ALTAI and SAYAN

Еманов, А. Ф.; Fateev, A. V.; Shevkunova, E. V.; Podkorytova, V. G.

doi:10.35540/1818-6254.2020.23.11

Cited by 3 publications

(3 citation statements)

References 4 publications

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“…Серед них найбільш складними за біомеханікою, ступенем порушення місцевого кровообігу, втратою кісткової тканини і її регенеративного потенціалу вирізняються осколкові та відкриті переломи. Їх консолідація ускладнюється додатковою травмою великого масиву м'яких тканин, їх розміжченням та просоченням кров'ю з високим ризиком інфікування та розвитку травматичного ендотоксикозу [5]. Формування кісткових дефектів за осколкових переломів зумовлюють технічні складності у проведенні остеосинтезу кісткових уламків.…”

Section: білоцерківський національний аграрний університетunclassified

“…Тим більше, що для досягнення всіх властивостей кісткової тканини остеозаміщувальних матеріалів пропонуються і біологічні -стовбурові клітини, кісткові морфогенетичні білки, фактори росту [5,7,25].…”

Section: білоцерківський національний аграрний університетunclassified

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Dynamics of hematological parameters and acute phase reactions for osteosubstitution by autofibrin and hydroxyapatite ceramics with β-tricalcium phosphate fragmentary bone fractures in dogs

Shevchenko

Rublenko

2022

Nauk. vìsn. vet. med.

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Osteo-replacement materials are considered to be the most promising direction in solving the problem of restoring the regenerative potential of bone tissue, especially fragmentary fractures. However, the mechanism of their influence on the histomorphology of bone regenerates and the pathochemical phase of reparative osteogenesis require further and comprehensive justification. The aim of the study was to establish the dynamics of hematological parameters and acute phase response to osteosubstitution by hydroxyapatite ceramics with β-tricalcium phosphate and platelet-enriched autofibrin in fragmentary bone fractures in dogs. Control and research groups of animals were formed, each of which included dogs with fractures of both shoulder and forearm bones, which came in 2019- 2021 to the clinic of small pets of the Faculty of Veterinary Medicine of Bila Tserkva NAU. After general and local anesthesia, extracortical osteosynthesis and replacement of bone defects were performed: in the first experimental group (n = 10) autofibrin enriched with platelets (PRF), and in the second (n = 10) - its combination with hydroxyapatite ceramics (PRF + HA/β -TCP-700); in the control group (n = 10) the defects were left to heal under the blood clot. Blood samples for hematological and biochemical studies were taken after injury no later than 24 hours and on the 3rd, 7th, 14th, 21st and 42nd day after osteosynthesis. In peripheral blood, the number of erythrocytes, platelets and leukocytes was determined by conventional methods, and hemoglobin - hemoglobin cyanide. The content of nitric oxide (NO) in the blood serum was determined by the method of Green in the modification of Golikov, haptoglobin - by reaction with rivanol kits PJSC "Reagent" (Ukraine) and α2-macroglobulin - by KM Veremeenko. Statistical processing of the results was performed using the program Statistica 10 (StatSoft Inc, USA, 2011). It was found that bone trauma in dogs is accompanied by a decrease in peripheral blood of erythrocytes by 1.3 times (p <0.001) and an increase of 1.1 times (p <0.05) the number of leukocytes with a tendency to increase hemoglobin and platelets, compared with indicators of clinically healthy animals. After osteosynthesis in all groups leukocytosis developed. During osteosubstitution, the intensity and duration of the leukocyte reaction decreased significantly. In the first experimental group, the peak of NO concentration occurred on the 21st day, and in the case of combined osteosubstitution, the phase of its changes was noted, which had two peaks: on the 7th in 1.5 and on the 21st in 1.8 (p <0.001) is several times higher than in the control group. The concentration of haptoglobin after bone injury in dogs increased 1.1 times (p <0.001) compared with clinically healthy animals and reached its peak in all groups on the 3rd day (p <0.001). No changes in α2-macroglobulin concentration were observed in the groups during the entire study period. Combined osteosubstitution by calcium-phosphate ceramics with platelet-enriched fibrin induces early osteogenic processes at a lower intensity of the acute phase reaction at the phase peaks of nitric oxide - an inducer of angiogenesis, which indicates the viability of animals. Key words: nitric oxide, acute phase proteins, reparative potential, platelets.

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Section: білоцерківський національний аграрний університетunclassified

Dynamics of hematological parameters and acute phase reactions for osteosubstitution by autofibrin and hydroxyapatite ceramics with β-tricalcium phosphate fragmentary bone fractures in dogs

Shevchenko

Rublenko

2022

Nauk. vìsn. vet. med.

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“…Другой тип механизмов -с наличием сбросовой компоненты -более характерен для землетрясений Бусийнгольской и Терехольской впадин и их горного обрамления (№ 1, 15, 16, 22). Сдвиги и сбросы в очагах землетрясений являются основными кинематическими типами фокаль ных решений для Бусийнгольской активизации в 2004 г., сильнейший толчок которой 27.12.1991 г. с MS6.5 был «чистым» сдвигом [Emanov et al, 2010].…”

Section: таблица 1 механизмы очагов землетрясений Table 1 Earthquake Focal Mechanismsunclassified

Focal Mechanisms of Earthquakes of Southern Baikal Region and Northern Mongolia

Радзиминович

2021

Geodin. tektonofiz.

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Identification of natural oscillation frequencies of constructions from low-amplitude seismic signals (on the example of the Sayano-Shushenskaya HPP dam according to the monitoring data of 2001-2021)

Лисейкин

Seleznev

Еманов

et al. 2023

RJS

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Based on the spectral analysis of low-amplitude seismic signals records (continuous monitoring data for 2001-2021) from one of the stations of the seismological network located at a distance of 4.4 km from the Sayano-Shushenskaya HPP, a method for determining the daily values of natural oscillation frequencies of constructions has been developed (the frequencies of the first seven modes are identified with an error no more than 0.01 Hz). The results of processing and analysis of unique data indicate a continuous and non–slowing increase in the values of the natural oscillation frequencies of the dam in the range of 0.02-0.05 Hz during the observation period. This is explained either by silting up the bottom of the reservoir in the area adjacent to the dam, or by adapting the dam and its base with subsequent increase in mechanical rigidity of the construction. At the same time, the intervals are analyzed at which the influence of seasonal environmental influences on the construction is insignificant (summer-autumn period, the water level in the reservoir is close to the maximum). The developed method of identification of natural oscillation frequencies of constructions from low-amplitude seismic signals is intended to monitor their technical condition, in order to prevent the risks of destruction of dams, industrial structures, infrastructure facilities and civil buildings with a high degree of reliability and is economically profitable in comparison with known solutions.

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ALTAI and SAYAN

Cited by 3 publications

References 4 publications

Dynamics of hematological parameters and acute phase reactions for osteosubstitution by autofibrin and hydroxyapatite ceramics with β-tricalcium phosphate fragmentary bone fractures in dogs

Dynamics of hematological parameters and acute phase reactions for osteosubstitution by autofibrin and hydroxyapatite ceramics with β-tricalcium phosphate fragmentary bone fractures in dogs

Focal Mechanisms of Earthquakes of Southern Baikal Region and Northern Mongolia

Identification of natural oscillation frequencies of constructions from low-amplitude seismic signals (on the example of the Sayano-Shushenskaya HPP dam according to the monitoring data of 2001-2021)

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