anti-inflammatory, and antimicrobial activities. And in this sense, do Nascimento et al (2018) investigated antiinflammatory, antiproliferative activity against MCF-7 and OVCAR-3 cell lines of essential oil extracted from Psidium guineense (Myrtaceae) leaves. The results indicated the presence of 80.7% spathulenol.…”

Section: Essential Oil Dexamethasonementioning

confidence: 99%

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Bioactives of the essential oil from the leaves of Eugenia pyriformis Cambess (Myrtaceae) on the effects of tobacco

de Medeiros,

Rodrigues,

Sakumoto

et al. 2024

Front. Pharmacol.

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IntroductionLung cancer is the most commonly diagnosed and the main cause of cancer death, usually related to cigarette smoking. Furthermore, the microbiota of people exposed to cigarette smoke can be modified, making it difficult to eliminate opportunistic microorganisms. The leaves of Eugenia pyriformis are a by-product of fruit production and, to date, there have been no studies addressing the antiproliferative, anti-inflammatory, and antimicrobial activities.ObjectiveInvestigate the antimicrobial, Nitric Oxide (NO)-production inhibition, and antiproliferative activities of the essential oil from E. pyriformis leaves and its possible effect on the treatment and prevention of damage caused by tobacco.MethodsThe essential oil (EO) was obtained by hydrodistillation (3 h). Its chemical composition was investigated by GC-MS. It was proposed to investigate antiproliferative activity against human tumor cell lines, namely, breast adenocarcinoma (MCF-7), lung (NCI-H460), cervical (HeLa), and hepatocellular (HepG2) carcinomas. A non-tumor primary culture from pig liver (PLP2) was also tested. The EO capacity to inhibit nitric oxide (NO) production was evaluated by a lipopolysaccharide stimulated murine macrophage cell line. Antibacterial and antifungal activities against opportunistic pathogens were investigated against seven strains of bacteria and eight fungi.ResultsThe results indicated the presence of 23 compounds in the essential oil, the majority were spathulenol (45.63%) and β-caryophyllene oxide (12.72%). Leaf EO provided 50% inhibition of nitric oxide production at a concentration of 92.04 µg mL−1. The EO also demonstrated antiproliferative activity against all human tumor cell lines studied, with GI50 values comprised between 270.86 and 337.25 µg mL−1. The essential oil showed antimicrobial potential against the bacteria Listeria monocytogenes (Murray et al.) Pirie (NCTC 7973) and Salmonella Typhimurium ATCC 13311 (MIC 1870 µg mL−1) and fungi Aspergillus versicolor ATCC 11730, Aspergillus ochraceus ATCC 12066, Penicillium ochrochloron ATCC 90288, Penicillium verrucosum var. cyclopium (Westling) Samson, Stolk & Hadlok (food isolate) (MIC 1870 µg mL−1) and Trichoderma viride Pers. IAM 5061 (1,400 µg mL–1).ConclusionThe demonstrated anti-inflammatory, antiproliferative, and antimicrobial activities in the leaves of E. pyriformis can add value to the production chain of this plant, being a possible option for preventing and combating cancer, including lung cancer.

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Section: Essential Oil Dexamethasonementioning

confidence: 99%

“…Cigarette smoke contains several chemical constituents, including polycyclic aromatic hydrocarbons, which are mainly responsible for altering liver enzymes. The pathophysiological changes present in smoking can affect the absorption, distribution, metabolism, and excretion processes ( de Sousa et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Bioactives of the essential oil from the leaves of Eugenia pyriformis Cambess (Myrtaceae) on the effects of tobacco

de Medeiros,

Rodrigues,

Sakumoto

et al. 2024

Front. Pharmacol.

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“…Vários órgãos são capazes de metabolizar fármacos, mas essa função é exercida, principalmente, pelo fígado (SULAIMAN et al, 2022), é essencial conhecer quais alterações farmacocinéticas que estão ocorrendo para a determinação de esquemas posológicos adequados, assim aumentando a eficácia antimicrobiana e diminuindo seus efeitos adversos e tóxicos (SOUSA et al, 2018).…”

Section: Introductionunclassified

A influência negativa do consumo de álcool na farmacocinética de antimicrobianos: revisão sistemática

De Souza,

Zurita,

Nascimento

et al. 2023

Braz. J. Develop.

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INTRODUÇÃO: Os antimicrobianos são medicamentos que possuem a finalidade de eliminar ou impossibilitar a multiplicação de bactérias, seu uso inadequado é um dos principias fatores para o surgimento da resistência bacteriana, quando ingerido com bebida alcoólica durante o tratamento com o Metronidazol pode causar efeitos adversos grave como a redução da absorção de medicamento no organismo ocasionando alterações fisiológicas no trato gastrointestinal e na farmacocinética do medicamento. OBJETIVO: Identificar quais as influências negativas do consumo de álcool na farmacocinética de antimicrobianos, METODOLOGIA: Estudo de revisão sistemática utilizando o método PRISMA e usando as palavras chaves: Interação medicamento-álcool, Medicamentos Antimicrobianos-álcool, Interação Medicamentosa do Álcool com os Antibióticos, Efeitos Adversos ao uso de Álcool/Antimicrobianos, Resistência a Antimicrobianos e Farmacocinética, álcool e metronidazol. O período analisado foi de 2012 a 2022. Foram incluídos artigos originais de pesquisa quantitativa ou qualitativa. Os critérios de exclusão foram: artigos fora do recorte temporal, idiomas diferentes do inglês, espanhol e português. RESULTADOS: Foram incluídos 14 artigos para compor a revisão sistemática. Foi possível concluir que a associação entre antimicrobianos e álcool é negativa, pois a bebida alcoólica piora o estado de saúde dos pacientes, trazendo complicações, além de influenciar negativamente na farmacocinética dos antibióticos, as interações farmacocinéticas que ocorrem entre o álcool e os antibióticos resultam na alteração da atividade das enzimas hepáticas, alterando a atividade da isoenzima CYP2E1e CPY3A4 do citocromo P450. CONCLUSÃO: Com base nesses achados podemos dizer que o uso do álcool no decorrer do tratamento de enfermidades com a utilização dos antimicrobianos é negativa pois a interação entre antibióticos e álcool ocasiona alteração na farmacocinética dos medicamentos, causando efeitos adversos.

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“…These agents have a high adaptive and transmutation capacity that is linked to their genomic structure, which gives them the exchange of genes between bacteria (EmyInumaru et al, 2019). Thus, bacteria began to promote infectious processes that were only discovered in the 19 th century when research related to these pathogens began (Sousa et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Potential of anaconda body fat oil (Eunectes murinus), in Santarém city, Pará state, Brazil

Araújo¹,

Batista²,

Neto³

et al. 2020

Braz. J. Vet. Med.

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Alterações farmacocinéticas de antimicrobianos em situações especiais: uma revisão narrativa

Cited by 4 publications

References 103 publications

Bioactives of the essential oil from the leaves of Eugenia pyriformis Cambess (Myrtaceae) on the effects of tobacco

Bioactives of the essential oil from the leaves of Eugenia pyriformis Cambess (Myrtaceae) on the effects of tobacco

A influência negativa do consumo de álcool na farmacocinética de antimicrobianos: revisão sistemática

Antimicrobial Potential of anaconda body fat oil (Eunectes murinus), in Santarém city, Pará state, Brazil

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