Alphaherpesvirus-mediated remodeling of the cellular transcriptome results in depletion of m6A-containing transcripts

Jansens, Robert J. J.; Olarerin-George, Anthony O.; Verhamme, Ruth; Mirza, Aashiq H.; Jaffrey, Samie R.; Favoreel, Herman

doi:10.1016/j.isci.2023.107310

Cited by 3 publications

(1 citation statement)

References 89 publications

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“…Hesser and Walsh also observed that the infection time of HSV1 suppresses YTHDF proteins [ 112 ]. Jansens et al found that suppressing m 6 A-methylated HSV transcripts depended on the YTHDF reader protein family and correlated with the localization of these proteins to enlarged P-bodies [ 152 ]. Wang et al identified that METTL3 is aberrantly expressed in mouse corneal endothelial cells and human umbilical vein endothelial cells infected with HSV1.…”

Section: The Role Of the M 6 A Modifications In Th...mentioning

confidence: 99%

m6A Methylation in Regulation of Antiviral Innate Immunity

Karandashov,

Kachanov,

Dukich

et al. 2024

Viruses

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The epitranscriptomic modification m6A is a prevalent RNA modification that plays a crucial role in the regulation of various aspects of RNA metabolism. It has been found to be involved in a wide range of physiological processes and disease states. Of particular interest is the role of m6A machinery and modifications in viral infections, serving as an evolutionary marker for distinguishing between self and non-self entities. In this review article, we present a comprehensive overview of the epitranscriptomic modification m6A and its implications for the interplay between viruses and their host, focusing on immune responses and viral replication. We outline future research directions that highlight the role of m6A in viral nucleic acid recognition, initiation of antiviral immune responses, and modulation of antiviral signaling pathways. Additionally, we discuss the potential of m6A as a prognostic biomarker and a target for therapeutic interventions in viral infections.

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Section: The Role Of the M 6 A Modifications In Th...mentioning

confidence: 99%

m6A Methylation in Regulation of Antiviral Innate Immunity

Karandashov,

Kachanov,

Dukich

et al. 2024

Viruses

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The YTH domain‐containing protein family: Emerging players in immunomodulation and tumour immunotherapy targets

Li,

Zeng,

Liu

et al. 2024

Clinical & Translational Med

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BackgroundThe modification of N6‐methyladenosine (m6A) plays a pivotal role in tumor by altering both innate and adaptive immune systems through various pathways, including the regulation of messenger RNA. The YTH domain protein family, acting as “readers” of m6A modifications, affects RNA splicing, stability, and immunogenicity, thereby playing essential roles in immune regulation and antitumor immunity. Despite their significance, the impact of the YTH domain protein family on tumor initiation and progression, as well as their involvement in tumor immune regulation and therapy, remains underexplored and lacks comprehensive review.ConclusionThis review introduces the molecular characteristics of the YTH domain protein family and their physiological and pathological roles in biological behavior, emphasizing their mechanisms in regulating immune responses and antitumor immunity. Additionally, the review discusses the roles of the YTH domain protein family in immune‐related diseases and tumor resistance, highlighting that abnormal expression or dysfunction of YTH proteins is closely linked to tumor resistance.Key points This review provides an in‐depth understanding of the YTH domain protein family in immune regulation and antitumor immunity, suggesting new strategies and directions for immunotherapy of related diseases. These insights not only deepen our comprehension of m6A modifications and YTH protein functions but also pave the way for future research and clinical applications.

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m6A Methylation in Regulation of Antiviral Innate Immunity

Karandashov,

Kostyusheva,

Kachanov

et al. 2024

Preprint

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The epitranscriptomic modification m6A is a prevalent RNA modification that plays a crucial role in the regulation of various aspects of RNA metabolism. It has been found to be involved in a wide range of physiological processes and disease states. Of particular interest is the role of m6A machinery and modifications in viral infections, serving as an evolutionary marker for distinguishing between self and non-self entities. In this review article, we present a comprehensive overview of the epitranscriptomic modification m6A and its implications in the interplay between viruses and their host, focusing on immune responses and viral replication. We outline future research directions that highlight the role of m6A in viral nucleic acid recognition, initiation of antiviral immune responses, and modulation of antiviral signaling pathways. Additionally, we discuss the potential of m6A as a prognostic biomarker and a target for therapeutic interventions in viral infections.

show abstract

Alphaherpesvirus-mediated remodeling of the cellular transcriptome results in depletion of m6A-containing transcripts

Cited by 3 publications

References 89 publications

m6A Methylation in Regulation of Antiviral Innate Immunity

m6A Methylation in Regulation of Antiviral Innate Immunity

The YTH domain‐containing protein family: Emerging players in immunomodulation and tumour immunotherapy targets

m6A Methylation in Regulation of Antiviral Innate Immunity

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