Alpha lipoic acid inhibits oxidative stress and up-regulation of MMPS in human saphenous vein grafts

Kalkan, Tugce; Bintepe, C.; Yurekli, Ismail; Ersoy, Nevin; Bağrıyanık, Hüsnü Alper; Reel, Buket

doi:10.1016/j.atherosclerosis.2020.10.786

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“…In comparison to the Control and ALA groups, 5-FU treatment enhanced MMP-1, MMP-2, MMP-8, and TIMP-1 activation in sera and tissues in the Mucositis + ALA group. Several models of inflammation have been utilized to examine the effect of ALA on the expression levels of MMP-1, MMP-2, MMP-8, and TIMP [ 72 , 73 ]. ALA’s anti-inflammatory and antioxidant effects in inflammation models have revealed that the protective effect is produced by lowering MMP-1, MMP-2, and MMP-8 expression while enhancing TIMP-1 activity [ 74 , 75 ].…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Alpha-Lipoic Acid against 5-Fluorouracil-Induced Gastrointestinal Mucositis in Rats

et al. 2022

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Alpha-lipoic acid (ALA) is extensively utilized in multivitamin formulas and anti-aging products. The purpose of this study was to investigate the potential protective benefits of ALA on 5-fluorouracil (5-FU)-induced gastrointestinal mucositis in Wistar albino rats. Tissues from the stomach, small intestine, and large intestine were excised, and blood sera were obtained to identify biochemical indices such as TNF-α, IL-1β, MDA, GPx, SOD, MMP-1, -2, -8, and TIMP-1. A histopathological study was also performed. The results revealed mucositis-elevated TNF-, IL-1, MDA, MMP-1, -2, -8, and TIMP-1 levels in both tissues and sera, and these values dropped dramatically following ALA treatment. Reduced SOD and GPx activities in mucositis groups were reversed in ALA-treated groups. The damage produced by mucositis in the stomach and small intestine regressed in the ALA-treated group, according to histopathological evaluation. Consequently, the implementation of ALA supplementation in 5-FU therapy may act as a protective intervention for cancer patients with gastrointestinal mucositis. In light of the findings, ALA, a food-derived antioxidant with pleiotropic properties, may be an effective treatment for 5-FU-induced gastrointestinal mucositus, and prevent oxidative stress, inflammation, and tissue damage in cancer patients receiving 5-FU therapy.

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