Alpha‐tocopherol and ginger are protective on Cyclophosphamide‐induced gonadal toxicity in adult male albino rats

Sabik, Laila M. E.; El-Rahman, Sahar S. Abd

doi:10.1111/j.1755-9294.2009.01034.x

Cited by 15 publications

(12 citation statements)

References 34 publications

(73 reference statements)

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“…The number of viable sperm was also significantly reduced in the CP treated group compared to the control group. This finding is in line with previous studies that indicate CP decreases sperm motility and viability in rats ( 46 , 51 ). Additionally, an increment in number of motile and live sperm was seen in CP groups supplemented with AM especially at doses 300 mg kg −1 /day and 500 mg kg −1 /day compared to the CP only treated group.…”

Section: Discussionsupporting

confidence: 93%

Ameliorative Effects of Aquilaria malaccensis Leaves Aqueous Extract on Reproductive Toxicity Induced by Cyclophosphamide in Male Rats

Razak

Ismail

Isa

et al. 2019

MJMS

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BackgroundCyclophosphamide (CP) is a widely used anti-neoplastic and immunosuppressive agent that is associated with adverse side effects including reproductive toxicity. Aquilaria malaccensis (AM) is a traditional medicinal plant which was reported to exhibit high anti-oxidant and free radical scavenging properties. The present study was aimed to evaluate the protective effects of AM leaves extract on sperm quality following toxic exposure to CP.MethodsForty-eight male Sprague Dawley rats were allocated into eight groups of six rats (n = 6): control, CP only (200 mg kg−1), AM only (100 mg kg−1, 300 mg kg−1 and 500 mg kg−1) and CP + AM (100 mg kg−1, 300 mg kg−1 and 500 mg kg−1). Animals were sacrificed after 63 days of treatment and the sperm from the caudal epididymis was taken for sperm analysis.ResultsThe body and the reproductive organs weight, sperm count and motility did not differ between CP and other groups (P > 0.05). A significant increase (P < 0.05) in percentage of the dead and abnormal sperm were seen in the CP alone treated group compared to the control group. Co-administration of AM to the CP exposed rats significantly reduced the (P < 0.05) percentage of abnormal sperm as compared to the CP only group.ConclusionOverall, the present results represent the potential of AM to protect against CP induced reproductive toxicity.

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Section: Discussionsupporting

confidence: 93%

Ameliorative Effects of Aquilaria malaccensis Leaves Aqueous Extract on Reproductive Toxicity Induced by Cyclophosphamide in Male Rats

Razak

Ismail

Isa

et al. 2019

MJMS

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“…The beneficial effects of ginger on sperm parameters of diabetic rats have also been reported (Hafez, ). Moreover, it compensated the harmful effect of toxic substances including sodium arsenite, alloxan, cyclophosphamide, gentamicin, deltamethrin, aluminium chloride and busulphan on epididymal sperm parameters (Bordbar et al., ; Hafez, ; Morakinyo et al., ; Moselhy et al., ; Sabik & Abd El‐Rahman, ; Sakr & Al‐Amoudi, ; Zahedi et al., ).…”

Section: Resultsmentioning

confidence: 99%

An evidence-based approach to medicinal plants for the treatment of sperm abnormalities in traditional Persian medicine

et al. 2016

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Infertility is defined as inability of a sexually active couple to conceive after 1 year of regular intercourse without contraception. Male factors account for 20%-50% of cases of infertility. The aim of this study was to review medicinal plants that proposed to improve sperm abnormalities in traditional Persian medicine. For this purpose, PubMed, Scopus, GoogleScholar and Cochrane library were explored for medicinal plants used in traditional Persian medicine for sperm abnormalities to obtain studies giving any evidence for their efficacy and pharmacological mechanisms related to male infertility. Data were collected for the years 1966 to March 2015. For some of them, including Chlorophytum borivilianum, Crocus sativus, Nigella sativa, Sesamum indicum, Tribulus terrestris, Mucuna pruriens and Withania somnifera, more reliable evidence was found. The mechanisms involved in the beneficial effects of medicinal plants in sperm abnormalities are antioxidant, anti-inflammatory, anti-oedematous and venotonic activity as well as containing precursors for sperm production and increasing blood testosterone level. Various phytochemical categories including saponins, phytosterols, carotenoids, oxygenated volatile compounds, phenolic compounds and alkaloids seem to be responsible for these beneficial effects. Further studies are recommended for obtaining more conclusive results about the efficacy and safety of the mentioned medicinal plants.

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“…Tribestan (patented extract of ginger) increases libido, infertility and menopausal disorders (Imani and Ainehchi, 2014). Also, ginger increases estrogen, pregnenolone and testosterone levels and sexual potency in men (Sabik et al 2009). Despite researches have been done on effects of the ginger on male reproductive sys-tem, its role on sex hormones in blood and testicular levels is not fully elicited.…”

Section: Introductionmentioning

confidence: 99%

Effect of ginger, Zingiber officinale on sex hormones and certain biochemical parameters of male Wistar rats

Afzali¹,

Ghalehkandi²

2018

Biosci. Biotech. Res. Comm

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It is well demonstrated that phytoestrogens play an important role in the male reproductive system. So, the aim of the current study was to determine effect of ginger on sex hormones and blood biochemical levels in rat. A 40 male Wistar rats (200-250 g) kept as folk and fed basal chew pellet for a week, then randomly divided into 4 experimental groups. Group 1 was kept as control and fed basal diet (commercial chew pellet) and orally gavage with distilled water. Groups 2-4, provided basal diet and orally gavage of the 100, 200 and 300 mg ginger powder in distilled water, respectively for 4 weeks. At the end of the study, Serum glucose, cholesterol, triglyceride, LDL, HDL, albumin, total protein, urea as well as LH, FSH and testosterone determined. Then animals sacrifi ced and sperm was collected from epididymis and prepared for spermatozoa characteristics, semen testosterone, LH and FSH levels. According to the results, dose dependent increase observed on spermatozoa forward movement (P=0.0001). A dose dependent increase observed on sperm viability (P=0.0001). Orally administration of the 100, 200 and 300 mg of the ginger signifi cantly increased serum total protein (P=0.0008) and decreased glucose (P=0.014) compared to the control group. Administration of the ginger in a dose dependent manner increased serum triglyceride (P=0.01) and HDL (P=0.0006) levels in rat compared to the control group. Orally gavage of the ginger signifi cantly increased semen testosterone levels in comparison to the control group (P=0.009) while had no signifi cant effect on LH and FSH levels (P>0.05). No significant effect observed on serum LH, FSH and testosterone levels compared to the control group (P>0.05). These results suggested ginger improves spermatozoa characteristics and semen hormone level.

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Alpha‐tocopherol and ginger are protective on Cyclophosphamide‐induced gonadal toxicity in adult male albino rats

Cited by 15 publications

References 34 publications

Ameliorative Effects of Aquilaria malaccensis Leaves Aqueous Extract on Reproductive Toxicity Induced by Cyclophosphamide in Male Rats

Ameliorative Effects of Aquilaria malaccensis Leaves Aqueous Extract on Reproductive Toxicity Induced by Cyclophosphamide in Male Rats

An evidence-based approach to medicinal plants for the treatment of sperm abnormalities in traditional Persian medicine

Effect of ginger, Zingiber officinale on sex hormones and certain biochemical parameters of male Wistar rats

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