Alpha-terpineol grafted acetylated lentinan as an anti-bacterial adhesion agent

Universal Near-Infrared Fluorescent Nanoprobes for Detection and Real-Time Imaging of ATP in Real Food Samples, Living Cells, and Bacteria

“…Lentinan exhibits superior anti-cancer function based on inducing apoptosis of tumor cells, inhibiting the hyperplasia of tumor cells, or indirectly realizing anti-tumor activity through immune factors. − Importantly, the content of ATP usually maintains a stable linear relationship with living cells but it fluctuates significantly during apoptosis . Encouraged by the excellent imaging effect of nanoprobe CYA@ZIF-90 on intracellular ATP, a model of lentinan-induced apoptosis in cancer cells (HepG2 cells) was constructed to monitor the real-time ATP fluctuation during the apoptosis process of cancer cells in real-time, and QSG-7701 cells treated with lentinan were set as the control group.…”

pH-Responsive Targeted Epigallocatechin Gallate-Delivery Nanosystem for in Vivo Persistent Luminescence Imaging and Synergistic Therapy of Bacterial Infection

“…Compared with the other groups, the degree of inflammatory cell infiltration in the ZEI@GCS + Laser group was lower, and the number of new capillaries and hair follicles was higher. In addition, the serum levels of TNF-α and IL-1β in the ZEI@GCS + Laser group were lower than those in the other four groups did not substantially differ from those in healthy mice (Figures C and D), − indicating good recovery of the infected mice in the ZEI@GCS + Laser group. Immunohistochemical staining of CD31 and CK14 (Figure B) were similar in the ZEI@GCS + Laser and normal groups, and compared with PBS, PBS + Laser, ICG+ Laser, and ZEI@GCS groups, the positive areas were reduced, the production of capillaries and keratin was reduced, and the infected wound recovered better.…”

“…Infectious diseases due to bacterial invasion constitute a serious threat to human life and health. − The advent of antibiotics, such as penicillin, offered hope for patients with infectious diseases; however, their subsequent overuse has engendered resistance in bacteria, − thus rendering drug-resistant infections an even more serious global health problem. − The use of natural antibacterial compounds as antibiotic-free strategies has emerged as promising a method to eliminate bacteria and avoid problems regarding the overuse of and resistance to synthetic antibiotics. − Among them, recently, epigallocatechin-3-gallate (EGCG), the most abundant polyphenol compound in green tea, has attracted the extensive attention of researchers. EGCG has been widely studied in various fields owing to its numerous useful pharmacological properties, including bactericidal, − anti-inflammatory, − antioxidant, , antiaging, proangiogenic, and anticancer effects. , However, EGCG has certain disadvantages, such as low bioavailability and fast metabolism, which limit its applicability in vivo.…”