Alpha-Synuclein Modulates Stimulated Exocytosis and Binds to Mitochondria

Abstract

cellular loops and a-helical transmembrane domains. The transmembrane domain of C99 has been studied extensively with different lipid models, but studies of the full-length structure are limited. To this end, we constructed the full-length C99 structure using homology modelling technique and to understand the impact of individual lipids on the structure and function of full-length of C99, we employ molecular dynamics simulations to study C99-lipid interplay at atomistic resolution in multiple membrane compositions, ranging from simple toward highly realistic neuronal membranes. This study sheds light on how individual lipids in different membrane compositions may interact with the peptides, regulate their dynamics and hence, physiological function.