Alpha-Synuclein and the Immune Response in Parkinson’s Disease

Chaperome screening leads to identification of Grp94/Gp96 and FKBP4/52 as modulators of the α‐synuclein‐elicited immune response

“…Nevertheless, the question regarding which immunological profiles are protective and which lead to neurodegeneration along the course of disease has not been completely resolved (12,13). Importantly, a link has been established between aSyn and the abnormal immunologic process that accompanies the onset and progression of synucleinopathies, which includes alterations in the T-cell-mediated immunity in the brain and in the peripheral system (14)(15)(16). Not surprisingly, several attempts have been made to induce a protective immune response against PD and other misfolding/amyloid disorders, including immunization with aSyninmousemodelsofdisease (17)(18)(19)(20)(21)(22)(23).…”