Alprazolam and lorazepam effects on memory acquisition and retrieval processes

A method for determining the magnitude of change across different cognitive functions in clinical trials: the effects of acute administration of two different doses alprazolam

“…In addition to using different tests, many studies infer that a cognitive function is impaired following treatment with a benzodiazepine according to the basis of statistically significant differences between baseline and treatment conditions, or between treatment and placebo conditions (Block, 1984;Linnoila et al, 1990;Saletu et al, 1994;Verster et al, 2002). However, statistical significance indicates only the probability that the null hypothesis has been rejected incorrectly.…”

Effects of alprazolam and lorazepam on catecholaminergic and cardiovascular activity during supine rest, mental load and orthostatic challenge

“…This does not make it easy to estimate the concentrations and activity of both compounds at the central benzodiazepine receptor when serum concentrations are similar. Some experiments on memory and psychomotor functions have shown 0.5 mg alprazolam and 1 mg lorazepam to be equivalent (Block and Berchou 1984;Subhan et al 1986;Kumar et al 1987). In view of these data and the parallel time course of the plasma concentration curves in this experiment, it would appear that the differences observed in this study cannot be ascribed to differences in potency of alprazolam and lorazepam at the doses investigated.…”

Mood and Performance Changes in Women with Premenstrual Dysphoric Disorder Acute Effects of Alprazolam

“…Therapeutic doses of alprazolam also produce sedation and impair psychomotor performance and memory (e.g., Aranko et al 1985;Block and Berchou 1984;Linnoila et al 1990;Evans et al 1994). Two recent studies reported that women with PMS had reduced sensitivity to benzodiazepines, which was more pronounced in the luteal phase, compared to women without PMS (Sundström et al 1997a,b).…”