Alprazolam-induced EEG spectral power changes in rhesus monkeys: a translational model for the evaluation of the behavioral effects of benzodiazepines

Berro, Laís F.; Overton, John S; Reeves-Darby, Jaren; Rowlett, James K.

doi:10.1007/s00213-021-05793-z

Cited by 8 publications

(8 citation statements)

References 57 publications

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“…Of note, the studies described above investigating sleep patterns in non-human primates were conducted in adult rhesus monkeys, with ages ranging from 5 to 20 years ( Daley et al, 2006 ; Berro et al, 2017a ; Goonawardena et al, 2018 ). While it is well known from the human literature that aging can influence sleep duration, particularly REM sleep duration ( Roffwarg et al, 1966 ), at least up until 15 years of age we do not see significant changes in sleep architecture with rhesus monkeys (results from the present study), and up to 20 years old, no age-related changes in actigraphy-based sleep have been reported ( Berro et al, 2021b ). We have previously reported that one 25 year old monkey in our colony showed longer baseline sleep latency and shorter baseline sleep duration compared to other monkeys (subject 98-003, Berro et al, 2021a ).…”

Section: Discussioncontrasting

confidence: 84%

“…Monkeys were weighed monthly during physical examinations, and amount of chow for each monkey was determined in consultation with veterinary staff to be that which maintains healthy weights in rhesus monkeys. All four subjects participated in a previous study investigating the effects of acute benzodiazepine administrations ( Berro et al, 2021b ). Animals had been previously exposed to five acute benzodiazepine administrations at least 2 days apart, with the last administration being conducted at least 3 months prior to the beginning of the current study ( Berro et al, 2021b ).…”

Section: Methodsmentioning

confidence: 99%

“…All four subjects participated in a previous study investigating the effects of acute benzodiazepine administrations ( Berro et al, 2021b ). Animals had been previously exposed to five acute benzodiazepine administrations at least 2 days apart, with the last administration being conducted at least 3 months prior to the beginning of the current study ( Berro et al, 2021b ). Therefore, the animals’ previous experimental history likely did not contribute to the present findings.…”

Section: Methodsmentioning

confidence: 99%

“…The monkeys were prepared with a telemetry implant according to the surgical procedures described in detail by Berro et al (2021b) at least 1 month prior to the beginning of tests. Briefly, the fully implantable telemetry devices [Model L04 PhysioTelTM Digital; Data Sciences International ® (DSI), St-Paul, MN] consisted of an implant device (implant weight: 56 g; implant volume: 29cc; implant dimensions: 59 × 38 × 15 mm) attached to a small antenna and to 8 leads, 2 for each biopotential channel (4 channels total).…”

Section: Methodsmentioning

confidence: 99%

“…Sleep-wake states were determined by visual inspection of EEG, EMG and EOG signals using NeuroScore software (version 3.2.0; DSI, St. Paul, MN, United States) according to the American Academy of Sleep Medicine (AASM) guidelines for adult human sleep scoring (Manual version 2.5; Berry et al, 2018 ), adapted for rhesus monkeys ( Berro et al, 2021b ). Sleep-wake state scoring was conducted based on recordings from the central derivation (C4-Cz).…”

Section: Methodsmentioning

confidence: 99%

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Methamphetamine-Induced Sleep Impairments and Subsequent Slow-Wave and Rapid Eye Movement Sleep Rebound in Male Rhesus Monkeys

2022

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Use of amphetamine-type stimulants is associated with numerous adverse health outcomes, with disturbed sleep being one of the most prominent consequences of methamphetamine use. However, the extent to which methamphetamine alters sleep architecture, and whether methamphetamine-induced sleep impairment is associated with next-day sleep rebound effects, has received relatively little investigation. In the present study, we investigated the effects of acute morning methamphetamine administration on sleep parameters in adult male rhesus monkeys (N = 4) using a fully-implantable telemetry system. Monkeys were prepared with telemetry devices that continuously monitored electroencephalography (EEG), electromyography (EMG) and electrooculography (EOG) throughout the night. We investigated the effects of morning (10h00) administration of methamphetamine (0.01–0.3 mg/kg, i.m.) on sleep during the night of the injection. In addition, we investigated sleep during the subsequent night in order to assess the possible emergence of sleep rebound effects. Methamphetamine administration dose-dependently increased sleep latency and wake time after sleep onset (WASO). Methamphetamine also decreased total sleep time, which was reflected by a decrease in total time spent in N2, slow-wave (N3) and REM sleep stages, while increasing the percentage of total sleep time spent in sleep stage N1. Importantly, methamphetamine decreased time spent in N3 and REM sleep even at doses that did not significantly decrease total sleep time. Sleep rebound effects were observed on the second night after methamphetamine administration, with increased total sleep time reflected by a selective increase in time spent in sleep stages N3 and REM, as well as a decrease in REM sleep latency. Our findings show that methamphetamine administered 8 h prior to the inactive (dark) phase induces marked changes in sleep architecture in rhesus monkeys, even at doses that do not change sleep duration, and that sleep rebound effects are observed the following day for both N3 and REM sleep stages.

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