Alphacoronavirus Detected in Bats in the United Kingdom

August, Tom; Mathews, Fiona; Nunn, Miles A.

doi:10.1089/vbz.2011.0829

Cited by 38 publications

(50 citation statements)

References 14 publications

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“…In Cambodia, an association between host and virus clade was observed between bats from the genus Myotis and the αCoVs genetically related to PEDV strains. These results are in line with conclusions of previous studies: all CoVs detected in bats belonging to the Myotis genus were always αCoVs (Tang et al, 2006;Woo et al, 2006;Dominguez et al, 2007;Gloza-Rausch et al, 2008;Osborne et al, 2011;August et al, 2012;Kemenesi et al, 2014;Fischer et al, 2016). βCoVs from lineage D have frequently been found in frugivorous bat species from Madagascar, Kenya, Thailand, and Hong Kong Anindita et al, 2015;Razanajatovo et al, 2015;Wacharapluesadee et al, 2015;Xu et al, 2016).…”

Section: Discussionsupporting

confidence: 92%

Genetic diversity of coronaviruses in bats in Lao PDR and Cambodia

Lacroix

Duong

Hul

et al. 2017

Infection, Genetics and Evolution

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South-East Asia is a hot spot for emerging zoonotic diseases, and bats have been recognized as hosts for a large number of zoonotic viruses such as Severe Acute Respiratory Syndrome (SARS), responsible for acute respiratory syndrome outbreaks. Thus, it is important to expand our knowledge of the presence of viruses in bats which could represent a risk to humans. Coronaviruses (CoVs) have been reported in bat species from Thailand, China, Indonesia, Taiwan and the Philippines. However no such work was conducted in Cambodia or Lao PDR. Between 2010 and 2013, 1965 bats were therefore sampled at interfaces with human populations in these two countries. They were tested for the presence of coronavirus by consensus reverse transcription-PCR assay. A total of 93 samples (4.7%) from 17 genera of bats tested positive. Sequence analysis revealed the presence of potentially 37 and 56 coronavirus belonging to alpha-coronavirus (αCoV) and beta-CoV (βCoV), respectively. The βCoVs group is known to include some coronaviruses highly pathogenic to human, such as SARS-CoV and MERS-CoV. All coronavirus sequences generated from frugivorous bats (family Pteropodidae) (n=55) clustered with other bat βCoVs of lineage D, whereas one coronavirus from Pipistrellus coromandra fell in the lineage C of βCoVs which also includes the MERS-CoV. αCoVs were all detected in various genera of insectivorous bats and clustered with diverse bat αCoV sequences previously published. A closely related strain of PEDV, responsible for severe diarrhea in pigs (PEDV-CoV), was detected in 2 Myotis bats. We highlighted the presence and the high diversity of coronaviruses circulating in bats from Cambodia and Lao PDR. Three new bat genera and species were newly identified as host of coronaviruses, namely Macroglossus sp., Megaerops niphanae and Myotis horsfieldii.

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Section: Discussionsupporting

confidence: 92%

Genetic diversity of coronaviruses in bats in Lao PDR and Cambodia

Lacroix

Duong

Hul

et al. 2017

Infection, Genetics and Evolution

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“…A prevalence of 17.2% was observed among bats sampled from the São José do Rio Preto region which is similar to the rate of 16.7% reported in bats from Hong Kong [47]. Although one study in the UK reported a comparably high BtCoV prevalence of 23% [48], reported prevalence rates usually range from 3% to 10% [13,16,17,22,24,[49][50][51][52][53], similar to our current findings in the Barreiras region (2.56%). A global study with over 12,000 samples reported a BtCoV prevalence of 8.6% [54].…”

Section: Discussionsupporting

confidence: 88%

Alphacoronavirus Detection in Lungs, Liver, and Intestines of Bats from Brazil

et al. 2019

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Bats are flying mammals distributed worldwide known to host several types of Coronavirus (CoV). Since they were reported as the probable source of spillover of highly pathogenic CoV into the human population, investigating the circulation of this virus in bats around the world became of great importance. We analyzed samples from 103 bats from two distinct regions in Brazil. Coronavirus from the Alphacoronavirus genus was detected in 12 animals, 11 from São José do Rio Preto-SP region and 1 from Barreiras-BA region, resulting in a prevalence of 17.18% and 2.56% respectively. The virus was detected not only in intestines but also in lungs and liver. Phylogenetic analysis based on nsP12 genomic region suggests that the sequences group according to host family and sampling location. Studies on the circulation of these viruses in bats remain important to understand the ecology and evolutionary relationship of these pathogens.

