Alpha-pinene exerts neuroprotective effects via anti-inflammatory and anti-apoptotic mechanisms in a rat model of focal cerebral ischemia-reperfusion

Khoshnazar, Mahdieh; Parvardeh, Siavash; Bigdeli, Mohammad Reza

doi:10.1016/j.jstrokecerebrovasdis.2020.104977

Cited by 52 publications

(35 citation statements)

References 28 publications

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“…Amino acids, peptides, and mono-, di-, and tricarboxylic acids and their derivatives are the most mentioned types of compounds in pods, as shown in Table S4, with some of these substances already widely used in industry, such as citric and fumaric acids. Moreover, specialized metabolites such as camphene and α-pinene, which were also identified in soy pods, presented anti-skeletal muscle atrophy and neuroprotective effects, respectively [140,141]. Quercetin, which is a widely known flavonoid, may be a potential anti-inflammatory treatment in patients with COVID-19, as described by Saeedi-Boroujeni and Mahmoudian-Sani [142].…”

Section: Podsmentioning

confidence: 97%

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Metabolomics as a Tool to Study Underused Soy Parts: In Search of Bioactive Compounds

Bragagnolo

Funari

Ibáñez

2021

Foods

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The valorization of agri-food by-products is essential from both economic and sustainability perspectives. The large quantity of such materials causes problems for the environment; however, they can also generate new valuable ingredients and products which promote beneficial effects on human health. It is estimated that soybean production, the major oilseed crop worldwide, will leave about 597 million metric tons of branches, leaves, pods, and roots on the ground post-harvesting in 2020/21. An alternative for the use of soy-related by-products arises from the several bioactive compounds found in this plant. Metabolomics studies have already identified isoflavonoids, saponins, and organic and fatty acids, among other metabolites, in all soy organs. The present review aims to show the application of metabolomics for identifying high-added-value compounds in underused parts of the soy plant, listing the main bioactive metabolites identified up to now, as well as the factors affecting their production.

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Section: Podsmentioning

confidence: 97%

“…tive effects, respectively [140,141]. Quercetin, which is a widely known flavonoid, may be a potential anti-inflammatory treatment in patients with COVID-19, as described by Saeedi-Boroujeni and Mahmoudian-Sani [142].…”

Section: Podsmentioning

confidence: 99%

Metabolomics as a Tool to Study Underused Soy Parts: In Search of Bioactive Compounds

Bragagnolo

Funari

Ibáñez

2021

Foods

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“…essential oil, namely α-pinene and camphor, have been reported. For example, α-pinene was able to attenuate neuro-inflammation in a rat model of focal cerebral ischemia-reperfusion by decreasing both the gene and protein expression of TNF-α and IL-1β ( Khoshnazar et al, 2020 ). Moreover, in mouse peritoneal macrophages, this compound showed anti-inflammatory potential by suppressing the mitogen-activated protein kinases (MAPKs) and the NF-κB pathways ( Kim et al, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Lavandula viridis L´Hér. Essential Oil Inhibits the Inflammatory Response in Macrophages Through Blockade of NF-KB Signaling Cascade

et al. 2022

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Lavandulaviridis L´Hér. is an endemic Iberian species with a high essential oil yield and a pleasant lemon scent. Despite these interesting features, this species remains unrecognized and poorly explored by the food and pharmaceutical industries. Nevertheless, it has been valued in traditional medicine being used against flu, circulatory problems and to relieve headaches. Since these disorders trigger inflammatory responses, it is relevant to determine the anti-inflammatory potential of L. viridis L´Hér. essential oil in an attempt to validate its traditional use and concomitantly to increment its industrial exploitation. Therefore, in the present study the chemical composition of this volatile extract as well as the effect on ROS production, inflammatory response and proteasome activity on LPS-stimulated macrophages were disclosed. Also, its safety profile on keratinocytes, hepatocytes and alveolar epithelial cells was depicted, envisioning a future human administration. The essential oil was characterized by high quantities of 1,8-cineole, camphor and α-pinene. From a pharmacological point of view, the essential oil showed a potent antioxidant effect and inhibited nitric oxide production through down-modulation of nuclear factor kappa B-dependent Nos2 transcription and consequently iNOS protein expression as well as a decrease in proteasomal activity. The anti-inflammatory activity was also evidenced by a strong inhibition of LPS-induced Il1b and Il6 transcriptions and downregulation of COX-2 levels. Overall, bioactive safe concentrations of L. viridis L´Hér. essential oil were disclosed, thus corroborating the traditional usage of this species and paving the way for the development of plant-based therapies.

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“…O eucaliptol apresenta diversas propriedades, como potencial para o tratamento de asma e atividade terapêutica (JUERGENS et al, 2017;SOUTO et al, 2016). O α-pineno também é um composto que exibe algumas propriedades interessantes, como anti-inflamatória apurada em testes em camundongos e também atividade neuroprotetoras (KIM et al, 2015;KHOSHNAZAR et al, 2020).…”

Section: Discussionunclassified

Influência Da Luz Na Composição Do Óleo Essencial De Eucalipto (Eucalyptus Urograndis) / Influence of Light on the Composition of Eucalyptus Essential Oil (Eucalyptus Urograndis)

Maronde

Venancio

Lopes

et al. 2020

BJD

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Eucalyptus urograndis is a species of eucalyptus widely cultivated in Brazil, its essential oil has biological properties such as bactericide and insecticide. However, essential oils are fragile if exposed to light and high temperatures. Due to the great availability of Eucalyptus urograndis, and its properties, this work aimed to extract, chemical characterize and verify the stability of the essential oil of Eucalyptus urograndis in light exposure. The oil was extracted by dragging water vapor, and characterized using two gas chromatographs, one with a flame ionization detector (CG-DIC) and one with a mass spectroscopy detector (CG-EM). The oil showed eight compounds, the major ones being eucalyptol and α-pinene. The oil was stored in the absence and presence of light and at room temperature. The two major compounds were monitored over 21 days, we observed that there is no evidence that the exposure factor or not to light is responsible for variations in the contents of the two major compounds in the oil.

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Alpha-pinene exerts neuroprotective effects via anti-inflammatory and anti-apoptotic mechanisms in a rat model of focal cerebral ischemia-reperfusion

Cited by 52 publications

References 28 publications

Metabolomics as a Tool to Study Underused Soy Parts: In Search of Bioactive Compounds

Metabolomics as a Tool to Study Underused Soy Parts: In Search of Bioactive Compounds

Lavandula viridis L´Hér. Essential Oil Inhibits the Inflammatory Response in Macrophages Through Blockade of NF-KB Signaling Cascade

Influência Da Luz Na Composição Do Óleo Essencial De Eucalipto (Eucalyptus Urograndis) / Influence of Light on the Composition of Eucalyptus Essential Oil (Eucalyptus Urograndis)

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