Alpha-mangostin inhibits dengue virus production and pro-inflammatory cytokine/chemokine expression in dendritic cells

Yongpitakwattana, Petlada; Morchang, Atthapan; Panya, Aussara; Sawasdee, Nunghathai; Yenchitsomanus, Pa‐thai

doi:10.1007/s00705-021-05017-x

Cited by 13 publications

(12 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, our data indicates that α-MG maximally inhibits the viral RNA synthesis step, but it does not affect the early stage (virus binding and entry), and the inhibitory effect markedly decreases at the late stage (virion assembly and budding) of the DENV life cycle. A similar observation was reported from a study that investigated the antiviral activity of α-MG in dendritic cells 36 .…”

Section: Discussionsupporting

confidence: 86%

“…α-MG was shown to effectively reduce DENV infection and progeny virus production in many cell types. In addition to human hepatic HepG2 and Huh-7 cells 24 , antiviral activity of α-MG was confirmed in monocyte-derived dendritic cells (moDCs), peripheral blood mononuclear cells (PBMCs), and Vero CCL81 cells 36 – 38 . The IC50 at 24 h post-treatment in PBMCs was 5.47 μM 37 and the IC50 in HepG2 and Huh-7 cells were 12.63 and 5.67 μM, respectively 24 .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Alpha-mangostin inhibits viral replication and suppresses nuclear factor kappa B (NF-κB)-mediated inflammation in dengue virus infection

Tarasuk

Songprakhon

Chieochansin

et al. 2022

Sci Rep

Self Cite

View full text Add to dashboard Cite

Severe dengue virus (DENV) infection results from viral replication and dysregulated host immune response, which trigger massive cytokine production/cytokine storm. The result is severe vascular leakage, hemorrhagic diathesis, and organ dysfunction. Subsequent to previously proposing that an ideal drug for treatment of DENV infection should efficiently inhibit both virus production and cytokine storm, we discovered that α-mangostin (α-MG) from the pericarp of the mangosteen fruit could inhibit both DENV infection and cytokine/chemokine production. In this study, we investigated the molecular mechanisms underlying the antiviral and anti-inflammatory effects of α-MG. Time-of-drug-addition and time-of-drug-elimination studies suggested that α-MG inhibits the replication step of the DENV life cycle. α-MG inhibited polymerization activity of RNA-dependent RNA polymerase (RdRp) with IC50 values of 16.50 μM and significantly reduced viral RNA and protein syntheses, and virion production. Antiviral and cytokine/chemokine gene expression profiles of α-MG-treated DENV-2-infected cells were investigated by polymerase chain reaction array. α-MG suppressed the expression of 37 antiviral and cytokine/chemokine genes that relate to the NF-κB signaling pathway. Immunofluorescence and immunoblot analyses revealed that α-MG inhibits NF-κB nuclear translocation in DENV-2-infected cells in association with reduced RANTES, IP-10, TNF-α, and IL-6 production. These results suggest α-MG as a potential treatment for DENV infection.

show abstract

Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Alpha-mangostin inhibits viral replication and suppresses nuclear factor kappa B (NF-κB)-mediated inflammation in dengue virus infection

Tarasuk

Songprakhon

Chieochansin

et al. 2022

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…These findings point to the possibility of developing α-mangostin as a new anti-DENV medication. 31 Presently, the possibility of various medicinal plants for antivirus to fight against SARS-CoV-2 has been reported by many researchers globally. In Asia, the Chinese herbal medicine tested to encounter SARS-CoV-2 by several researchers using in silico, 32,33 The traditional Himalayan medicinal plants also had been tested against SARS-CoV-2 which reported by Natesh et al 34 Moreover, the Indian traditional medicine were also having a good antiviral potential towards the SARS-CoV-2 in silico analysis.…”

Section: Resultsmentioning

confidence: 99%

Bioactive Compounds from Mangosteen (Garcinia mangostana L.) as an Antiviral Agent via Dual Inhibitor Mechanism against SARSCoV- 2: An In Silico Approach

Ansori¹,

Kharisma²,

Parikesit³

et al. 2022

View full text Add to dashboard Cite

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus that causes COVID-19 which is responsible for respiratory illness infection in humans. The virus was first identified in China in 2019 and later spread to other countries worldwide. This study aims to identify the bioactive compounds from mangosteen (Garcinia mangostana L.) as an antiviral agent via dual inhibitor mechanisms against two SARS-CoV-2 proteases through the in silico approach. The three-dimensional structure of various bioactive compounds of mangosteen from the database was examined. Furthermore, all the target compounds were analyzed for drug, antiviral activity prediction, virtual screening, molecular interactions, and threedimensional structure visualization. It aimed to determine the potential of the bioactive compounds from mangosteen that can serve as antiviral agents to fight SARS-CoV-2. Results showed that the bioactive compounds from mangosteen have the prospective to provide antiviral agents that contradict the virus via dual inhibitory mechanisms. In summary, the binding of the various bioactive compounds from mangosteen results in low binding energy and is expected to have the ability to induce any activity of the target protein binding reaction. Therefore, it allows various bioactive compounds from mangosteen to act as dual inhibitory mechanisms for COVID-19 infection.

show abstract

“…Alpha-Mangostin ( Figure 7 ) is a xantone with antimicrobial properties that was reported to induce IFN-I production in a STING-dependent manner, binding to the STING CTD. Alpha-Mangostin has been shown to have antiviral properties and activity against DENV and HBV replication in cell-based assays, while in vivo studies have not yet been performed [ 126 , 127 , 128 , 129 , 130 ].…”

Section: Sting Agonists As Broad-spectrum Antiviralsmentioning

confidence: 99%

Unlocking STING as a Therapeutic Antiviral Strategy

Paulis

Tramontano

2023

IJMS

View full text Add to dashboard Cite

Invading pathogens have developed weapons that subvert physiological conditions to weaken the host and permit the spread of infection. Cells, on their side, have thus developed countermeasures to maintain cellular physiology and counteract pathogenesis. The cyclic GMP-AMP (cGAMP) synthase (cGAS) is a pattern recognition receptor that recognizes viral DNA present in the cytosol, activating the stimulator of interferon genes (STING) protein and leading to the production of type I interferons (IFN-I). Given its role in innate immunity activation, STING is considered an interesting and innovative target for the development of broad-spectrum antivirals. In this review, we discuss the function of STING; its modulation by the cellular stimuli; the molecular mechanisms developed by viruses, through which they escape this defense system; and the therapeutical strategies that have been developed to date to inhibit viral replication restoring STING functionality.

show abstract

Alpha-mangostin inhibits dengue virus production and pro-inflammatory cytokine/chemokine expression in dendritic cells

Cited by 13 publications

References 36 publications

Alpha-mangostin inhibits viral replication and suppresses nuclear factor kappa B (NF-κB)-mediated inflammation in dengue virus infection

Alpha-mangostin inhibits viral replication and suppresses nuclear factor kappa B (NF-κB)-mediated inflammation in dengue virus infection

Bioactive Compounds from Mangosteen (Garcinia mangostana L.) as an Antiviral Agent via Dual Inhibitor Mechanism against SARSCoV- 2: An In Silico Approach

Unlocking STING as a Therapeutic Antiviral Strategy

Contact Info

Product

Resources

About