Alpha-Pinene Alleviates Motor Activity in Animal Model of Huntington’s Disease via Enhancing Antioxidant Capacity

Abstract

Huntington's disease is a progressive, neurodegenerative, and inherited disease. Antioxidants have been shown effective in slowing disease progression in animal models of HD and are under investigation in human clinical trials. α-Pinene, a polyphenolic compound of the terpene family, has been shown to exert antioxidant activity. Therefore, this study aimed to investigate the impact of α-pinene on animal model of HD.Thirty-two male Wistar rats received 3-Nitropropionic acid (3-NP) for induction of the disease model or treated with α-pinene + 3-NP in different groups. Motor skill, and biochemical evaluations to detect oxidant/antioxidant markers in rat cortex and striatum were performed in all groups. We found that αpinene signi cantly improved 3-NP-induced changes in the body weight, rotarod activity, time taken to cross the narrow beam, and locomotor activity. Biochemical analysis revealed that α-pinene signi cantly decreased the 3NP-induced elevation in oxidant markers, nitrite, and malondialdehyde in both cortex and striatum. In addition, α-pinene counteracted the 3NP-induced fall in antioxidant enzymes, including superoxide dismutase, catalase, and glutathione in the cortex and striatum.In conclusion, we found that α-pinene prevented the motor dysfunction induced by 3-NP in the animal model of Huntington's disease. Oxidants-antioxidant balance might be involved in the protective effect of α-pinene.

Europinidin Mitigates 3-NPA-Induced Huntington’s Disease Symptoms in Rats: A Comprehensive Analysis of Oxidative Stress, Mitochondrial Enzyme Complex Activity, Pro-Inflammatory Markers and Neurotransmitter Alterations

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α-Pinene, a Main Component of Pinus Essential Oils, Enhances the Expression of Insulin-Sensitive Glucose Transporter Type 4 in Murine Skeletal Muscle Cells

“…Based on these characteristics, the future possible use of α-pinene as a vehicle for administering anti-diabetic drugs may result in a more powerful and efficient strategy for managing diabetes. In addition, the employment of α-pinene can increase the production of antioxidant enzymes at the cellular level, enhancing overall antioxidant capabilities to better counteract the harmful effects of oxygen-free radicals on lipid peroxidation [21]. Ultimately, this means that α-pinene has the potential to mitigate the complications associated with elevated oxidative stress found in diabetic tissues [22].…”

Biological activity of the essential oil of Drimys winteri

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