Alphafetoprotein in Paediatrics

Bergstrand, C. G.

doi:10.1111/j.1651-2227.1986.tb10149.x

Cited by 29 publications

(15 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The HLA gene complex has been repeatedly studied for its association with DR for the past 30 years with both negative [29], [30], [31], [32], [33], [34], [35], [36] and positive findings [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49]. Two separate properties of the HLA complex make it difficult to study.…”

Section: Introductionmentioning

confidence: 99%

HLA Genes, Islet Autoantibodies and Residual C-Peptide at the Clinical Onset of Type 1 Diabetes Mellitus and the Risk of Retinopathy 15 Years Later

et al. 2011

View full text Add to dashboard Cite

Aims/HypothesisHLA genes, islet autoantibodies and residual C-peptide were studied to determine the independent association of each exposure with diabetic retinopathy (DR), 15 years after the clinical onset of type 1 diabetes in 15–34 year old individuals.MethodsThe cohort was identified in 1992 and 1993 by the Diabetes Incidence Study in Sweden (DISS), which investigates incident cases of diabetes for patients between 15 and 34 years of age. Blood samples at diagnosis were analyzed to determine HLA genotype, islet autoantibodies and serum C-peptide. In 2009, fundus photographs were obtained from patient records. Study measures were supplemented with data from the Swedish National Diabetes Registry.ResultsThe prevalence of DR was 60.2% (148/246). Autoantibodies against the 65 kD isoform of glutamate decarboxylase (GADA) at the onset of clinical diabetes increased the risk of DR 15 years later, relative risk 1.12 for each 100 WHO units/ml, [95% CI 1.02 to 1.23]. This equates to risk estimates of 1.27, [95% CI 1.04 to 1.62] and 1.43, [95% CI 1.06 to 1.94] for participants in the highest 25th (GADA>233 WHO units/ml) and 5th percentile (GADA>319 WHO units/ml) of GADA, respectively. These were adjusted for duration of diabetes, HbA1c, treated hypertension, sex, age at diagnosis, HLA and C-peptide. Islet cell autoantibodies, insulinoma-antigen 2 autoantibodies, residual C-peptide and the type 1 diabetes associated haplotypes DQ2, DQ8 and DQ6 were not associated with DR.ConclusionsIncreased levels of GADA at the onset of type 1 diabetes were associated with DR 15 years later. These results, if confirmed, could provide additional insights into the pathogenesis of the most common microvascular complication of diabetes and lead to better risk stratification for both patient screenings and DR treatment trials.

show abstract

Section: Introductionmentioning

confidence: 99%

HLA Genes, Islet Autoantibodies and Residual C-Peptide at the Clinical Onset of Type 1 Diabetes Mellitus and the Risk of Retinopathy 15 Years Later

et al. 2011

View full text Add to dashboard Cite

show abstract

“…This could be due to either an increased synthesis of a-FP in the liver or a delay in the repression mechanism of its synthesis. However, there is no reason for excessive a-FP synthesis since there is no clinical or postmortem evi dence of liver pathology in CH newborns, in contrast to what is described in other patho logical situations in which a-FP is increased (hereditary tyrosinemia [15], ataxia telan giectasia [16], liver cancer [17]). Therefore, it is postulated that a delay in the repression of its synthesis process could be responsible for this increase.…”

Section: Discussionmentioning

confidence: 75%

α-Fetoprotein in Congenital Hypothyroidism

Mengreli

Sarafidou²,

Petmezaki³

et al. 1990

Neonatology

View full text Add to dashboard Cite

α-Fetoprotein (α-FP) was measured in dried blood spots from normal, congenital hypothyroid (CH) and transient hyperthyrotropinemic (TH) newborns as well as in serum from CH and TH babies together with thyroxine, triiodothyronine and thyrotropin. The half-life of α-FP had a median value of 12 days in the CH cases and 4.9 days in the TH cases. α-FP was significantly higher in the CH group before treatment and showed a significant rise after discontinuation of thyroxine therapy. It would appear that thyroid hormones influence α-FP metabolism and that a hypothyroid environment results in increased α-FP levels.

show abstract

“…AFP is one of the major proteins in fetal serum and it can be detected at 4 weeks of gestational age, when it is synthesized by the yolk sac and, subsequently, it is produced in the fetal liver [1]. AFP rises in hepatoblastoma because it originates from a staminal hepatic cell able to produce this protein.…”

Section: Discussionmentioning

confidence: 99%

Hepatic hematoma in a neonate with a high level of alpha-fetoprotein

et al. 2007

View full text Add to dashboard Cite

Hepatic hematomas in neonates are uncommon lesions. When they are large or subcapsular in location, they can rupture with clinical signs of hemoperitoneum. We report a case of subcapsular hepatic hematoma (SHH) associated with a high level of alpha-fetoprotein (AFP), for which diagnosis was made with conservative management, following up with the reduction in size at ultrasound examination and the reduction of the level of AFP.

show abstract

Alphafetoprotein in Paediatrics

Cited by 29 publications

References 64 publications

HLA Genes, Islet Autoantibodies and Residual C-Peptide at the Clinical Onset of Type 1 Diabetes Mellitus and the Risk of Retinopathy 15 Years Later

HLA Genes, Islet Autoantibodies and Residual C-Peptide at the Clinical Onset of Type 1 Diabetes Mellitus and the Risk of Retinopathy 15 Years Later

α-Fetoprotein in Congenital Hypothyroidism

Hepatic hematoma in a neonate with a high level of alpha-fetoprotein

Contact Info

Product

Resources

About