Alpha-tocopherol in plasma, red blood cells and lenses with and without cataract

Krepler, Katharina; Schmid, Rainer

doi:10.1016/j.ajo.2004.09.031

Cited by 15 publications

(5 citation statements)

References 27 publications

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“…Moreover, vitamin E supplements containing only α-tocopherol may also reduce other natural forms of vitamin E (46). Studies have shown 2-fold higher vitamin E concentrations in cataract lenses compared with noncataract lenses (47), and high plasma vitamin E concentrations have been associated with increased risk of all types of cataracts, but this was not observed for vitamin C (48).…”

Section: Discussionmentioning

confidence: 94%

High-Dose Supplements of Vitamins C and E, Low-Dose Multivitamins, and the Risk of Age-related Cataract: A Population-based Prospective Cohort Study of Men

Selin¹,

Rautiainen²,

Lindblad³

et al. 2013

American Journal of Epidemiology

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We examined the associations of high-dose supplements of vitamins C and E and low-dose multivitamins with the risk of age-related cataract among 31,120 Swedish men, aged 45-79 years, in a population-based prospective cohort. Dietary supplement use was assessed from a questionnaire at baseline in 1998. During follow-up (January 1998-December 2006), 2,963 incident age-related cataract cases were identified. The multivariable-adjusted hazard ratio for men using vitamin C supplements only was 1.21 (95% confidence interval (CI): 1.04, 1.41) in a comparison with that of non-supplement users. The hazard ratio for long-term vitamin C users (≥10 years before baseline) was 1.36 (95% CI: 1.02, 1.81). The risk of cataract with vitamin C use was stronger among older men (>65 years) (hazard ratio = 1.92, 95% CI: 1.41, 2.60) and corticosteroid users (hazard ratio = 2.11, 95% CI: 1.48, 3.02). The hazard ratio for vitamin E use only was 1.59 (95% CI: 1.12, 2.26). Use of multivitamins only or multiple supplements in addition to vitamin C or E was not associated with cataract risk. These results suggest that the use of high-dose (but not low-dose) single vitamin C or E supplements may increase the risk of age-related cataract. The risk may be even higher among older men, corticosteroid users, and long-term users.

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Section: Discussionmentioning

confidence: 94%

High-Dose Supplements of Vitamins C and E, Low-Dose Multivitamins, and the Risk of Age-related Cataract: A Population-based Prospective Cohort Study of Men

Selin¹,

Rautiainen²,

Lindblad³

et al. 2013

American Journal of Epidemiology

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“…No differences were found between erythrocyte antioxidant enzymes from animals with and without cataracts, but MDA plasma levels are increased and ascorbic acid concentrations decreased from animals with cataracts [49]. Others antioxidants present in lens, like lutein-zeaxanthin, retinoid, and tocopherol contents, do not show differences in concentration between normal and cataractous lenses [37], also, one study shows that concentration of α -tocopherol was significantly higher in cataract lenses than clear lenses [55]. …”

Section: Oxidative Stress and Globementioning

confidence: 99%

Antioxidants and the Integrity of Ocular Tissues

Cabrera

Chihuailaf

2011

Veterinary Medicine International

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Oxygen-derived free radicals are normally generated in many pathways. These radicals can interact with various cellular components and induce cell injury. When free radicals exceed the antioxidant capacity, cell injury causes diverse pathologic changes in the organs. The imbalance between the generation of free radicals and antioxidant defence is known as oxidative stress. The eye can suffer the effect of oxidative damage due to the etiopathogenesis of some pathological changes related to oxidative stress. This paper reviews the role of oxidative stress in the onset and progression of damage in different eye structures, the involvement of the antioxidant network in protecting and maintaining the homeostasis of this organ, and the potential assessment methodologies used in research and in some cases in clinical practice.

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“…The exchange of molecules between the aqueous humour and the lens [115] provides another potential mechanism by which the lens could clear some IR-induced oxysterols. Dietary anti-oxidants such as α-tocopherol, ascorbic acid and vitamin A as well as the endogenous lenticular glutathione [ 53 , [116] , [117] , [118] ] are all potential chemical antioxidants in the eye lens. Why then should the lens cortex be more sensitive to IR than the nucleus ( Fig.…”

Section: Discussionmentioning

confidence: 99%

Identification and quantification of ionising radiation-induced oxysterol formation in membranes of lens fibre cells

Uwineza¹,

Cummins²,

Jarrı́n³

et al. 2023

Advances in Redox Research

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Alpha-tocopherol in plasma, red blood cells and lenses with and without cataract

Cited by 15 publications

References 27 publications

High-Dose Supplements of Vitamins C and E, Low-Dose Multivitamins, and the Risk of Age-related Cataract: A Population-based Prospective Cohort Study of Men

High-Dose Supplements of Vitamins C and E, Low-Dose Multivitamins, and the Risk of Age-related Cataract: A Population-based Prospective Cohort Study of Men

Antioxidants and the Integrity of Ocular Tissues

Identification and quantification of ionising radiation-induced oxysterol formation in membranes of lens fibre cells

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