“…Modulating the sorting of apical SNARE can regulate the rate of endocytosis of apical proteins, thereby affecting signal transduction and epithelial cell proliferation [ 16 , 17 ]. A study elucidated that mutations in α-SNAP could activate the AMP-activated protein kinase (AMPK) pathway in neural stem/progenitor cells, thereby diminishing cell proliferation activity [ 18 ]. Some studies have reported a correlation between α-SNAP expression and the activation of PI3K/Akt/mTORCl signaling.…”