Alphacoronavirus in urban Molossidae and Phyllostomidae bats, Brazil

Asano, Karen Miyuki; Hora, Aline Santana da; Scheffer, K. C.; Fahl, W. O.; Iamamoto, Keila; Mori, Ênio; Brandão, Paulo Eduardo

doi:10.1186/s12985-016-0569-4

Cited by 25 publications

(34 citation statements)

References 29 publications

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“…In general, phylogenetic analysis revealed an expected strain-host specificity independent of geographical distance, in line with previous findings for the targeted viral families [1,28,[56][57][58][62][63][64][65][66][67][68]. At a finer scale, clustering patterns of coronavirus strains for C. gouldii and C. morio, may reflect the ecological connectivity between host populations.…”

Section: Discussionsupporting

confidence: 89%

Viral Diversity of Microbats within the South West Botanical Province of Western Australia

Prada

Boyd

Baker

et al. 2019

Viruses

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Bats are known reservoirs of a wide variety of viruses that rarely result in overt clinical disease in the bat host. However, anthropogenic influences on the landscape and climate can change species assemblages and interactions, as well as undermine host-resilience. The cumulative result is a disturbance of bat-pathogen dynamics, which facilitate spillover events to sympatric species, and may threaten bat communities already facing synergistic stressors through ecological change. Therefore, characterisation of viral pathogens in bat communities provides important basal information to monitor and predict the emergence of diseases relevant to conservation and public health. This study used targeted molecular techniques, serological assays and next generation sequencing to characterise adenoviruses, coronaviruses and paramyxoviruses from 11 species of insectivorous bats within the South West Botanical Province of Western Australia. Phylogenetic analysis indicated complex ecological interactions including virus-host associations, cross-species infections, and multiple viral strains circulating concurrently within selected bat populations. Additionally, we describe the entire coding sequences for five alphacoronaviruses (representing four putative new species), and one novel adenovirus. Results indicate that viral burden (both prevalence and richness) is not homogeneous among species, with Chalinolobus gouldii identified as a key epidemiological element within the studied communities.

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Section: Discussionsupporting

confidence: 89%

Viral Diversity of Microbats within the South West Botanical Province of Western Australia

Prada

Boyd

Baker

et al. 2019

Viruses

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“…A prevalence of 17.2% was observed among bats sampled from the São José do Rio Preto region which is similar to the rate of 16.7% reported in bats from Hong Kong [47]. Although one study in the UK reported a comparably high BtCoV prevalence of 23% [48], reported prevalence rates usually range from 3% to 10% [13,16,17,22,24,[49][50][51][52][53], similar to our current findings in the Barreiras region (2.56%). A global study with over 12,000 samples reported a BtCoV prevalence of 8.6% [54].…”

Section: Discussionsupporting

confidence: 88%

“…Numerous viruses have been reported to infect bats, and these animals are being studied as potential reservoir for several zoonotic diseases, including Coronaviruses [3,9,10]. The majority of Bat Coronavirus (BtCoV) have been identified in bats from Asia, Africa, and Europe [11][12][13][14][15][16][17][18][19]; however, CoV has also been reported in bats from South American countries including Brazil, Trinidad, Costa Rica, Ecuador, Panama, and Mexico [20][21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Alphacoronavirus Detection in Lungs, Liver, and Intestines of Bats from Brazil

et al. 2019

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Bats are flying mammals distributed worldwide known to host several types of Coronavirus (CoV). Since they were reported as the probable source of spillover of highly pathogenic CoV into the human population, investigating the circulation of this virus in bats around the world became of great importance. We analyzed samples from 103 bats from two distinct regions in Brazil. Coronavirus from the Alphacoronavirus genus was detected in 12 animals, 11 from São José do Rio Preto-SP region and 1 from Barreiras-BA region, resulting in a prevalence of 17.18% and 2.56% respectively. The virus was detected not only in intestines but also in lungs and liver. Phylogenetic analysis based on nsP12 genomic region suggests that the sequences group according to host family and sampling location. Studies on the circulation of these viruses in bats remain important to understand the ecology and evolutionary relationship of these pathogens.

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“…In Brazil, adenoviruses, anelloviruses, circoviruses, coronaviruses, polyomaviruses, parvoviruses and rhabdoviruses have already been detected in different bat species [16,20,[27][28][29][30]. However, previous studies were performed using traditional genome amplification methods.…”

Section: Introductionmentioning

confidence: 99%

Detection of adenovirus, papillomavirus and parvovirus in Brazilian bats of the species Artibeus lituratus and Sturnira lilium

et al. 2019

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Bats play a significant role in maintaining their ecosystems through pollination, dispersal of seeds, and control of insect populations, but they are also known to host many microorganisms and have been described as natural reservoirs for viruses with zoonotic potential. The diversity of viruses in these animals remains largely unknown, however, because studies are limited by species, location, virus target, or sample type. Therefore, the aim of this study was to detect fragments of viral genomes in bat samples. We performed high-throughput sequencing analysis and specific PCR and RT-PCR on pools of anal and oropharyngeal swabs from Artibeus lituratus and Sturnira lilium collected in southern Brazil. As a result, a member of the family Adenoviridae related to human adenovirus C was detected in anal swabs from S. lilium. In addition, we detected a papillomavirus in an anal swab from A. lituratus. Our analyses also allowed the detection of adenoviruses and parvoviruses in oropharyngeal swabs collected from A. lituratus. These results increase our knowledge about viral diversity and illustrate the importance of conducting virus surveillance in bats.

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Alphacoronavirus in urban Molossidae and Phyllostomidae bats, Brazil

Cited by 25 publications

References 29 publications

Viral Diversity of Microbats within the South West Botanical Province of Western Australia

Viral Diversity of Microbats within the South West Botanical Province of Western Australia

Alphacoronavirus Detection in Lungs, Liver, and Intestines of Bats from Brazil

Detection of adenovirus, papillomavirus and parvovirus in Brazilian bats of the species Artibeus lituratus and Sturnira lilium

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