Alpha1-antitrypsin deficiency: An updated review

Mornex, Jean‐François; Traclet, Julie; Guillaud, Olivier; Dechomet, Magali; Lombard, Christine; Ruiz, Mathias; Revel, D.; Reix, Philippe; Cottin, Vincent

doi:10.1016/j.lpm.2023.104170

Cited by 2 publications

(1 citation statement)

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“…Alpha-1 antitrypsin deficiency models Alpha-1 antitrypsin (AAT) deficiency is a condition characterized by a lack of AAT due to mutations in the SERPINA1 gene [81,82]. More than 90% of severe deficiency patients are homozygous for Z (Glu342Lys) mutation.…”

Section: Monogenic Liver Disease Modelsmentioning

confidence: 99%

Research progress and application of liver organoids for disease modeling and regenerative therapy

Hu,

Geng,

Wang

et al. 2024

J Mol Med

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The liver is a major metabolic organ of the human body and has a high incidence of diseases. In recent years, the annual incidence of liver disease has increased, seriously endangering human life and health. The study of the occurrence and development mechanism of liver diseases, discovery of new therapeutic targets, and establishment of new methods of medical treatment are major issues related to the national economy and people’s livelihood. The development of stable and effective research models is expected to provide new insights into the pathogenesis of liver diseases and the search for more effective treatment options. Organoid technology is a new in vitro culture system, and organoids constructed by human cells can simulate the morphological structure, gene expression, and glucose and lipid metabolism of organs in vivo, providing a new model for related research on liver diseases. This paper reviews the latest research progress on liver organoids from the establishment of cell sources and application of liver organoids and discusses their application potential in the field of liver disease research.

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Section: Monogenic Liver Disease Modelsmentioning

confidence: 99%