Alteraciones metabólicas en prepúberes con retraso del crecimiento extrauterino

Espejo, María Ortiz; Gil-Campos, Mercedes; Villanueva, Mamani; Navero, J.L. Pérez

doi:10.1016/j.anpedi.2012.02.011

Cited by 4 publications

(15 citation statements)

References 30 publications

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“…Prepubertal EUGR children have lower levels of adiponectin and greater resistin and tumor necrosis factor-α than non-EUGR children [20,22]. There are no differences with respect to monocyte chemoattractant protein 1, C-reactive protein, hepatocyte growth factor, and interleukin-8.…”

Section: Evidence On Long-term Cardiovascular Involvement In Eugr Childrenmentioning

confidence: 86%

“…Eight articles studied cardiovascular risk in EUGR children. At the prepubertal stage, children with a history of EUGR have higher systolic blood pressure (SBP) and diastolic blood pressure (DBP) than non-EUGR (SBP 113.49 ± 12.39 vs 92.43 ± 11.6 mmHg, p 0.001 and DBP 70.58 ± 11.53 vs 57.05 ± 9.7 mmHg, p 0.001) [20]. Almost half of those children were hypertensive (SBP/DBP in p > 95 in 46-37%) [20].…”

Section: Evidence On Long-term Cardiovascular Involvement In Eugr Childrenmentioning

confidence: 99%

“…At the prepubertal stage, children with a history of EUGR have higher systolic blood pressure (SBP) and diastolic blood pressure (DBP) than non-EUGR (SBP 113.49 ± 12.39 vs 92.43 ± 11.6 mmHg, p 0.001 and DBP 70.58 ± 11.53 vs 57.05 ± 9.7 mmHg, p 0.001) [20]. Almost half of those children were hypertensive (SBP/DBP in p > 95 in 46-37%) [20]. EUGR children have lower high-density lipid cholesterol and higher glycaemic plasma levels, but without clinical relevance [18,21].…”

Section: Evidence On Long-term Cardiovascular Involvement In Eugr Childrenmentioning

confidence: 99%

“…On the other hand, SGA have greater difficulties to overcome at 36 weeks and/or at hospital discharge. The percentage of SGA < 27 weeks with EUGR is very high (97.8%) [3,8,20]. Therefore, it would be of great interest to demonstrate the relevance of the inclusion of SGA as a subgroup of EUGR patients.…”

Section: Research Gapsmentioning

confidence: 99%

“…Evidence on the cardiovascular impact of EUGR is more recent (2008-2014). There are 8 observational studies [18-22, 25, 26, 35] with a low global number of EUGR that mainly concentrate on the work by Ortiz-Espejo et al Alterations in cardiovascular risk factors (hypertension and/or SBP/DBP increase) have been found when compared to non-EUGR [20]. The quantity or quality of body fat [25,26] and regulatory molecules of homeostasis [20,22,35] would help to explain this increased risk.…”

Section: Research Gapsmentioning

confidence: 99%

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Comorbidities in childhood associated with extrauterine growth restriction in preterm infants: a scoping review

et al. 2020

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Extrauterine growth restriction (EUGR) is a frequent morbidity of preterm infants that can affect short-and long-term prognosis as it involves different EUGR-related alterations in growth and neurological development, as well as cardiometabolic risk. However, knowledge about the prognosis of EUGR is scarce. Thus, the objective of this study is to review the evidence regarding EUGR-related comorbidities in childhood by a systematic approach. This review was carried out using the Joanna Briggs Institute Reviewers' Manual Methodology and the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analyses)-Search Extension for scoping review. The MEDLINE and EMBASE databases were used to identify papers published until September 2017. Twenty-four publications were included and 19 examined cohort studies. EUGR is mainly associated with (1) lower weight, length, and head circumference measures in childhood; (2) poor neurodevelopment; and (3) alterations in cardiometabolic risk markers. The definition for EUGR and the populations studied differ among authors.Conclusion: EUGR is mainly associated with poor growth and neurodevelopment, as well as with cardiometabolic alterations in childhood. Evidence is based on observational studies with variability in the included populations due to the lack of consensus regarding the definition for EUGR. Finding a gold standard definition becomes paramount in order to select phenotypes at risk later in life. What is known?• EUGR is a frequent condition of preterm infants. Up to date little is known about the effect of the metabolic programming on prognosis. What is new?• The available evidence, which is based on observational studies with variability in the population and the existing different definitions for EUGR, do not enable appropriate data collection. EUGR is mainly associated with poor growth and neurodevelopment, as well as with cardiometabolic alterations in childhood.

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Section: Evidence On Long-term Cardiovascular Involvement In Eugr Childrenmentioning

confidence: 86%

Section: Evidence On Long-term Cardiovascular Involvement In Eugr Childrenmentioning

confidence: 99%

Section: Evidence On Long-term Cardiovascular Involvement In Eugr Childrenmentioning

confidence: 99%

Section: Research Gapsmentioning

confidence: 99%

Section: Research Gapsmentioning

confidence: 99%

See 3 more Smart Citations

Comorbidities in childhood associated with extrauterine growth restriction in preterm infants: a scoping review

et al. 2020

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Challenges in the growth and development of newborns with extra-uterine growth restriction

Lucaccioni

Berardi

Predieri

2022

Expert Review of Endocrinology & Metabolism

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Biochemical predictors for metabolic syndrome in preterm infants according to weight ratio

Viera¹,

Barreto²,

Silveira³

et al. 2020

Archives of Endocrinology and Metabolism

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Objective: Prematurity and low birth weight predispose preterm infants to cardiovascular disease in later life. Is the metabolic profile of these children impacted by the relation between birth weight and gestational age (GA)? This study aimed to evaluate whether the relationship between birth weight and GA of preterm infants has a positive correlation with the metabolic profile from birth to the sixth month of corrected age. Subjects and methods: This is a longitudinal, prospective study with a cohort of 70 preterm and 54 term infants, who were enrolled in the study and shared into two groups: Appropriate for GA (AGA) and Small for GA (SGA), both classified at birth by Fenton and Kim curves. Longitudinal evaluation of anthropometry measures and blood samples of total cholesterol, glucose, triglycerides, and insulin were collected at birth, NICU discharge, and the sixth month of corrected age. Data were analyzed using descriptive and inferential statistical analysis (ANOVA, Fisher test, Shapiro-Wilk, and Cochran test). The effect size was 0.15, power was 0.92, and confidence interval 95%. Results: No significant statistical differences were observed in relation to biochemical tests between AGA and SGA groups. However, a significant increase in triglyceride results above the reference values for age in the SGA group was observed throughout the follow-up. Conclusions: Changes observed in the preterm infant metabolic profile show no correlation with adequacy of birth weight. Preterm lipid profile requires continuous evaluation at follow-up, due to the increased cardiovascular risk in later life.

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Alteraciones metabólicas en prepúberes con retraso del crecimiento extrauterino

Cited by 4 publications

References 30 publications

Comorbidities in childhood associated with extrauterine growth restriction in preterm infants: a scoping review

Comorbidities in childhood associated with extrauterine growth restriction in preterm infants: a scoping review

Challenges in the growth and development of newborns with extra-uterine growth restriction

Biochemical predictors for metabolic syndrome in preterm infants according to weight ratio

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