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“…Our results support previous findings about the high heterogeneity of CoVs hosted by bats and support the idea that novel species may be found in the future with increasing surveillance. Several studies described the presence of Alpha-CoV and Beta-CoVs in bats worldwide (Falcon et al, 2011;Gouilh et al, 2011;August et al, 2012;Goffard et al, 2015;Asano et al, 2016;Fischer et al, 2016;Goes et al, 2016;Subudhi et al, 2017;Ar Gouilh et al, 2018;Geldenhuys et al, 2018). However, most of these studies reported phylogenetic analysis on short sequences within the RdRp region, establishing the correlation with other CoV strains but not the assignment to CoV species as established by ICTV.…”

Section: Discussionmentioning

confidence: 99%

“…In Europe, several studies described the presence of CoVs in bat populations detecting both Alpha-CoVs and Beta-CoVs in Germany, Spain, Luxembourg, Italy, The Netherlands, the United Kingdom, France and Hungary (Gloza-Rausch et al, 2008;Reusken et al, 2010;Falcon et al, 2011;August et al, 2012;Lelli et al, 2013;Kemenesi et al, 2014;Goffard et al, 2015;Monchatre-Leroy et al, 2017;Pauly et al, 2017) from more than 20 different bat species. The detection of the same CoV strains (100% nucleotide identity) in different colonies of the same bat species or the circulation of different genera of CoVs (Alpha-CoVs and Beta-CoVs) in the same bat species confirm the high heterogeneity of CoVs in bats and that bat-CoV diversity depends more on the species-specificity than the geography and sampling location.…”

Section: Introductionmentioning

confidence: 99%

Full genome characterization of two novel Alpha-coronavirus species from Italian bats

et al. 2019

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A B S T R A C TCoronaviruses (CoVs) have been detected worldwide in several bat species, which are considered the main reservoir. The attention to the high diversity of CoVs hosted by bats has increased during the last decade due to the high number of human infections caused by two zoonotic Beta-CoVs, SARS-CoV and MERS-CoV, that cause several respiratory diseases. Among coronaviruses, two Alpha-CoV strains (HuCoV-229E and HuCoV-NL63) cause mild respiratory disease that can change to severe disease in children, elderly and individuals affected by illnesses. Phylogenetic analysis conducted on bat Alpha-CoV strains revealed their evolutive correlation to human strains, suggesting their origin in bats. The genome of CoVs is characterized by a high frequency of mutations and recombination events, increasing their ability to switch hosts and their zoonotic potential. In this study, three strains of Alpha-CoV genera detected in Italian bats (Pipistrellus kuhlii) were fully sequenced by Next Generation Sequencing (NGS) and characterized. The complete genome analysis showed the correlation of the Italians strains with a Chinese strain detected in 2013 and, based on CoV molecular species demarcation, two new Alpha-CoV species were established. The analysis of a fragment of the RNA-dependent RNA polymerase (RdRp) showed the correlation of the Italian strains with CoVs that was only detected in the bat Pipistrellus genera (Pipistrellus kuhlii and Pipistrellus Pipistrellus) in European countries.

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Alphacoronavirus Detected in Bats in the United Kingdom

Cited by 38 publications

References 14 publications

Genetic diversity of coronaviruses in bats in Lao PDR and Cambodia

Genetic diversity of coronaviruses in bats in Lao PDR and Cambodia

Alphacoronavirus Detection in Lungs, Liver, and Intestines of Bats from Brazil

Full genome characterization of two novel Alpha-coronavirus species from Italian bats

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