2010
DOI: 10.1016/j.virusres.2010.07.027
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Alphavirus vectors for cancer therapy

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Cited by 59 publications
(54 citation statements)
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“…Semliki Forest virus (SFV)-based RNA viral vectors have been developed for vaccination and immunotherapy of cancer (1,2). These propagation-deficient vectors can accommodate expression cassettes and have been engineered to encode cytokines and other proimmunogenic transgenes.…”
Section: Introductionmentioning
confidence: 99%
“…Semliki Forest virus (SFV)-based RNA viral vectors have been developed for vaccination and immunotherapy of cancer (1,2). These propagation-deficient vectors can accommodate expression cassettes and have been engineered to encode cytokines and other proimmunogenic transgenes.…”
Section: Introductionmentioning
confidence: 99%
“…Several viral vectors, such as adenovirus, retrovirus, or alphavirus, have been used to deliver IL12 to the tumor site in different animal tumor models (14)(15)(16). Replication-defective alphavirus vectors based on Semliki Forest virus (SFV) have shown several advantages over adenoviral vectors in preclinical studies of cancer treatment, such as higher expression levels, and induction of immunogenic apoptosis in the infected tumor cells, in which abundant viral RNA co-opts all the protein translation machinery (17,18).…”
Section: Introductionmentioning
confidence: 99%
“…SFV vectors are based on a viral-positive single stranded (ss)RNA genome, in which the region coding for the structural proteins has been replaced by the transgene (19). SFV vectors expressing IL12 (SFV-IL12) have been shown to be very efficient in inducing therapeutic antitumor responses mediated by antitumor cytotoxic T lymphocytes in tumor models of colon adenocarcinoma, sarcoma, and glioma in mice (16), orthotopic hepatocellular carcinoma in rats (18), and spontaneous hepatocellular carcinoma in woodchucks (20).…”
Section: Introductionmentioning
confidence: 99%
“…These SFV replicons could be packaged into viral particles by providing helper RNAs expressing SFV capsid and envelope proteins in trans [36], or by expressing these proteins from inducible promoters in the same cells. Since cytopathic alphavirus vectors have shown a great potential for vaccination and cancer gene therapy, the cell lines described in this work could also be attractive for this field [37].…”
Section: Discussionmentioning
confidence: 99%