ALPPS (Associated Liver Partition and Portal vein ligation for Staged hepatectomy) – gyorsabb, nagyobb májhypertrophia

Hahn, Oszkár; Dudás, Ibolyka; Pajor, Péter; Györke, Tamás; Korom, Csaba; Zsirka-Klein, Attila; Kempler, Péter; Harsányi, László

doi:10.1556/maseb.66.2013.1.3

Cited by 8 publications

(3 citation statements)

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“…[9]–[11] Tumor progression in the liver between the time of PVL/PVE and the next phase of hepatectomy is responsible for the majority of changes into irresectable state which occurs in approximately 20% of the cases of planned for two-stage surgeries. [12], [13].…”

Section: Introductionmentioning

confidence: 99%

Demonstration of Metabolic and Cellular Effects of Portal Vein Ligation Using Multi-Modal PET/MRI Measurements in Healthy Rat Liver

et al. 2014

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ObjectivesIn the early recognition of portal vein ligation (PVL) induced tumor progression, positron emission tomography and magnetic resonance imaging (PET/MRI) could improve diagnostic accuracy of conventionally used methods. It is unknown how PVL affects metabolic patterns of tumor free hepatic tissues. The aim of this preliminary study is to evaluate the effect of PVL on glucose metabolism, using PET/MRI imaging in healthy rat liver.Materials and MethodsMale Wistar rats (n = 30) underwent PVL. 2-deoxy-2-(18F)fluoro-D-glucose (FDG) PET/MRI imaging (nanoScan PET/MRI) and morphological/histological examination were performed before (Day 0) and 1, 2, 3, and 7 days after PVL. Dynamic PET data were collected and the standardized uptake values (SUV) for ligated and non-ligated liver lobes were calculated in relation to cardiac left ventricle (SUVVOI/SUVCLV) and mean liver SUV (SUVVOI/SUVLiver).ResultsPVL induced atrophy of ligated lobes, while non-ligated liver tissue showed compensatory hypertrophy. Dynamic PET scan revealed altered FDG kinetics in both ligated and non-ligated liver lobes. SUVVOI/SUVCLV significantly increased in both groups of lobes, with a maximal value at the 2nd postoperative day and returned near to the baseline 7 days after the ligation. After PVL, ligated liver lobes showed significantly higher tracer uptake compared to the non-ligated lobes (significantly higher SUVVOI/SUVLiver values were observed at postoperative day 1, 2 and 3). The homogenous tracer biodistribution observed before PVL reappeared by 7th postoperative day.ConclusionThe observed alterations in FDG uptake dynamics should be taken into account during the assessment of PET data until the PVL induced atrophic and regenerative processes are completed.

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Section: Introductionmentioning

confidence: 99%

Demonstration of Metabolic and Cellular Effects of Portal Vein Ligation Using Multi-Modal PET/MRI Measurements in Healthy Rat Liver

et al. 2014

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“…a teljes esetszám 5%-át operáltuk. 16 Innovatív orvostechnikai eszközként terjedt el az elmúlt kb. 10 évben a sebkezelés ún.…”

Section: T S Eliot: Négy Kvartett/1unclassified

Balassa Emlékelőadás 2019 – Sebészet és innováció

Harsányi

2020

MaSeb

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“…Az első ilyen műtét 2012-ben történt a klinikán és először hazánkban. 10 A rendkívül magas reszekciós arány ellenére a szövődmények lehetősége miatt az eljárás csak szoros feltételek mellett történő betegszelekció után végezhető. Az eljárás kidolgozásában, a szövődmény arányának csökkentésében, a műtéti technika módosításában klinikánk világviszonylatban is vezető szerepet játszik [11][12][13] Ennek standard eljárása a 70-es évek elejére alakult ki: 2 × 30 perc, közte 2-3 perces szünet "fl ush" perfúzióval.…”

Section: A Modern Korunclassified