(+)-.ALPHA.-Viniferin, an anti-inflammatory compound from Caragana chamlagu root.

Kitanaka, Susumu; Ikezawa, T.; Yasukawa, K.; Yamanouchi, Sakae; Takido, Michio; Sung, Hwan Kil; Kim, Il Hyuk

doi:10.1248/cpb.38.432

Cited by 81 publications

(45 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1A) is an oligostilbene of trimeric resveratrol and was firstly isolated as the anti-inflammatory constituent of Caragana chamlagu (21), an herbal medicine used for anti-arthritic purpose in Korea. We also isolated α-viniferin as an inhibitor of prostagladin H 2 synthase from another plant, Carex humilis (22), and demonstrated its anti-inflammatory efficacy on carrageenin-induced paw edema in mice (23).…”

Section: Introductionmentioning

confidence: 99%

α-Viniferin Suppresses the Signal Transducer and Activation of Transcription-1 (STAT-1)–Inducible Inflammatory Genes in Interferon-γ–Stimulated Macrophages

et al. 2010

View full text Add to dashboard Cite

Abstract. α-Viniferin, an oligostilbene of trimeric resveratrol, has been reported to have antiinflammatory potential in carrageenin-induced paw edema or adjuvant-induced arthritis in animal models. However, little is known about the molecular basis. In this study, α-viniferin at 3 -10 μM dose-dependently inhibited interferon (IFN)-γ-induced Ser 727 phosphorylation of the signal transducer and activation of transcription-1 (STAT-1), a pivotal transcription factor controlling IFN-γ-targeted genes, in RAW 264.7 macrophages, and also IFN-γ-induced activation of the extracellular signal-regulated kinase (ERK)-1, a protein kinase upstream of the Ser 727 phosphorylation of STAT-1. However, α-viniferin, only at a higher concentration of 10 μM, inhibited Janus kinase 2-mediated Tyr 701 phosphorylation of STAT-1 in the cells. To understand STAT-1-dependent inflammatory responses, we quantified nitric oxide (NO) or chemokines. α-Viniferin at 3 -10 μM dose-dependently inhibited IFN-γ-induced production of NO, IFN-γ-inducible protein-10 (IP-10), or the monokine induced by IFN-γ (MIG) in RAW 264.7 cells and also that of NO in primary macrophages-derived from C57BL/6 mice. Furthermore, α-viniferin diminished IFN-γ-induced protein levels of inducible NO synthase (iNOS), attenuated mRNA levels of iNOS, IP-10, or MIG as well as inhibited promoter activity of the iNOS gene. In conclusion, this study proposes an antiinflammatory mechanism of α-viniferin, down-regulating STAT-1-inducible inflammatory genes via inhibiting ERK-mediated STAT-1 activation in IFN-γ-stimulated macrophages.

show abstract

Section: Introductionmentioning

confidence: 99%

α-Viniferin Suppresses the Signal Transducer and Activation of Transcription-1 (STAT-1)–Inducible Inflammatory Genes in Interferon-γ–Stimulated Macrophages

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Lots of health benefits of grapevine such as chemopreventive, antimicrobial, antioxidant and anti-inflammatory activities [1][2][3][4] has been reported and resveratrol (3,5,4'-trihydroxystilbene), a reputed constituent of grapevine is regarded as an active principle of above mentioned biological activities. Grapevine is known as an important source of resveratrol and many naturally occurring hydroxystilbene components.…”

mentioning

confidence: 99%

“…Structures of the isolated active components (1)(2)(3)(4)(5)(6)(7)(8)(9)(10) were established by chemical and spectroscopic means. In the present paper, we describe the identification of a new glycoside of resveratrol dimer (1), together with the cytotoxic effect of ten resveratrol oligomers (1-10) isolated from the stem bark extract of grapevine (Fig.…”

mentioning

confidence: 99%

A New Glycoside of Resveratrol Dimer from Stem Bark of Vitis vinifera

Choi¹,

Choi²,

Cha³

et al. 2010

Bulletin of the Korean Chemical Society

View full text Add to dashboard Cite

“…In the same way as structure determination of balanocarpol, the compounds 2, 3, 4, and 5 are e-viniferin [24], a-viniferin [25], vaticanol B [26], and hopeaphenol [27], respectively. Refers to a previous study [20], three compounds were isolated from D. lanceolata from Kendari, namely, balanocarpol, e-viniferin, and a-viniferin, not reported from Malaysia's D. lanceolata.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial and Cytotoxic Potencies of Stilbene Oligomers From Stem Barks of Baoti (Dryobalanops Lanceolata) Growing in Kendari, Indonesia

Sahidin

Wahyuni²,

Malaka³

et al. 2017

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: The purpose of the research is to isolate and to identify compounds from stem barks of Dryobalanops lanceolata and to evaluate their activities toward bacteria and cancer cell lines. Methods:Isolation of the compounds worked with chromatography methods including thin-layer chromatography, vacuum liquid chromatography, and radial chromatography. All compound structures were determined based on the spectroscopic evidence including ultraviolet (UV), Infrared, and one-dimension and two-dimension nuclear magnetic resonance spectra and comparison the spectroscopy data with related data from references. The biological properties of compounds are evaluated toward bacteria Escherichia coli ATCC 35219 and Staphylococcus aureus ATCC 25923 and human breast cancer cell lines T-47D as cytotoxic potency.Results: Five stilbene oligomers have been isolated and identified from acetone extract of D. lanceolata stem barks namely balanocarpol (1), e-viniferin (2), a-viniferin (3), vaticanol B (4), and hopeaphenol (5). The inhibition zone value (in mm) of e-viniferin, balanocarpol, a-viniferin, hopeaphenol, and vaticanol B toward E. coli and S. aureus is 11±0.22 and 7±0.17, 9±0.17 and 13±0.12, 8±0.20 and 8±0.16, 6±0.16 and 8±0.11, and 5±0.12 and 4±0.14, respectively. Biological activity of the compounds against breast cancer cell lines T-47D (inhibitory concentration 50% in µM) for e-viniferin, balanocarpol, a-viniferin, hopeaphenol, and vaticanol B is 34.13±0.15, 98.17±0.41, 84.79±0.24, 52.04±0.26, and 119.30±0.54, respectively.Conclusions: e-viniferin is the most active compound toward E. coli and human breast cancer cell lines T-47D. Biological activity against bacteria S. aureus indicated that balanocarpol is the most potential compound.

show abstract

(+)-.ALPHA.-Viniferin, an anti-inflammatory compound from Caragana chamlagu root.

Cited by 81 publications

References 0 publications

α-Viniferin Suppresses the Signal Transducer and Activation of Transcription-1 (STAT-1)–Inducible Inflammatory Genes in Interferon-γ–Stimulated Macrophages

α-Viniferin Suppresses the Signal Transducer and Activation of Transcription-1 (STAT-1)–Inducible Inflammatory Genes in Interferon-γ–Stimulated Macrophages

A New Glycoside of Resveratrol Dimer from Stem Bark of Vitis vinifera

Antibacterial and Cytotoxic Potencies of Stilbene Oligomers From Stem Barks of Baoti (Dryobalanops Lanceolata) Growing in Kendari, Indonesia

Contact Info

Product

Resources

About