Alteraciones hematológicas en trabajadores expuestos ocupacionalmente a mezcla de benceno- tolueno-xileno (BTX) en una fábrica de pinturas

Haro-García, Luis; Vélez-Zamora, Nadia Mayola; Aguilar-Madrid, Guadalupe; Guerrero-Rivera, Susana; Sánchez-Escalante, Vanessa; Muñoz, Sergio; Mezones‐Holguín, Edward; Juárez-Pérez, Cuauhtémoc Arturo

doi:10.1590/s1726-46342012000200003

Cited by 13 publications

(10 citation statements)

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“…Neutropenia associated with the toxicity of chemicals is related to polycyclic aromatic part of benzene derivatives. Decreased WBC counts followed by neutropenia correspond to the main hematologic effect of benzene secondary to hypoplasia and, less frequently, only thrombocytopenia or associated with neutropenia [ 5 , 23 ]. Decreased counts of WBC, neutrophils, lymphocytes, and monocytes were found in the recent study designed to evaluate the hematotoxicity of low-level benzene exposure among workers from a petrochemical factory [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…Exposure to benzene and its derivatives may promote a decrease in hemoglobin concentrations, red blood cell (RBC) counts, WBC counts, and progenitor cells. The absorption of the toluene fraction has been associated with bone marrow damage and impaired hematopoiesis, as observed in animal models; however, more studies are needed to clarify the underlying mechanism [ 5 , 23 , 26 ]. A description of two cases has also verified complex chromosomal rearrangements and lower natural killer (NK) cells in female Brazilian gas station workers who presented benzene poisoning symptoms and miscarriage history [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

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Genetic Polymorphisms Associated with Environmental Exposure to Polycyclic Derivatives in African Children

et al. 2018

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Background The nonracial leukopenia may be a result of exposure to polycyclic derivatives (benzene-toluene-xylene (BTX)) and may arise from a possible change in the bone marrow microenvironment. The present study sought to evaluate the association of genetic polymorphisms in xenobiotic-metabolizing enzymes with hematological and biochemical profiles. Methods We evaluated 89 African descendant children, exposed indirectly to benzene derivatives. Laboratory parameters were investigated by automated methods and genetic polymorphisms by PCR-RFLP and PCR multiplex. Results Children with leukopenia had significantly decreased white blood cells (WBCs) and platelet counts, which is not consistent with benign leukopenia. In the same group, we have found that carriers of the CYP2E1 variant allele had decreased WBC and lymphocytes. Those with NQO1 variant allele had decreased WBC, neutrophil, eosinophil, monocyte, and lymphocyte counts. Carriers of the MPO variant allele had decreased WBC, neutrophil, eosinophil, basophil, monocyte, lymphocyte, and platelet counts and an elevated free iron level. Children with GSTT and GSTM null exhibited decreased WBC, neutrophil, basophil, and lymphocyte counts. Our multivariate analysis model reveals that females were independently associated with leukopenia. Conclusion Our results suggest that the polymorphisms investigated were associated with hematological changes in the studied population. These alterations could be heightened by exposure to benzene derivatives.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Genetic Polymorphisms Associated with Environmental Exposure to Polycyclic Derivatives in African Children

et al. 2018

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“…La OMS no lo considera genotóxico ni carcinógeno en humanos ni animales, pero se ha reportado que en dosis bajas durante largo tiempo puede producir disfunción neurológica y daño hematológico (21). El xileno puede producir efectos neurotóxicos, así como hepatotoxicidad y nefrotoxicidad, y aunque existe controversia sobre su efecto hematotóxico, se sabe que cuando se absorbe por inhalación la exposición prolongada a isómeros de xileno lleva a la formación de productos tóxicos intermedios y finales semejantes a los del benceno, con efectos tóxicos en la médula (22,23).…”

Section: Según La Internacional Agency For Research Inunclassified

Evaluación de la exposición a solventes orgánicos en pintores de carros de la ciudad de Bogotá

