ALS-like skin changes in mice on a chronic low-Ca/Mg high-Al diet

Kihira, Tameko; Yoshida, Sohei; Kondo, Tomoyoshi; Yase, Yoshiro; Ono, Seiitsu

doi:10.1016/j.jns.2003.11.010

Cited by 14 publications

(3 citation statements)

References 27 publications

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“…MT levels are elevated in kidney and liver of ALS patients, and MT expression is increased in the spinal cord of ALS patients . A variety of heavy-metal exposures have been found to lead to ALS or ALS-like symptoms . However, while zinc deficiency was linked to ALS in a 22-person study, heavy metals in toe nails did not correlate with ALS .…”

Section: Als and Ad: Same Thing But Differentmentioning

confidence: 90%

Bioinorganic Chemistry of Alzheimer’s Disease

2012

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Section: Als and Ad: Same Thing But Differentmentioning

confidence: 90%

Bioinorganic Chemistry of Alzheimer’s Disease

2012

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“…Motor neuron degeneration has been shown in mice following Al hydroxide injections (Shaw and Petrik 2009). Motor neuron degeneration with neurofibrillary tangle formation, chromatolysis and abnormal localization of nuclei, resembling ALS pathology, is observed in mice after Al injection (Tanridag et al 1999) and ALS-like skin changes have been observed in mice overfed with Al (Kihira et al 2004). Monkeys recieving a diet low in calcium and high in Al developed ALS motor neuron pathology (Garruto et al 1989).…”

Section: Individual Metals and Links To Als-like Symptomsmentioning

confidence: 99%

Metal Concentrations in Cerebrospinal Fluid and Blood Plasma from Patients with Amyotrophic Lateral Sclerosis

Roos

Vesterberg

Syversen

et al. 2012

Biol Trace Elem Res

151

114

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Amyotrophic lateral sclerosis (ALS) is a progressive and fatal degenerative disorder of motor neurons. The cause of this degeneration is unknown, and different causal hypotheses include genetic, viral, traumatic and environmental mechanisms. In this study, we have analyzed metal concentrations in cerebrospinal fluid (CSF) and blood plasma in a well-defined cohort (n = 17) of ALS patients diagnosed with quantitative electromyography. Metal analyses were performed with high-resolution inductively coupled plasma mass spectrometry. Statistically significant higher concentrations of manganese, aluminium, cadmium, cobalt, copper, zinc, lead, vanadium and uranium were found in ALS CSF compared to control CSF. We also report higher concentrations of these metals in ALS CSF than in ALS blood plasma, which indicate mechanisms of accumulation, e.g. inward directed transport. A pattern of multiple toxic metals is seen in ALS CSF. The results support the hypothesis that metals with neurotoxic effects are involved in the pathogenesis of ALS.

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“…Western scientists have generally ignored these data, in spite of the obvious linkage provided by embryology that both systems are ectodermal in origin [11][12][13][14]. These skin changes can even be demonstrated in animal models of ALS [15].…”

Section: Introductionmentioning

confidence: 99%

Aluminum?s Role in CNS-immune System Interactions leading to Neurological Disorders

CA¹

2013

Immunome Res

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Multisystem interactions are well established in neurological disorders, in spite of conventional views that only the central nervous system (CNS) is impacted. We review evidence for mutual interactions between the immune and nervous systems and show how these seem to be implicated in the origin and progression of nervous system disorders. Well-established immune system triggers leading to autoimmune reactions are considered. Of these, aluminum, a known neurotoxicant, may be of particular importance. We have demonstrated elsewhere that aluminum has the potential to induce damage at a range of levels in the CNS leading to neuronal death, circuit malfunction and ultimately, system failure. Aluminum is widely used as an adjuvant in various vaccine formulations and has been implicated in a multisystem disorder termed "autoimmune/inflammatory syndrome induced by adjuvants" (ASIA). The implications of aluminum-induced ASIA in some disorders of the CNS are considered. We propose a unified theory capturing a progression from a local response to a systemic response initiated by disruption of water-based interfaces of exposed cells.

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ALS-like skin changes in mice on a chronic low-Ca/Mg high-Al diet

Cited by 14 publications

References 27 publications

Bioinorganic Chemistry of Alzheimer’s Disease

Bioinorganic Chemistry of Alzheimer’s Disease

Metal Concentrations in Cerebrospinal Fluid and Blood Plasma from Patients with Amyotrophic Lateral Sclerosis

Aluminum?s Role in CNS-immune System Interactions leading to Neurological Disorders

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