Alpha1-adrenergic stimulation of ACTH secretion in vivo in the rat

Proulx-Ferland, Louise; Breault, Michel; Côté, James E.

doi:10.1016/s0278-5846(82)80123-1

Cited by 7 publications

(5 citation statements)

References 17 publications

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“…Other authors, however, have found that ui-AdRs are in volved in ACTH secretion [2,43], and, as shown in this study, about 30% of the ACTH-containing cells did not exhibit |i-AdR-like immunoreactivity. It is therefore likely that these cells contain txt-AdRs.…”

Section: Discussioncontrasting

confidence: 57%

“…Our own mor phological investigation demonstrated that P-AdR was present in ACTH-positive cells, suggesting that catecholamines directly bind to corticotrophs. In addition, several previous pharmaco logical studies have shown that p2-AdRs exist predominantly in the anterior pituitary, whereas |3|-AdRs do not [16, 41,42], and that a 2-AdRs are not involved in ACTH secretion [2,43], Thus, it may be concluded that the immunoreactive endproducts found in the ACTH-positive cells are the result of J^-AdR-like immunoreaction, though the possibility of cross-reaction with « 2-or Pi-AdRs cannot be totally excluded.…”

Section: Discussionmentioning

confidence: 99%

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Immunohistochemical Evidence That Most Rat Corticotrophs Contain Beta-Adrenergic Receptors

et al. 1989

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Cells bearing β-adrenergic receptors (β-AdRs) were found in the anterior lobe of the rat pituitary gland using anti-serum generated against affinity-purified β₂-AdRs, which also cross-reacts with βi-AdRs. β-AdR-positive cells were sparsely distributed in the anterior pituitary gland. The ultrastructure of these cells was similar to that of corticotrophs. Subsequent analysis of adjacent serial sections indicated that 75% of the ACTH-positive cells were β-AdR-positive. Our findings demonstrate the presence of β-AdRs on pituitary corticotrophs, which provides an anatomical basis for the direct regulation of corticotroph secretions by β-adrenergic agents.

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Section: Discussioncontrasting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Evidence That Most Rat Corticotrophs Contain Beta-Adrenergic Receptors

et al. 1989

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“…Experiment 2 Phentolamine, an antagonist that is equipotent at -I and a-2 adrenoceptors, increased adrenocortical activity under basal conditions in the rat, and this was interpreted as demonstrating a tonic inhibitory nor¬ adrenergic influence on the hypothalamo-pituitary adrenal axis (Scapagnini & Preziosi, 1973). However, more recent investigations have shown that the selec¬ tive -I adrenoceptor antagonist prazosin has no stimulant action on ACTH secretion in the rat (Proulx-Ferland, Breault & Cote, 1982;Szafarczyk, Malaval, Laurent et al 1987). Because of its a-2 antagonist activity, phentolamine increases nor¬ adrenaline turnover, which may result in increased ACTH secretion (see below).…”

Section: Central Catecholaminesmentioning

confidence: 99%

Adrenergic mechanisms in the control of corticotrophin secretion

Al-Damluji

1988

Journal of Endocrinology

126

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Although the data on the effects of adrenergic mechanisms on the secretion of ACTH had seemed confusing, most of the discrepancies are probably explicable on the basis of methodological differences. In the present state of knowledge, the following conclusions seem reasonable. (1) In both man and rat, activation of central alpha-1 adrenoceptors is followed by increased ACTH secretion and this mechanism is important in the control of secretion of this hormone under some physiological circumstances. (2) In man, peripheral circulating catecholamines do not stimulate ACTH secretion under physiological conditions. This conclusion probably also applies to the anterior pituitary corticotrophs of the rat. (3) In the rat, beta-2 adrenoceptor agonists stimulate the intermediate lobe by a direct action that is physiologically relevant. (4) The role of central beta and alpha-2 adrenoceptors requires further investigation.

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“…Much later, adrenalin was shown to stimulate corticosterone secretion in hypophysectomized rats (Inaba & Kamata 1975) and Walker et al (1988) showed that in vitro adrenalin stimulates cortisol secretion from adrenocortical cells. It was also shown that IV adrenalin increased ACTH secretion in conscious (Proulx-Ferland et al 1982) and anaesthetized rats (Tilders et al 1982), and that adrenalin stimulates corticotrophs in vitro (Labrie et al 1984). With advanced techniques that were not available in 1951, adrenalin has been revealed to act on both the anterior pituitary and the adrenal cortex to increase corticoid secretion; evidently, the uncertain conclusion about site of action in the 1951 paper (14) was correct.…”

Section: Adrenal Medulla Control Over Adrenal Cortex: a Possible Mechmentioning

confidence: 99%

Lillian Mary Pickford. 14 August 1902—14 August 2002

Morrison

Russell

2019

Biogr. Mems Fell. R. Soc.

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Mary Pickford was an experimental physiologist who carried out pioneering work on the actions of the hormones (oxytocin and vasopressin [ syn. antidiuretic hormone, ADH]) secreted by the posterior pituitary gland, which is part of the brain. She provided understanding of how the secretion of these hormones is controlled to regulate body fluid composition, specifically the maintenance, through actions on the kidneys, of normal osmolarity and Na + concentration, and hence blood volume and pressure. Using the water-loaded dog model she showed that vasopressin is the only hormone that regulates the excretion of water, by stimulating the kidneys to concentrate urine; she found that oxytocin could stimulate excretion of Na + . She showed that acetylcholine is an excitatory neurotransmitter in the hypothalamus, stimulating the neurons that produce vasopressin to secrete—the first evidence for acetylcholine action in the brain. The principles that Mary established have been extensively confirmed; hence, she was important in the establishment of the concepts and discipline of neuroendocrinology, which is about the bidirectional interactions between hormones and the brain. Using human and animal models, in her later work Mary focused on possible roles of interactions between female sex hormones and vasodilating actions of oxytocin in the perimenopausal problem of ‘hot flashes’ (or ‘hot flushes’) experienced by many women. She faced, but overcame, entrenched gender prejudice during her career; she was the first woman to be elected to the Pharmacological Society, and the first woman appointed to a chair in the Edinburgh Medical School.

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Alpha1-adrenergic stimulation of ACTH secretion in vivo in the rat

Cited by 7 publications

References 17 publications

Immunohistochemical Evidence That Most Rat Corticotrophs Contain Beta-Adrenergic Receptors

Immunohistochemical Evidence That Most Rat Corticotrophs Contain Beta-Adrenergic Receptors

Adrenergic mechanisms in the control of corticotrophin secretion

Lillian Mary Pickford. 14 August 1902—14 August 2002

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