et al. 2015

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Contribución de los autores:Ruth Marien Palma: elaboración del protocolo y trabajo de campo Todos los autores participaron en el análisis estadístico de los datos y en la escritura del manuscrito. Introducción. Los pintores de vehículos automotores están expuestos a solventes puros o mezclas, los cuales se han asociado con efectos neurológicos, mutagénicos y cancerígenos. Objetivo. Caracterizar las condiciones de salud y de trabajo de individuos expuestos a solventes orgánicos empleados en talleres de lámina y pintura de carros de Bogotá. Materiales y métodos. Se hizo un estudio transversal descriptivo en el que se caracterizaron las condiciones de salud y de trabajo de individuos expuestos a solventes orgánicos en talleres de lámina y pintura en Bogotá. Se comparó un grupo de trabajadores expuestos a solventes orgánicos con un grupo no expuesto. Se determinaron las concentraciones de benceno, tolueno y xileno en el aire, se hizo una encuesta individual y se midieron los ácidos fenil-mercaptúrico, hipúrico, orto y parametilhipúrico en orina. Los resultados de las mediciones y de la encuesta se correlacionaron para establecer el panorama de exposición. Evaluación de la exposición a solventes orgánicos en pintores de carros de la ciudad de BogotáResultados. Hubo diferencias estadísticamente significativas entre la población expuesta y la no expuesta a solventes (p<0,001) en cuanto a los tres metabolitos de benceno, tolueno y xileno. Se encontraron correlaciones positivas entre el tolueno en el aire y el ácido hipúrico en la orina de los individuos expuestos (ro=0,82), y entre el xileno en el aire y el ácido o-metilhipúrico (ro=0,76). Los valores del ácido hipúrico estuvieron por encima de los límites permisibles en 11 trabajadores y, los de ácido p-metilhipúrico, en ocho de ellos. No se registraron valores de ácido fenil-mercaptúrico por fuera del límite permitido. Conclusión. Los pintores de carros están expuestos a niveles altos de solventes orgánicos en sus sitios de trabajo, y no tienen condiciones adecuadas de higiene y seguridad industrial para realizar sus labores.Palabras clave: solventes, benceno, tolueno, exposición ocupacional.doi: http://dx.doi.org/10.7705/biomedica.v35i0.2268 Evaluation of exposure of auto painters to organic solvents in the city of BogotaIntroduction: Painters of automobiles are exposed to pure and mixed solvents that have been associated with neurological effects and carcinogenic mutations. Objective: To characterize the health and work conditions of individuals who are occupationally exposed to organic solvents used in sheet metal and auto body shops in Bogota. Materials and methods: Descriptive, cross-sectional study that characterizes the health and work conditions of individuals exposed to organic solvents in sheet metal and auto body shops in Bogota. A group exposed to the solvents was compared to an unexposed group. Air concentrations of benzene, toluene and xylene (BTX) were determined, individual questionnaires were administered and phenylmercapturic, hippuric and ortho-and ...

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“…The occupational exposure of painters to organic solvents has been widely studied in industrialized countries, such as Canada, Korea, New Zealand, and Spain, and in emerging economies such as Iran, Pakistan, Thailand, Argentina, Mexico, and Colombia [1], [2], [3], [4], [5], [6], [7], [8], [9], [10]. In addition, the acute effects of organic solvents on the health of workers have also been demonstrated.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the acute effects of organic solvents on the health of workers have also been demonstrated. However, in recent decades, the study of long-term effects (e.g., problems with the nervous system, cognition, memory, motor performance, hematological characteristics, renal status, hepatic symptoms, ototoxicity systems, and cancer risks) on the health of workers exposed to low concentrations of these substances is of interest [6], [9], [11], [12]. Other studies in industrialized countries have analyzed the health risks of paint to auto workers considering occupational, nonoccupational, and environmental exposure as well as the total daily intake and the health risk over the population [6], [10], [13], [14], [15], [16].…”

Section: Introductionmentioning

confidence: 99%

Controlling Painters' Exposure to Volatile Organic Solvents in the Automotive Sector of Southern Colombia

Castaño

Ramírez

Cancelado

2019

Safety and Health at Work

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Background Painters in the automotive sector are routinely exposed to volatile organic solvents, and the levels vary depending on the occupational health and safety controls enforced at the companies. This study investigates the levels of exposure to organic vapors and the existence of controls in the formal economy sector in southern Colombia. Methods This is an exploratory study of an observational and descriptive character. An analysis of solvents is conducted via the personal sampling of painters and the analysis of samples using the National Institute for Occupational Safety and Health 1501 method. The amount of solvents analyzed varied according to the budget allocated by the companies. The person in charge of the occupational safety and health management system was interviewed to learn about the exposure controls implemented at the companies. Results A medium exposure risk for toluene was found in one company. Another presented medium risk for carbon tetrachloride, xylene, ethylbenzene, and n-butanol. The others showed low risk of exposure and that the controls implemented were not sufficient or efficient. Conclusion These results shed light on the working conditions of these tradespeople. The permissible limits established by Colombian regulations for the evaluated chemical contaminants were not exceeded. However, there were contaminants that exceeded the limits of action. The analysis of findings made it possible to propose improvements in occupational safety and health management systems to allow the optimization of working conditions for painters, prevent the occurrence of occupational diseases, and reduce costs to the country's health system.

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Alteraciones hematológicas en trabajadores expuestos ocupacionalmente a mezcla de benceno- tolueno-xileno (BTX) en una fábrica de pinturas

Abstract: All blood cytological components analyzed demonstrated mild changes, potentially associated with exposure to the mixture of BTX. Macrocytosis could constitute an early manifestation worthy for surveillance.

Cited by 13 publications

References 17 publications

Genetic Polymorphisms Associated with Environmental Exposure to Polycyclic Derivatives in African Children

Genetic Polymorphisms Associated with Environmental Exposure to Polycyclic Derivatives in African Children

Evaluación de la exposición a solventes orgánicos en pintores de carros de la ciudad de Bogotá

Controlling Painters' Exposure to Volatile Organic Solvents in the Automotive Sector of Southern Colombia

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